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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . November 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Cancer Therapy - Central nervous system chemoprophylaxis in non-Hodgkin lymphoma requires standardization

Genetics & Genomics - Variation in genes influences clinical response to morphine

Neurology - T-lymphocyte movement through blood-central nervous system barrier is reviewed

Neuroscience - Scientists study chemical preconditioning as a way to help nerve cells withstand toxic attack, preserve function

Pain Management - Flavonoid treatment has little impact on pain or bleeding after ambulatory stapled hemorrhoidopexy

Addiction Medicine - Constella Group awarded $25 million contract to help prevent substance abuse

Addiction Medicine - Hythiam expands to Utah; PROMETA protocols now offered to patients at Cirque Lodge

Addiction Medicine - U.S. Institute of Medicine issues report on mental illnesses and drug addictions

Alzheimer Disease - Acute gamma-secretase inhibition improves contextual fear conditioning in mice

Alzheimer Disease - Fluorinated stilbene derivatives show promise for PET imaging of beta-amyloid plaques

Alzheimer Disease - Help is just a phone call away for individuals affected by memory loss

Neurology - New findings in neurology described

Alzheimer Disease - High-resolution serum proteomic profiling developed for Alzheimer disease detection

Alzheimer Disease - New scrapbooking approach to help families affected by Alzheimer disease

Alzheimer Disease Vaccine - Adenovirus vector induced an anti-inflammatory immune response

Alzheimer Disease Vaccine - Aldolase is target antigen in Alzheimer disease

Anesthesia - Anesthesia with pentobarbital rather than ketamine/xylazine may be preferred for echocardiography

Apoptosis - Immunosuppression by morphine-induced lymphocyte apoptosis did not occur

Neuroscience - Researchers publish new studies and findings in the area of neuroscience

Arthritis - Lifestyle choices may help control arthritis pain

Attention Deficit Hyperactivity Disorder - SPARLON, for treatment of ADHD in children and adolescents, receives approvable letter

Attention-Deficit Hyperactivity Disorder - Medication patch shown effective for attention-deficit hyperactivity disorder

Awards - LSU researcher receives $485,000 U.S.NIH grant to study Friedreich's ataxia

Back Pain - Stimulation system launched to diagnosing back and neck pain

Biomaterial - Osteogenic protein 1 putty may improve bone autograft outcome in lumbar fusion

Neuroscience - Studies advance knowledge in neuroscience research

Biomedical Engineering - Electrostatic microactuators were developed for neural microelectrode positioning

Bioterrorism - U.S. grants $20 million for developing compounds to treat radiation damage

Bipolar Depression - Development agreement to fund drug trial for bipolar depression

Botulism - Mass spectrometric method developed to differentiate botulinum neurotoxins

Brain Cancer - Chest CT and brain MRI provide optimal evaluation of patients with newly detected brain mass

Brain Cancer Therapy - Pemetrexed has limited distribution to brain

Brain Injury - Rat study of blood substitute in traumatic brain injury shows positive results

Business & Finance - Biotechnology company requests reconsideration pending delisting from Nasdaq

Cancer Clinical Trials - Recommended phase II dose for T900607 determined

Cancer Pain Management - Age and tumor type significantly influence transdermal fentanyl absorption

Cancer Risk Factors - Cell phone use not related to risk of acoustic neuroma

Cancer Therapy - Reports add new data to cancer therapy research

Cancer Therapy - Second-line chemotherapy showed modest activity in patients with hormone-refractory prostate cancer

Cardiomyocytes - Recent studies add new data to cardiomyocytes research

Cardiomyopathy - Valsartan decreases type I collagen synthesis in patients with hypertrophic cardiomyopathy

Cardiovascular Research - Propranolol inhibits the human ether-a-go-go-related gene potassium channels

Carpal Tunnel Syndrome - Topical analgesic patch effective in reducing pain of carpal tunnel syndrome

Cell Development - Sonic hedgehog is required for cardiac outflow tract and neural crest cell development

Cell Physiology - Hyperpolarization-activated cyclic nucleotide-gated channels are modulated by Src kinase

Chemotherapy - Chemotherapy induced toxic myelopathy

Chemotherapy - Intracavitary chemotherapy used to treat recurrent glioblastoma

Chemotherapy - Razoxane was combined with radiotherapy for treatment of melanoma brain metastases

Clinical Trials - Phase I study begins of triple reuptake inhibitor for major depression

Clinical Trials - Positive preliminary results reported from trial of inhaled narcotic analgesics

Contracts - Health software company signs $1.2 million contract with Sweetser

Coronary Artery Bypass - Radial artery harvesting doesn't cause neurologic hand dysfunction

Dental Care - Clinical pediatric study supports benefits of CompuDent in administering anesthetic injections to children

Dermatology - Three studies show investigational psoriasis therapy may be effective option

Developmental Biology - fgf8 signaling functions in left-right patterning of visceral organs and craniofacial skeleton

