Susan Hasty, Publisher
Table of Contents . . . November 7th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Anesthesiology - Near infrared laser device can measure brain oxygen levels during surgery
Apoptosis - Mitochondrial impairment is induced in cortical neurons after oxygen and glucose deprivation
Drug Abuse - Texas researchers find alterations in brain's circuitry caused by cocaine
Neuroscience - Ependymomas in other CNS locations appear to arise from radial glia cells
Pain Management - Local anesthetics are effective for neuropathic pain
Addiction Medicine - Beta-carbolines block opiate withdrawal
Adverse Drug Reaction - Case study suggests hydroxyurea therapy may be implicated in neuroendocrine carcinoma
Adverse Drug Reaction - Imidazenil antagonizes sedative but not anticonvulsant diazepam activity
Alcohol Use - Evodiae fructus extracts promote expression of anti-hangover enzymes
Alzheimer Disease - Amyloid beta proteins promote oxidative lipid membrane damage
Alzheimer Disease - Clinical development commences for AZD-103 for Alzheimer disease
Alzheimer Disease - Dementia research provides hope for the future
Alzheimer Disease - New alliance signed regarding genetic research program for Alzheimer disease
Alzheimer Disease - Study shows protein test improves early detection, diagnosis of Alzheimer disease
Alzheimer Disease - Widespread protein insolubility detected early in Alzheimer disease
Amyloid Fibrils - Association of beta2 -microglobulin amyloid fibrils is thermally controlled
Analgesia - Pain scores look similar in patients given different liver biopsy procedures
Analgesia - Rat/mouse hemokinin-1 may have a crucial role in pain modulation
Anesthesia - Tiny worms paving way for better anesthetics
Anesthetics - GABA and opioid peptide receptors are involved in sevoflurane-induced spinal cord antinociception
Angiology - Endothelin-1 and endothelin receptors are over-expressed in retinal degeneration
Antidepressants - Continuous paroxetine treatment reduces SERT ligand binding sites and protein expression
Antipsychotic Drugs - Atypical antipsychotics for dementia may result in increased risk of death
Apoptosis - Low-dose cisplatin protects neuroblastoma SH-SY5Y cells from paclitaxel-induced apoptosis
Arthritis - Calcitonin gene-related peptide and TRPV1 may contribute to osteoarthritis pain
Arthritis - U.S., E.U. regulatory submission made seeking approval of Humira in ankylosing spondylitis
Atherosclerosis - Review discusses the 5-lipoxygenase - atherosclerosis connection
Awards - Neuroscientist Antonio Damasio receives Prince of Asturias prize
Back Pain - Search engine offers public information on spinal surgeries and back pain
Basilar Artery Occlusion - Endovascular mechanical thrombus extraction may be superior to thrombolysis
Biomedical Engineering - CT and foreign-body giant cell values higher in 30% than in 10% BaSO4 /PMMA, sheep model shows
Biowarfare - Hapten that hydrolyzes nerve agent has been developed
Bone Formation - Sclerostin is an osteocytic product that inhibits bone formation
Brain Cancer - Cytokines maintain neovascular growth in gliomas subjected to hypoxia
Business & Finance - Judith Gwathmey selected for U.S. National Institutes of Health program
Calcific Tendinitis - Computer-assisted 3-D navigation improves extracorporeal shock wave efficacy
Cancer Coping - Illness-related problems and coping among persons with low-grade glioma examined
Cancer Pain - Pancreatic cancer pain managed by either of two invasive techniques
Cancer Therapy - Cisplatinum re-challenge overcame carboplatin hypersensitivity
Cancer Therapy - Curcumin abolishes aberrant enzyme expression in brain tumor cells
Cancer Therapy - Endocrine late effects occurred from multi-modality treatment of neuroblastoma
Cancer Therapy - European marketing authorization application withdrawn for Revaproxyn
Cancer Therapy - Pyrazoloacridine and carboplatin used in phase I/II trial for recurrent glioma
Cancer Therapy - Registry launched for head and neck cancer patients
Cardiology - Cardiac valve pathology may be risk factor for several types of CNS involvement
Cardiology - Three-year trials demonstrate carotid stent durability in preventing stroke
Cardiovascular Research - Fibromyalgia patients have enhanced CV sympathetic activity while recumbent
Cardiovascular Research - Nervous regulation of atrial vs. ventricular vessels is highly differentiated
