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Neurology Vaccine

Vaccine to protect neurons against toxicity of nerve agents developed

Published in Pain and Central Nervous System Week, October 17th, 2005

Researchers have developed a post-intoxication vaccine for protection of neurons against the toxicity of nerve agents.

"Nerve agents are highly toxic organophosphates (OPs) that can cause severe damage to the central and peripheral nervous systems. The central nervous system insult results in seizures and neuronal death. The glutamatergic system apparently contributes to the neuropathology. Using a model of OP intoxication causing death of retinal ganglion cells in the mouse eye, we show here that intoxication is exacerbated if the mice are devoid of mature T cells," researchers in Israel report.

"The retinal neurons could be protected from these...

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