Diagnostics - Brain abscess and cystic brain tumor discriminated with perfusion MRI

Diagnostics - HPLC method simultaneously detects four antiepiletic drugs in human serum

Diagnostics - MDCT angiography replacing catheter angiography as initial evaluation standard

Diagnostics - MRI visual rating scale improves assessment of cholinergic pathway hyperintensities

Diagnostics - Minimally invasive breath ammonia test not suitable for diagnosis

Diet & Exercise - Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels

Disease Associations - Duplications and copy number variants of 8p23.1 are studied in heart defects

Drug Delivery - Novel microemulsion system shows promise for transdermal aceclofenac delivery

Drug Development - Atypical antipsychotics based on 8-substituted 3,4-dihydroquinolinones show promise

Drug Development - Lilly to support study of antagonist to curb weight gain from antipsychotic drugs

Drug Safety - High doses of ibuprofen can cause significant GI bleeding despite its safety profile

Electroencephalography - Independent component analysis improved recognition rates for four classifiers

Embolism - Cerebral embolism occurred after transcatheter arterial chemoembolization

Endocrinology - Neuroblasts migrate in response to endothelin-1 through involvement of endothelin type B receptors

Endocrinology - Travelers can avoid jet lag by resetting their body clocks

Epilepsy - Application filed for treatment of myclonic seizures in juveniles

Finance - Cancer vaccine maker records loss of $0.60 per share

Finance - Drug developer raises $29.4 million in series A financing

Finance - Medical device company reports 3 month revenue of $9.1 million

Generic Drugs - California pharma company authorized to distribute generic oxycodone tablets

Genetics & Genomics - Hippocampus and amygdala have distinct genomic responses to fear conditioning

Genetics & Genomics - Novel molecular karyotyping system submicroscopic chromosome alterations

Genetics & Genomics - Tryptophan hydroxylase 2 gene variants are associated with ADHD

Geriatrics - Survey reveals older Americans' attitudes toward sleep and healthy aging

Glioblastoma - Kinase genes are amplified in highly vascular brain tumors

Granulocytic Sarcoma - Granulocytic sarcoma manifested as multiple skeletal lesions

HIV/AIDS Pathogenesis - Research add new data to HIV/AIDS pathogenesis body of knowledge

Heart Failure - CorCap cardiac support device improves surgical outcome in patients with cardiomyopathy

Hospice - Patients indicated a dislike for questionnaires

Hypoxia - Supercooling varies glycogen, free glucose, and lactate in organs of Chrysemys picta

Imaging - Lesion size determines imaging accuracy

Imaging - fMRI reveals alteration of spatial working memory networks across adolescence and gender

Immunization - Immunization awareness organization supporting Tdap booster

Immunology - Recent findings in immunology provide new insights

Infections - Adequate control of postoperative pain prevented infections after lung cancer surgery

Influenza - Children with neurological and neuromuscular diseases should receive annual flu shot

Influenza - Neurological disease raises the risk of complications from flu

Ischemia - Heat stress increases the effectiveness of early ischemic preconditioning in spinal cord protection

Ischemia - Plaminogen activator gene polymorphism influences ischemic stroke

Medical Devices - Cochlear implantation improves speech capabilities in pediatric patients

Medical Devices - Medical technology company enhances monitoring of patient-controlled analgesia

Mental Health - Alzheimer's Foundation of America offers post-hurricane coping techniques

Mental Health - Developer of oxidative stress disorders treatments demonstrates mammalian aging is under the control of CLK-1 activity

Mental Health - University study shows genetic trigger is behind some cases of schizophrenia

Migraine Therapy - Oral naratriptan is effective for treatment of menstrually related migraine

Multiple Sclerosis - Animal model study shows drug compound effective on multiple sclerosis

Multiple Sclerosis Vaccine - IVIG reduces neurological abnormalities when given prophylactically

Muscular Dystrophy - New muscular dystrophy cooperative research centers are announced

Myocardial Infarction - Morphine enhances isoflurane-induced postconditioning against myocardial infarction

NeuroAIDS - 6-Chloro-2',3'-dideoxyguanosine decreases C1q synthesis and SIV burden in neuroAIDS

NeuroAIDS - Lithium protects neurons from secretions of HIV-1-infected monocyte-derived macrophages

Neurology - Findings in neurology provide new insights

Neurology - Generalized cable equation model developed for myelinated nerve fiber

Neurology - Novel rat model of mild cerebral concussion injury reveals impaired spatial learning

Neurology - Ras/MEK pathway is required for coordinate expression of GCH and TH genes in PC12D cells

Neurology - Retinal degeneration caused by rd1 mutation effects hyppocampal-dependent learning in mice

Neurology - Two antiphase oscillations occur in SCN of behaviorally split hamsters

Neurology - Ultrasound accelerated nerve regeneration when cells were seeded with PLGA conduits

