Neuroscience

Apoptotic effects of aluminum on astrocytes studied

Published in Pain and Central Nervous System Week, April 25th, 2005

Aluminum causes apoptosis in primary cultured astrocytes.

"Aluminum salts or doses that are unlikely in the human system have been employed in toxicity studies, and much attention had been focused on the secondary target (neurons) of its toxicity rather than the primary target (astroglia)," say Japanese researchers.

"In order to address these issues, we have investigated the uptake and apoptotic effects of aluminum amino acid complex on primary cultured astrocytes because these are fundamental in understanding the mechanism of aluminum neurotoxicity. Aluminum solubilized by various amino acids was differentially internalized by astrocytes...

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Source: Pain and Central Nervous System Week (2005-04-25)

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