Cardiovascular Research - QRS shortening in tetralogy of Fallot is related with better exercise performance
Carotid Artery Disease - Simulation provider introduces training product for carotid stenting
Carotid Artery Stenosis - Novel scoring system predicts prolonged hypotension after carotid stenting
Cerebral Palsy - Shank muscles have reduced EMG during gait, while hamstrings show enhanced activation
Cerebrospinal Fluid - Near infrared fluorescence can image cerebrospinal fluid space and movement
Clinical Trials - Next clinical trial of drug injected into inflamed arthritic joints initiated
Clinical Trials - Twenty-six year data support efficacy, safety of Copaxone in relapsing-remitting MS
Cochlear Implants - Targeted phoneme training may hasten adaptation to spectrally shifted speech
Collaborations - Alliance to focus on development of anti-rheumatic agent in Japan
Craniopharyngioma - Fronto-basal approach effective for tumors extending outside suprasellar cistern
Cytology - Lipophilic ion modulator DP-109 membrane insertion involves membrane potential interactions
Dementia - Selegiline, alone or with donepezil, reduces memory impairment in rats
Depression - Cigna: Direct costs of depression in the workplace are tip of the iceberg
Depression Therapy - Long-term antidepressant treatment alters lipid composition of brain plasma membranes
Diagnostics - Companies team up to provide hs-CRP test for clinical trial recruitment and screenings
Diagnostics - Doctors are advised to carefully assess causes of traumatic brain injury in children
Diagnostics - Magnetic resonance spectroscopy differentiates high and low grade brain tumors
Diagnostics - Major depression predicts higher mortality following stem cell transplantation
Diet & Nutrition - Model designed to evaluate policies that influence population fish consumption
Disease Associations - Myristoyltransferase expression elevated in epilepsy
Drug Delivery - Lipophilic counter-ions improve benzydamine membrane diffusion
Drug Development - Biotech company to focus on developing hepatitis C, arthritis, CF drugs
Drug Development - Multiple dose study initiated for AEOL 10150 in patients with amyotrophic lateral sclerosis
Drug Development - Novel potent and selective MMP-13 inhibitors synthesized
Drug Development - Petition submitted to U.S. FDA for more rigorous bioequivalence testing for generic Adderall XR
Drug Development - Three new sites added to Indaflex phase II trial for osteoarthritis of the knee
Drug Development - U.S. FDA grants clearance to initiate phase II trials for abuse-resistant, extended-release opioid
Dystonia - Dystonia affects up to a quarter million people in the United States
Endometriosis - Practitioners need more training to provide diagnosis and support for women with endometriosis
Environmental Health - p,p'-DDE treatment appears to increase aromatase activity in ESC in culture
Facilities - TGen and St. Joseph's launch Pediatric Neurogenetics Center
Finance - Drug development company reports placement of $40 million of convertible notes
Finance - Drug-development company announces the receipt of second extension of funding from Genentech
Finance - Endovascular device company reports Q3 2005 net sales up 70% to $33.5 million
Finance - Pain-management-focused pharmaceutical completes secondary offering
Finance - Pharmaceutical company completes financing to continue development of Parkinson disease drug
Gastroenterology - Patients with IBD experience increased risk for demyelinating diseases
Generic Drugs - U.S. Food and Drug Administration grants final approval of Gabapentin
Genetics & Genomics - Osmolarity regulates gene expression in intervertebral disc cells, RT-PCR study finds
Genetics & Genomics - Researchers discover gene on chromosome 15 that regulates inflammation
Genetics & Genomics - Upregulation of matrix protein transcripts related to atrophic myofibers found in XLMTM
Glioma - PARP inhibition may increase temozolomide efficacy in treatment of malignant gliomas
HIV/AIDS Pathogenesis - Simian immunodeficiency virus disrupts extended lengths of the blood-brain barrier
HIV/AIDS Risk Factors - Requiring help injecting predicts HIV infection incident among intravenous drug users
Head Trauma - Propofol and/or erythropoietin treatment reduces oxidative brain damage in rats
Headache & Migraine - Reproductive hormones and menstrually related distress predict migraine activity
