Susan Hasty, Publisher
Table of Contents . . . January 23rd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Alzheimer Disease - Gold nanoparticles, radiation combination may slow AD progression
Alzheimer Disease - Reduced brain volume may predict Alzheimer risk
Autism - Variations in the serotonin transporter are associated with autism
Fibromyalgia - Characterization and consequences of pain variability studied in individuals with fibromyalgia
Stroke - Laser technique sheds light on small strokes implicated in dementia
Addiction Medicine - Adolescent research animals are more sensitive to handling experience than adults
Addiction Medicine - Agency issues approvable letter for Vivitrol for treatment of alcohol dependence
Addiction Medicine - Different drugs produce attention and motivation deficits in rats
Addiction Medicine - MRI findings are key to a leukoencephalopathy diagnosis caused by drug use
Alzheimer Disease - A-beta-degrading enzymes are targets for therapeutic intervention in Alzheimer disease
Alzheimer Disease - Drugmaker applies for a new indication of severe Alzheimer disease for Aricept in Japan
Alzheimer Disease - Imaging study links key genetic risk for AD to myelin breakdown
Alzheimer Disease - Insulin and cholesterol are important for normal neuronal function and AD pathways
Alzheimer Disease - New findings in the area of Alzheimer Disease described
Alzheimer Disease - Researchers show astrocytes directly control blood flow in brain
Anesthesia - Clonidine reduces post-anesthesia agitation in children
Anesthesia - Lidocaine and mexiletine were safe and relieved neuropathic pain better than placebo
Aneurysms - Balloon occlusion testing helps determine PICA segment involvement
Angiology - Clinical symptoms announce arcuate ligament vascular compression syndrome in children
Angiology - Sufentanil has direct vasodilatory effect on vascular tissue
Antisense Technology - Nuclear receptor 5a2 functions in skeletal muscle organization
Antisense Technology - Smad-interacting protein regulates chordin expression in the Xenopus embryo
Apoptosis - A better understanding of the pathways governing apoptosis may yield new targets for therapy
Arthritis - Stepwise autoantibody testing can be used to distinguish RA patients at risk for poor outcome
Attention Deficit Hyperactivity Disorder - U.S. FDA issues approvable letter for Daytrana methylphenidate transdermal system
Autism - Senate bill grants drug companies immunity from liability for injuries caused by vaccines
Behavioral Medicine - Florida behavioral healthcare provider licenses physiological substance abuse protocols
Botulism Vaccine - Anti-neurotoxin antibody production is enhanced by subcomponents of C. botulinum hemagglutinin
Brain Cancer - Ability of MET-PET to diagnose dysembryoplastic neuroepithelial tumors assessed
Brain Cancer - Radiosurgery for metastatic brain cancer discussed
Brain Cancer - Reports describe recent advances in Brain Cancer research
Brain Cancer - Surgery for primary brain tumors indicated quality of U.S. academic training
Breast Cancer Therapy - Mental health plays strong role in chemotherapy-related fatigue in breast cancer patients
Cancer Therapy - Angiogenesis inhibitor ZD6474 helps control central nervous system tumors in mice
Cancer Therapy - Data advance knowledge in Cancer Therapy research
Cancer Therapy - Reports add new data to Cancer Therapy research
Cardiology - Atherosclerosis prevention in schizophrenics requires targeting multiple risk factors
Cardiology - Neurocardiogenic injury may be due to excess norepinephrine
Cardiology - Sympathetic stimulation can reveal congenital long-QT syndrome
Cardiovascular Research - Aerobic endurance training decreased blood pressure, improved cardiovascular risk factors
Central Nervous System - BDNF may influence the retinal dopaminergic system
Cerebral Palsy - Virus exposure during perinatal period is CP risk factor
Chronic Liver Disease - Study examines new pathways linking cholestatic liver disease to central nervous system changes
Chronic Pain - Positive preliminary results reported from transdur-sufentanil patch study
Chronic Pain - Studies suggest potential for acceptance-based clinical methods for chronic pain management
Clear Cell Sarcoma - Up-regulation of neural markers detected in clear cell sarcoma of the kidney
Clinical Trials - Enrollment completed in phase 2b/3 study of cancer pain drug
Collaborations - AstraZeneca and collaborator announce license, research agreement for Alzheimer compound
Collaborations - Collaboration initiated for new molecular diagnostic assays for rheumatoid arthritis
Complementary & Alternative Medicine - Chiropractic activator methods used in unretractable temporomandibular disorder pain
Developmental Biology - Neurotrophins help maintain the spinal cord motor neurons
Developmental Biology - Removal of apoptotic cells can be lessened in developing neural tubes
Developmental Biology - Slow muscle regulates the pattern of trunk neural crest migration in zebrafish