Neurology - Vestibular vertigo may be common in the general population

Neuroscience - Apelin counteracts vasopressin secretion

Neuroscience - Dendrite changes may be involved in learning

Neuroscience - Pallidal neuron firing rates similar in Huntington and Parkinson disease patients

Neuroscience - People can rapidly reshape motor generalization to best learn a new movement task

Neuroscience - Researchers detail new studies and findings in the area of neuroscience

Neuroscience - The angiogenic chemokine CXCL12 has prognostic value in low-grade gliomas

Obesity - Findings help understanding of brain pathways' role in obesity development

Ophthalmology - Intraocular pressure must be considered when assessing glaucoma risk and corneal thickness

Ophthalmology - Neural networks may distinguish normal and glaucomatous visual fields

Ophthalmology - Pharma company executes agreement to promote treatment for dry eye disease

Opioids - Use of multiple opioids can lead to increased risk for dosing errors

Orthopedics - New licensing agreements to develop spacer implants for arthritis treatment

Orthopedics - Orthopedics-focused spine non-fusion company changes name to Paradigm Spine, LLC

Osteoarthritis - Blood-based osteoarthritis biomarker paper published

Pain Management - Arthroscopic treatment improves stability and reduces pain

Pain Management - Drug infusion systems company launches line of electronic infusion pumps

Pain Management - Etoricoxib provides safe and effective analgesia after joint replacement surgery

Pain Management - Marketing application submitted for U.K. approval of injectable pain treatment

Pain Management - Sonography-guided iliopsoas peritendinous injections have diagnostic and therapeutic utility

Palliative Care - Methotrimeprazine used in management of nausea and vomiting in advanced cancer

Parkinson Disease - Protein known to cause neurodegeneration may, at normal levels, offer protection

Parkinson Disease - Stem cell implantation shows beneficial effect on Parkinson disease

Patents - Lexapro patent litigation trial date rescheduled to March 15, 2006

Pediatric Neurology - Mechanisms that govern ICP may be disrupted during traumatic brain injury

Pediatric Stroke - Pediatric stroke protocol developed at Pennsylvania hospital

Philanthropy - Johnson & Johnson awards $40,000 to Hawaiian nonprofit to promote AAC device use by children

Physiology - Osmosensitive mechanisms contribute to the water drinking-induced pressor response in humans

Physiology - Researchers publish new studies and findings in the area of physiology

Postherpetic Neuralgia - Enrollment complete for phase II clinical trial for Gabapentin GR

Prions - Studies advance knowledge in prions research

Product Licensing - License agreement signed to develop and commercialize Aurora kinase inhibitors

Proteomics - German biotech company reports validation of therapeutic, anti-inflammatory NBE Protease in vivo

Proteomics - Researchers detail new studies and findings in the area of proteomics

Rheumatoid Arthritis - Butyrate appears to regulate TNFa at the mRNA level, making it a potential RA therapy

Rheumatoid Arthritis - Opposite immune responses explain different therapeutic effects in rheumatoid arthritis

Rheumatoid Arthritis - Synovial proteome microarrays provide diagnostic information for RA

Rhinitis - PreHistin significantly reduces allergy symptoms in 714-patient phase III clinical trial

Spinal Cord Injury - Antibody to IL-6R suppresses secondary injury and glial scar formation in spinal cord injury

Spinal Cord Injury - UCB transplantation improves functional recovery after spinal cord injury

Spinal Surgery - Company reports 100 have received implantable cervical artificial disc

Spinal Surgery - Spinal technology company reports 100 surgeons trained to use screw placement device

Stem Cell Disorders - Telomerase activity in MDS may be insufficient to compensate for telomere shortening

Stem Cell Research - Chronic intrathecal injections of a large volume of fluid increase mast cells in the CNS

Stem Cell Research - Clearance granted for phase I trial of neural stem cells to treat Batten disease

Stem Cell Research - Neural stem cell differentiation is dependent upon endogenous caspase-3 activity

Stem Cell Research - Neuroprotection by stem cell factor in cortical neurons involves Akt and NF kappa B

Stroke - NCAM-derived peptide FGL protects neurons from ischemic injury

Stroke - Women receive fewer diagnostic tests for ischemic stroke than men

Surgical Technology - 3D CT angiography of internal carotid artery facilitates endoscopic approach

Surgical Technology - Modified implantation approach preserves residual deep frequency hearing

Surgical Technology - New surgery technique used to remove formerly inoperable tumors from the cervical spine

Surgical Technology - Practice advisory on intraoperative awareness and brain function monitoring adopted

Surgical Technology - Single-photon emission CT and balloon occlusion show comparable hypoperfusion

Type 2 Diabetes - Over 60% of type 2 diabetics in Dallas, Texas, study missed blood sugar target

Urology - Heart rate variability in female patients with overactive bladder differs from normal controls

Urology - Percutaneous nerve stimulation leads have high bacterial contamination rate

Vaccines Vector - Researchers' data advance vaccines vector research

Vasculitis - Patients with hepatitis C-associated nerve lesions have altered immune response factors

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