Hemifacial Spasm - Abnormal muscle response monitoring useful during microvascular decompression
Hip Replacement - Computer-assisted arthroplasty not linked to permanent nerve injury
Hormones - Estrogen receptor alpha and beta neurons are co-localized in rat hippocampus
Hypertension - Deep brain stimulation can lower blood pressure
Imaging - Origin of intracanalicular neoplasms predicted with high-resolution MR imaging
Infectious Mononucleosis - Corticosteroids are often used in the treatment of infectious mononucleosis
Intracranial Aneurysm - 4-D CT angiography provides valuable information on aneurysm hemodynamics
Intracranial Aneurysm - Stent-assisted coil embolization effective for wide-necked aneurysms
Labor & Delivery - Acceptable level of maternal and neonate side effects found with patient-controlled analgesia
Labor & Delivery - Paracervical block and OB experience play important role in labor pain relief
Leukemia - Clinical testing approved for therapy of relapsed and refractory leukemias
Mental Health - Drug company awards scholarships to winners who have severe mental illnesses
Mental Health - Hange-koboku-to lowers 5-HT levels, and raises DA and HVA levels in mouse model cerebrum
Metastasis - Single brain metastasis treated with surgery
Migraines - Trexima NDA accepted for review by U.S. Food and Drug Administration
Mitochondrial Disease - Foundation funds first clinical fellowship in mitochondrial medicine
Multiple Sclerosis - Avonex is cost-effective for delaying MS onset after single demyelinating event
Multiple Sclerosis - MS progression may be linked to immune cell substance
Muscular Dystrophy - Development-stage biopharmaceutical submits application for orphan drug status for Myodur
Nanotechnology - U.S. NIH awards $3.7M grant for development of molecular imaging, brain tumor therapy agent
Neurodegenerative Disease - Alpha-synuclein double mutant prevents fibril formation
Neurohypophysis - Case of granular cell tumor of the neurohypophysis reported
Neurology - Cerebellar fastigial nucleus-mediated neurogenic neuroprotection involves mitochondria
Neurology - Endogenous neuregulin restores radial glia in a model of cortical dysplasia
Neurology - H2 O2 activation of p38 MAPK pathway shown to properties in astrocytes
Neurology - NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models
Neurology - Ndrg2 promotes neurite outgrowth of differentiated PC12 cells
Neurology - Opposing actions of glucocorticoids mediate rapid inhibition of magnocellular neuroendocrine cells
Neurology - Response profiles in vomeronasal sensory neurons are heterogeneous
Neurology - Zebrafish model indicates neuronal mechanism for behavioral control
Neuropathy - Novel neuropathic organophoshorus biosensor detects biomarker NTE in blood
Neuroscience - Dr. Peter Vajkoczy presents latest data on Bowman Perfusion Monitoring System
Neuroscience - Nonsynaptic GABAergic signaling exists between neuroblasts and GFAP-expressing cells
Neuroscience - Stimulated expression of dentate gyrus granule cell mu-opioid receptor occurs after focal ischemia
Neuroscience - Use of full-body biomechanics may improve study of motor cortex function
Neuroscience - Your brain cells may know more than you let on by your behavior
Neurosurgery - Codubix polypropylene-polyester knit safe and effective as cranioplasty material
Neurotransmitters - RIM1 alpha PDZ domain forms a complex with an ELKS1 b C-terminal peptide
Ophthalmology - Pattern electroretinography indicates early evidence of inner retinal damage
Ossiculoplasty - Sculpted incus interposition produces hearing comparable with allograft prostheses
Ossiculoplasty - Silastic banding stabilizes ossicular prosthesis in patients with intact stapes and absent malleus
Oxidative Stress - Immobilization stress alters and causes oxidative damage in the nigrostriatal system
Oxidative Stress - Parachlorophenylalanine exacerbates gentamicin-induced oxidative stress
Pain Management - Almost 10 million Britons suffer pain almost daily
Pain Management - Gamma knife is effective in treating trigeminal neuralgia
Pain Management - Magnetic insoles fail to reduce workplace foot pain
Pain Management - Pain minimized in swimmers educated in proper stroke and training techniques
Pain Management - Patients with chronic pain don't have to suffer in silence