Diabetes Complications - Microangiopathy may influence normocytic normochromic anemia
Diabetes Therapy - New data illuminates research in Diabetes Therapy
Diagnostics - New findings in the area of diagnostics detailed
Diagnostics - Rapid immunochromatographic assay detects adenovirus from conjunctival swabs
Diagnostics - Reports describe recent advances in diagnostics research
Diet & Nutrition - Diet, but probably not obesity levels, affects hypothalamic energy balance signals
Disease Associations - Increased risk of Alzheimer disease in type 2 diabetes patients is investigated
Drug Development - A modeling study determines the molecular inhibitors of AChE
Drug Development - Approval granted from U.S. FDA for Zonisamide capsules, 25 mg, 50 mg & 100 mg
Drug Development - Investigational new drug application submitted to U.S. FDA for Delta opioid agonist compound
Drug Development - Pivotal phase III trial of drug for Huntington disease commences
Drug Development - Swiss agency approves Erbituxfor for the treatment of head and neck cancer
Drug Development - U.S. FDA grants approval for zonisamide capsules for epilepsy
Dystonia - Reduced fMRI signal reveals dystonic basis for this voice disorder
Facilities - DMI BioSciences is first tenant in new Colorado bioscience park
Finance - Stroke-focused biopharmaceutical company completes $15 million private placement
Finance - Swiss-based pharmaceutical company raises $19 million by further closing B financing round
Fitness & Wellness - Aerobic fitness may increase neurocognitive function in healthy preadolescent children
Fitness & Wellness - Malonyl-CoA hypothalamus levels may be linked to food intake and peripheral energy use
Fungal Infections - Antifungal therapy can prevent relapse in organ transplant recipients
Galantamine - Age-related memory deficits were reversed by galantamine treatment in murine model
Gastroenterology - Notch signal blockade halts pancreatic cancer neurovascular progression
Gene Therapy - Effect of epidermal growth factor receptor inhibitors on gliomas studied
Generic Drugs - U.S. FDA grants approval for generic muscle relaxant baclofen tablet
Glioblastoma - Independent monitoring committee recommends that the PRECISE trial continue as planned
Glioblastomas - Matrix-degrading proteases are expressed in human glioblastomas
Gliomas - PET and SPECT used to image low-grade glioma
Graves Disease - TSAb and TBII measurements are valuable in diagnosis, management of children with Graves disease
Headache & Migraine - Understanding etiology of postpartum headaches may improve therapy, reduce readmissions
Heart Failure - Blood volume rather than BNP may be more accurate guide in CHF
Herpes - BCS appears to be associated with primary HHV-6, but more research is needed
Herpes Simplex Virus - Heparin sulfate isoforms assist HSV-1 entry and spread
Hyperadrenocorticoid - No effect in survival time seen between dogs treated with mitotane or trilostane
Hypertension - Nt-proBNP is inversely related to metabolic CV risk factors and the metabolic syndrome
Imaging - Researchers' findings advance imaging research
Inflammatory Arthritis - T-bet protein plays key role in inflammatory disease
Information Technology - ISPRIT to participate in NCQA's software certification
Insomnia - Diagnosis and treatment of insomnia of interest to general practitioners
Leishmaniasis - Sitamaquine is efficacious for visceral leishmaniasis treatment in Kenya
Leukemia - Adolescent survivors of acute lymphoblastic leukemia suffer psychological and physical pain
Lissencephaly - Mouse model created to study genetic brain syndrome
Macroadenomas - Strategies for management of invasive macroadenomas are needed
Marketing - Biotech company engages Isserman Consulting for public awareness and investor relations
Meningioma - Leakage volume and permeability measured with dynamic contrast-enhanced MRI
Mental Health - Negative affects of sleep shortage on health reported in Harvard newsletter
Mental Health - Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells
Mergers & Acquisitions - BladderScan maker acquires GlideScope manufacturer
Mergers & Acquisitions - Extensive gene therapy assets acquired
Multiple Sclerosis - Blocking leptin helps halt, heal MS
Multiple Sclerosis - Regulatory T cells relieve the suppressed immune response in multiple sclerosis
Muscular Dystrophy - Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, study finds
Mycobacterium Tuberculosis - Dexamethasone suppresses cytokines/chemokines induced after MTB microglia infection
Nanotechnology - Dendrimers with high drug payload can improve drug efficacy
Neurology - Physiological and pathological changes in glucose regulate brain Akt-GSK3
Neurology - Preformed amyloid seeds accelerated alpha-synuclein amyloid fibril formation
Neurology - Radiosurgery used to treat primary central nervous system lymphoma of brain stem
Neurology - Review investigates the influence of leptin on hippocampal synaptic plasticity
Neuropathic Pain - Endothelin A receptor is a potential therapeutic target for neuropathic pain
