Cell Physiology
Hyperpolarization-activated cyclic nucleotide-gated channels are modulated by Src kinase
Published in Pain and Central Nervous System Week, November 21st, 2005
"HCN1-4 play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in brain and heart," wrote X.G. Zong and colleagues, Chinese Academy of Science.
"HCN channels are principally activated by membrane hyperpolarization and binding of cAMP. Here, we identify Tyr phosphorylation by Src kinase as another mechanism affecting channel gating.
The researchers wrote, "Inhibition of Src by specific...
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