Parkinson Disease - Treadmill walking acts as external pacemaker to improve gait stability
Personnel - Pharma company appoints Terrence Moore as vice president
Pharmaceutical Research - Researchers discover previously unknown form of plasticity in nerve cells
Philanthropy - Queensland Brain Institute receives $650,000 spinal research bequest
Physiology - Catecholamines, serotonin, acetylcholine and nitric oxide co-exist in aortic glomus cells
Physiology - Regulation of cyclic GMP levels in olfactory sensory neurons may be crucial in odorant stimulation
Posterior Cortex Epilepsy - Epilepsy duration and neurologic abnormalities predict surgery outcome
Prions - Perineuronal net destruction is caused by the pathogenic effect of prions
Prions - Researchers identify location of cellular prion protein in a rat brain model
Protein Misfolding - Phase I study begins with Fx-1006a, to stabilize protein misfolding in hereditary amyloid disorders
Psoriasis - Study to measure safety and efficacy of immunomodulator in psoriasis patients
Quality Assurance - Biotech holding company announces facilities GMP-certified for drug production
Radiosurgery - Vestibular schwannomas successfully treated with gamma knife radiosurgery (GKRS)
Radiotherapy - Radiotherapy could be deferred for low-grade glioma patients in good condition
Receptors - Huperzine A protects neuroblastoma cells against oxidative stress damage
Regulatory Approval - IGRT receives regulatory approval in Canada
Reproduction - Gonadotropin-releasing hormone secretion is regulated by cannabinoids
Rett Syndrome - RSRF-funded research reveals novel function for Rett syndrome gene
Rheumatoid Arthritis - Data suggest that 2ME2 inhibits inflammation and disease progression in rheumatoid arthritis model
Schizophrenia - Myelin-associated glycoprotein genotype linked to schizophrenia in Chinese Han
Schizophrenia - Neural development protein proves not to be a marker for schizophrenia
Shoulder Replacement - Prosthesis migration impairs function in avascular necrosis but not osteoarthritis patients
Sick Worker Syndrome - Repetitive strain syndrome injuries can cause sick worker syndrome
Sickle Cell Disease - Inhaled nitric oxide may help sickle cell disease
Spinal Cord Injury - Survey reveals many Hispanics in U.S. not aware of available paralysis resources
Spine Surgery - Anterior iliac crest reconstruction reduces pain after bone graft harvest
Stapes Fixation - Stapedotomy feasible for osteogenesis imperfecta patients
Stem Cell Proliferation - Low power laser radiation stimulates stem cell proliferation rate during tissue regeneration
Stem Cell Research - Confirmed survival and differentiation of ESC-derived NPCs transplanted into ischemic brain
Stem Cell Research - Extracellular signal-regulated kinase/MAPK induces neuronal markers in MSCs
Stem Cell Research - Increased TCF/beta-catenin/CBP-mediated transcription decreases neuronal differentiation
Stem Cell Research - Neural stem cells partition DNA asymmetrically
Stem Cell Research - Radial cells in the spinal cord are precursors to radial glia
Stem Cell Research - Studies show immature stem cells proliferate, create multiple types of neural cells
Stem Cell Transplantation - BM stromal cell treatment improves neurologic recovery in autoimmune encephalomyelitis
Stroke - Balance between antioxidants and by-products of oxidative stress may be best stroke marker
Suicide - New study reveals attempted suicide often a snap decision fuelled by drugs and alcohol
Surgery - Comorbidity impacted survival after surgical resection of lung cancer
Surgical Technology - Non-stick bipolar forceps launched for neurosurgery
Systemic Lupus Erythematosus - LymphoStat-B shown to be safe, well-tolerated in patients with systemic lupus erythematosus
Tobacco Use - U.S. Department of Defense funds research on how nicotine impairs bone healing
Urology - Bladder smooth muscle cells exhibit hypertrophy, not hyperplasia, following spinal cord injury
Vaccine Safety - Newest study finds no link between MMR vaccine and autism
Varicose Veins - Varicose veins successfully treated once pelvic symptoms treated
Vector Development - Herpes virus amplicon vectors are useful in studies of brain disorders
West Nile Virus - Focus and Panbio flavivirus enzyme immunoassays useful for diagnosis
Zoonosis - Elk chronic wasting disease prions not transmissible to humans
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