Neuroscience - DCDC2 is associated with reading disability and modulates neuronal development in the brain
Neuroscience - Findings advance knowledge in neuroscience research
Neuroscience - Glutamatergic receptor upregulation may mediate persistent drug intake, craving in cocaine addiction
Neuroscience - Hippocampal plasticity-related proteins are regulated strain-dependently
Neuroscience - Hyperphosphorylation of intermediate filament proteins may be involved in neuropathology
Neuroscience - Lipopolysaccharide post-conditioning reduces brain and spinal cord inflammation
Neuroscience - Neuronal differentiation is unaffected by the reduction of neuropathy target esterase
Neuroscience - Recent studies add new data to neuroscience research
Neuroscience - Researchers describe findings in neuroscience studies
Neuroscience - Restraint stress alters opiate withdrawal
Neuroscience - Serotonin transporter gene polymorphisms influence cognitive abilities
Neuroscience - Sleep disorders affect growing baby boomer population
Neuroscience - Studies show brain endocannabinoid protects neurons against inflammation after injury
Non-Hodgkin Lymphoma - Positive interim results reported from phase I trial for CB3304 (noscapine) in non-Hodgkin lymphoma
Obesity Therapy - Polymorphisms in SLC6A2 and GRIN1 affect weight loss response of GW320659 in obese subjects
Orthopedics - Surgical techniques ease wrist pain due to arthritis or carpal tunnel syndrome
Osteoporosis - U.S. FDA approves osteoporosis indication for once-a-week hormone therapy patch
Otitis Media - Complications of otitis media in adults have considerable morbidity and require early detection
Pain Management - Pain treatment analyzed among patients with incurable malignant tumors
Pain Management - Pharma company files complete response to U.S. FDA on application for oxymorphone ER
Pain Management - Pregabalin or morphine and gabapentin offer treatment options for neuropathic pain
Pain Management - U.S. FDA accepts investigational new drug application for Sativex
Palliative Care - Use of spirituality, psychotherapy and music in palliative cancer care examined
Parkinson Disease - Changes induced by levodopa and subthalamic nucleus stimulation on Parkinsonian speech
Parkinson Disease - Embryonic expression of alcohol and aldehyde dehydrogenases contributes to Parkinson disease
Parkinson Disease - GDNF protects complex motor functions in Parkinsonism
Parkinson Disease - Parkinson disease-associated mutations augment kinase activity
Peripheral Artery Disease - Walking three times weekly slows decline from vascular disease
Personnel - Jose L. Rodriguez named vice president of business development of specialty pharma
Personnel - Marie-Helene Plais-Cotrel named to board of directors of medical devices company
Pharmacogenetics - Researchers call for individualized approach to medicine and drug testing
Polyomavirus JC - Polyomavirus JC-specific cytotoxic T cells are present in the CNS of PML patients
Product Licensing - Global licensing deal signed for pain drug candidate
Product Licensing - Pharma company signs license agreement for European rights to Rapinyl
Proteomics - PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with SSTR5
Proteomics - Study reveals that ALS and Parkinson disease distinguishing protein biomarkers differ
Seizure Disorders - Alexithymia may be beneficial to patients with nonepileptic seizures
Seizure Disorders - Nasal midazolam treatment after drug-induced seizure led to seizure cessation in rats
Stem Cell Research - Adult hippocampal progenitor is neurogenic but not a stem cell
Stem Cell Research - Astrocyte differentiation selectively upregulates CCL2/MCP-1 in brain-derived stem cells
Stem Cell Research - Cell microarray screens feeder cells for embryonic stem cells differentiation
Stem Cell Research - Data show hair follicle stem cells rival embryonic stem cells in regenerative potential
Stem Cell Research - MEK-C/EBP pathway activation in cortical precursors biases them to become neurons
Stem Cell Research - PBK/TOPK is a marker for transiently amplifying neural progenitors in subependymal zone
Stem Cell Transplantation - Transplanted HSCs and BM stromal cells promote recovery in injured spinal cord
Stroke - Combination of hypertension and type 2 diabetes drastically increase stroke risk
Stroke - Comprehensive rehabilitation results in functional gains in posterior cerebral artery stroke
Stroke - Conversion of ischemic brain tissue into infarction increases with age
Stroke - Particulate air pollution may raise stroke risk
Stroke - Recombinant factor VIIa is potentially useful for intracerebral hemorrhage
Stroke - Researchers' findings advance stroke research
Surgical Technology - ActiPatch shipped for plastic surgery applications
Surgical Technology - Studies describe new findings in Surgical Technology research
Sweat Production - Impairment in sweat production seen in diabetics may be due to heat sensitivity mechanism
Systemic Lupus Erythematosus - