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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . November 7th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Anesthesiology - Near infrared laser device can measure brain oxygen levels during surgery

Apoptosis - Mitochondrial impairment is induced in cortical neurons after oxygen and glucose deprivation

Drug Abuse - Texas researchers find alterations in brain's circuitry caused by cocaine

Neuroscience - Ependymomas in other CNS locations appear to arise from radial glia cells

Pain Management - Local anesthetics are effective for neuropathic pain

Addiction Medicine - Beta-carbolines block opiate withdrawal

Adverse Drug Reaction - Case study suggests hydroxyurea therapy may be implicated in neuroendocrine carcinoma

Adverse Drug Reaction - Imidazenil antagonizes sedative but not anticonvulsant diazepam activity

Alcohol Use -  Evodiae fructus extracts promote expression of anti-hangover enzymes

Alzheimer Disease - Amyloid beta proteins promote oxidative lipid membrane damage

Alzheimer Disease - Clinical development commences for AZD-103 for Alzheimer disease

Alzheimer Disease - Dementia research provides hope for the future

Alzheimer Disease - New alliance signed regarding genetic research program for Alzheimer disease

Alzheimer Disease - Study shows protein test improves early detection, diagnosis of Alzheimer disease

Alzheimer Disease - Widespread protein insolubility detected early in Alzheimer disease

Amyloid Fibrils - Association of beta2 -microglobulin amyloid fibrils is thermally controlled

Analgesia - Pain scores look similar in patients given different liver biopsy procedures

Analgesia - Rat/mouse hemokinin-1 may have a crucial role in pain modulation

Anesthesia - Tiny worms paving way for better anesthetics

Anesthetics - GABA and opioid peptide receptors are involved in sevoflurane-induced spinal cord antinociception

Angiology - Endothelin-1 and endothelin receptors are over-expressed in retinal degeneration

Antidepressants - Continuous paroxetine treatment reduces SERT ligand binding sites and protein expression

Antipsychotic Drugs - Atypical antipsychotics for dementia may result in increased risk of death

Apoptosis - Low-dose cisplatin protects neuroblastoma SH-SY5Y cells from paclitaxel-induced apoptosis

Arthritis - Calcitonin gene-related peptide and TRPV1 may contribute to osteoarthritis pain

Arthritis - U.S., E.U. regulatory submission made seeking approval of Humira in ankylosing spondylitis

Atherosclerosis - Review discusses the 5-lipoxygenase - atherosclerosis connection

Awards - Neuroscientist Antonio Damasio receives Prince of Asturias prize

Back Pain - Search engine offers public information on spinal surgeries and back pain

Basilar Artery Occlusion - Endovascular mechanical thrombus extraction may be superior to thrombolysis

Biomedical Engineering - CT and foreign-body giant cell values higher in 30% than in 10% BaSO4 /PMMA, sheep model shows

Biowarfare - Hapten that hydrolyzes nerve agent has been developed

Bone Formation - Sclerostin is an osteocytic product that inhibits bone formation

Brain Cancer - Cytokines maintain neovascular growth in gliomas subjected to hypoxia

Business & Finance - Judith Gwathmey selected for U.S. National Institutes of Health program

Calcific Tendinitis - Computer-assisted 3-D navigation improves extracorporeal shock wave efficacy

Cancer Coping - Illness-related problems and coping among persons with low-grade glioma examined

Cancer Pain - Pancreatic cancer pain managed by either of two invasive techniques

Cancer Therapy - Cisplatinum re-challenge overcame carboplatin hypersensitivity

Cancer Therapy - Curcumin abolishes aberrant enzyme expression in brain tumor cells

Cancer Therapy - Endocrine late effects occurred from multi-modality treatment of neuroblastoma

Cancer Therapy - European marketing authorization application withdrawn for Revaproxyn

Cancer Therapy - Pyrazoloacridine and carboplatin used in phase I/II trial for recurrent glioma

Cancer Therapy - Registry launched for head and neck cancer patients

Cardiology - Cardiac valve pathology may be risk factor for several types of CNS involvement

Cardiology - Three-year trials demonstrate carotid stent durability in preventing stroke

Cardiovascular Research - Fibromyalgia patients have enhanced CV sympathetic activity while recumbent

