Prions
Perineuronal net destruction is caused by the pathogenic effect of prions
Published in Pain and Central Nervous System Week, November 7th, 2005
"The PrPC is a membrane-bound glycoprotein mainly present in the CNS. The scrapie prion protein (PrPSc) is an isoform of PrPC, and it is responsible for transmissible spongiform encephalopathies (TSEs), a group of neurodegenerative diseases affecting both humans and animals.
"The presence of the cellular form is necessary for the establishment and further evolution of prion diseases. Here, we map the regional distribution of PrPC in the rat brain and study the chemical nature of these immunopositive...
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