Drug Abuse

Texas researchers find alterations in brain's circuitry caused by cocaine

Published in Pain and Central Nervous System Week, November 7th, 2005

Cocaine causes specific alterations in the brain's circuitry at a genetic level, including short-term changes that result in a high from the cocaine, as well as long-term changes seen in addiction, researchers from University of Texas (UT) Southwestern Medical Center have found.

Such findings suggest possible new directions for treatments for addiction to the drug, they said.

In a study available online and in the journal Neuron, UT Southwestern researchers used rodents to pinpoint an important molecular mechanism that switches genes "on" in the part of the brain involved in drug-induced rewards. They also determined that cocaine, through a...

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Source: Pain and Central Nervous System Week (2005-11-07)

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