Cardiovascular Research - Nervous regulation of atrial vs. ventricular vessels is highly differentiated

Cardiovascular Research - QRS shortening in tetralogy of Fallot is related with better exercise performance

Carotid Artery Disease - Simulation provider introduces training product for carotid stenting

Carotid Artery Stenosis - Novel scoring system predicts prolonged hypotension after carotid stenting

Cerebral Palsy - Shank muscles have reduced EMG during gait, while hamstrings show enhanced activation

Cerebrospinal Fluid - Near infrared fluorescence can image cerebrospinal fluid space and movement

Clinical Trials - Next clinical trial of drug injected into inflamed arthritic joints initiated

Clinical Trials - Twenty-six year data support efficacy, safety of Copaxone in relapsing-remitting MS

Cochlear Implants - Targeted phoneme training may hasten adaptation to spectrally shifted speech

Collaborations - Alliance to focus on development of anti-rheumatic agent in Japan

Craniopharyngioma - Fronto-basal approach effective for tumors extending outside suprasellar cistern

Cytology - Lipophilic ion modulator DP-109 membrane insertion involves membrane potential interactions

Dementia - Selegiline, alone or with donepezil, reduces memory impairment in rats

Depression - Cigna: Direct costs of depression in the workplace are tip of the iceberg

Depression Therapy - Long-term antidepressant treatment alters lipid composition of brain plasma membranes

Diagnostics - Companies team up to provide hs-CRP test for clinical trial recruitment and screenings

Diagnostics - Doctors are advised to carefully assess causes of traumatic brain injury in children

Diagnostics - Magnetic resonance spectroscopy differentiates high and low grade brain tumors

Diagnostics - Major depression predicts higher mortality following stem cell transplantation

Diet & Nutrition - Model designed to evaluate policies that influence population fish consumption

Disease Associations - Myristoyltransferase expression elevated in epilepsy

Drug Delivery - Lipophilic counter-ions improve benzydamine membrane diffusion

Drug Development - Biotech company to focus on developing hepatitis C, arthritis, CF drugs

Drug Development - Multiple dose study initiated for AEOL 10150 in patients with amyotrophic lateral sclerosis

Drug Development - Novel potent and selective MMP-13 inhibitors synthesized

Drug Development - Petition submitted to U.S. FDA for more rigorous bioequivalence testing for generic Adderall XR

Drug Development - Three new sites added to Indaflex phase II trial for osteoarthritis of the knee

Drug Development - U.S. FDA grants clearance to initiate phase II trials for abuse-resistant, extended-release opioid

Dystonia - Dystonia affects up to a quarter million people in the United States

Endometriosis - Practitioners need more training to provide diagnosis and support for women with endometriosis

Environmental Health -  p,p'-DDE treatment appears to increase aromatase activity in ESC in culture

Facilities - TGen and St. Joseph's launch Pediatric Neurogenetics Center

Finance - Drug development company reports placement of $40 million of convertible notes

Finance - Drug-development company announces the receipt of second extension of funding from Genentech

Finance - Endovascular device company reports Q3 2005 net sales up 70% to $33.5 million

Finance - Pain-management-focused pharmaceutical completes secondary offering

Finance - Pharmaceutical company completes financing to continue development of Parkinson disease drug

Gastroenterology - Patients with IBD experience increased risk for demyelinating diseases

Generic Drugs - U.S. Food and Drug Administration grants final approval of Gabapentin

Genetics & Genomics - Osmolarity regulates gene expression in intervertebral disc cells, RT-PCR study finds

Genetics & Genomics - Researchers discover gene on chromosome 15 that regulates inflammation

Genetics & Genomics - Upregulation of matrix protein transcripts related to atrophic myofibers found in XLMTM

Glioma - PARP inhibition may increase temozolomide efficacy in treatment of malignant gliomas

HIV/AIDS Pathogenesis - Simian immunodeficiency virus disrupts extended lengths of the blood-brain barrier

HIV/AIDS Risk Factors - Requiring help injecting predicts HIV infection incident among intravenous drug users

Head Trauma - Propofol and/or erythropoietin treatment reduces oxidative brain damage in rats

Headache & Migraine - Reproductive hormones and menstrually related distress predict migraine activity

Hemifacial Spasm - Abnormal muscle response monitoring useful during microvascular decompression

Hip Replacement - Computer-assisted arthroplasty not linked to permanent nerve injury

Hormones - Estrogen receptor alpha and beta neurons are co-localized in rat hippocampus

Hypertension - Deep brain stimulation can lower blood pressure

Imaging - Origin of intracanalicular neoplasms predicted with high-resolution MR imaging

Infectious Mononucleosis - Corticosteroids are often used in the treatment of infectious mononucleosis

Intracranial Aneurysm - 4-D CT angiography provides valuable information on aneurysm hemodynamics

Intracranial Aneurysm - Stent-assisted coil embolization effective for wide-necked aneurysms

Labor & Delivery - Acceptable level of maternal and neonate side effects found with patient-controlled analgesia

Labor & Delivery - Paracervical block and OB experience play important role in labor pain relief

Leukemia - Clinical testing approved for therapy of relapsed and refractory leukemias

Mental Health - Drug company awards scholarships to winners who have severe mental illnesses

Mental Health - Hange-koboku-to lowers 5-HT levels, and raises DA and HVA levels in mouse model cerebrum

Metastasis - Single brain metastasis treated with surgery

Migraines - Trexima NDA accepted for review by U.S. Food and Drug Administration

Mitochondrial Disease - Foundation funds first clinical fellowship in mitochondrial medicine

Multiple Sclerosis - Avonex is cost-effective for delaying MS onset after single demyelinating event

Multiple Sclerosis - MS progression may be linked to immune cell substance

Muscular Dystrophy - Development-stage biopharmaceutical submits application for orphan drug status for Myodur

Nanotechnology - U.S. NIH awards $3.7M grant for development of molecular imaging, brain tumor therapy agent

Neurodegenerative Disease - Alpha-synuclein double mutant prevents fibril formation

Neurohypophysis - Case of granular cell tumor of the neurohypophysis reported

Neurology - Cerebellar fastigial nucleus-mediated neurogenic neuroprotection involves mitochondria

Neurology - Endogenous neuregulin restores radial glia in a model of cortical dysplasia

Neurology - H2 O2 activation of p38 MAPK pathway shown to properties in astrocytes

Neurology - NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models

Neurology - Ndrg2 promotes neurite outgrowth of differentiated PC12 cells

Neurology - Opposing actions of glucocorticoids mediate rapid inhibition of magnocellular neuroendocrine cells

Neurology - Response profiles in vomeronasal sensory neurons are heterogeneous

Neurology - Zebrafish model indicates neuronal mechanism for behavioral control

Neuropathy - Novel neuropathic organophoshorus biosensor detects biomarker NTE in blood

Neuroscience - Dr. Peter Vajkoczy presents latest data on Bowman Perfusion Monitoring System

Neuroscience - Nonsynaptic GABAergic signaling exists between neuroblasts and GFAP-expressing cells

Neuroscience - Stimulated expression of dentate gyrus granule cell mu-opioid receptor occurs after focal ischemia

Neuroscience - Use of full-body biomechanics may improve study of motor cortex function

Neuroscience - Your brain cells may know more than you let on by your behavior

Neurosurgery - Codubix polypropylene-polyester knit safe and effective as cranioplasty material

Neurotransmitters - RIM1 alpha PDZ domain forms a complex with an ELKS1 b C-terminal peptide

Ophthalmology - Pattern electroretinography indicates early evidence of inner retinal damage

Ossiculoplasty - Sculpted incus interposition produces hearing comparable with allograft prostheses

Ossiculoplasty - Silastic banding stabilizes ossicular prosthesis in patients with intact stapes and absent malleus

Oxidative Stress - Immobilization stress alters and causes oxidative damage in the nigrostriatal system

Oxidative Stress - Parachlorophenylalanine exacerbates gentamicin-induced oxidative stress

Pain Management - Almost 10 million Britons suffer pain almost daily

Pain Management - Gamma knife is effective in treating trigeminal neuralgia

Pain Management - Magnetic insoles fail to reduce workplace foot pain

Pain Management - Pain minimized in swimmers educated in proper stroke and training techniques

Pain Management - Patients with chronic pain don't have to suffer in silence

Parkinson Disease - Treadmill walking acts as external pacemaker to improve gait stability

Personnel - Pharma company appoints Terrence Moore as vice president

Pharmaceutical Research - Researchers discover previously unknown form of plasticity in nerve cells

Philanthropy - Queensland Brain Institute receives $650,000 spinal research bequest

Physiology - Catecholamines, serotonin, acetylcholine and nitric oxide co-exist in aortic glomus cells

Physiology - Regulation of cyclic GMP levels in olfactory sensory neurons may be crucial in odorant stimulation

Posterior Cortex Epilepsy - Epilepsy duration and neurologic abnormalities predict surgery outcome

Prions - Perineuronal net destruction is caused by the pathogenic effect of prions

Prions - Researchers identify location of cellular prion protein in a rat brain model

Protein Misfolding - Phase I study begins with Fx-1006a, to stabilize protein misfolding in hereditary amyloid disorders

Psoriasis - Study to measure safety and efficacy of immunomodulator in psoriasis patients

Quality Assurance - Biotech holding company announces facilities GMP-certified for drug production

Radiosurgery - Vestibular schwannomas successfully treated with gamma knife radiosurgery (GKRS)

Radiotherapy - Radiotherapy could be deferred for low-grade glioma patients in good condition

Receptors - Huperzine A protects neuroblastoma cells against oxidative stress damage

Regulatory Approval - IGRT receives regulatory approval in Canada

Reproduction - Gonadotropin-releasing hormone secretion is regulated by cannabinoids

Rett Syndrome - RSRF-funded research reveals novel function for Rett syndrome gene

Rheumatoid Arthritis - Data suggest that 2ME2 inhibits inflammation and disease progression in rheumatoid arthritis model

Schizophrenia - Myelin-associated glycoprotein genotype linked to schizophrenia in Chinese Han

Schizophrenia - Neural development protein proves not to be a marker for schizophrenia

Shoulder Replacement - Prosthesis migration impairs function in avascular necrosis but not osteoarthritis patients

Sick Worker Syndrome - Repetitive strain syndrome injuries can cause sick worker syndrome

Sickle Cell Disease - Inhaled nitric oxide may help sickle cell disease

Spinal Cord Injury - Survey reveals many Hispanics in U.S. not aware of available paralysis resources

Spine Surgery - Anterior iliac crest reconstruction reduces pain after bone graft harvest

Stapes Fixation - Stapedotomy feasible for osteogenesis imperfecta patients

Stem Cell Proliferation - Low power laser radiation stimulates stem cell proliferation rate during tissue regeneration

Stem Cell Research - Confirmed survival and differentiation of ESC-derived NPCs transplanted into ischemic brain

Stem Cell Research - Extracellular signal-regulated kinase/MAPK induces neuronal markers in MSCs

Stem Cell Research - Increased TCF/beta-catenin/CBP-mediated transcription decreases neuronal differentiation

Stem Cell Research - Neural stem cells partition DNA asymmetrically

Stem Cell Research - Radial cells in the spinal cord are precursors to radial glia

Stem Cell Research - Studies show immature stem cells proliferate, create multiple types of neural cells

Stem Cell Transplantation - BM stromal cell treatment improves neurologic recovery in autoimmune encephalomyelitis

Stroke - Balance between antioxidants and by-products of oxidative stress may be best stroke marker

Suicide - New study reveals attempted suicide often a snap decision fuelled by drugs and alcohol

Surgery - Comorbidity impacted survival after surgical resection of lung cancer

Surgical Technology - Non-stick bipolar forceps launched for neurosurgery

Systemic Lupus Erythematosus - LymphoStat-B shown to be safe, well-tolerated in patients with systemic lupus erythematosus

Tobacco Use - U.S. Department of Defense funds research on how nicotine impairs bone healing

Urology - Bladder smooth muscle cells exhibit hypertrophy, not hyperplasia, following spinal cord injury

Vaccine Safety - Newest study finds no link between MMR vaccine and autism

Varicose Veins - Varicose veins successfully treated once pelvic symptoms treated

Vector Development - Herpes virus amplicon vectors are useful in studies of brain disorders

West Nile Virus - Focus and Panbio flavivirus enzyme immunoassays useful for diagnosis

Zoonosis - Elk chronic wasting disease prions not transmissible to humans

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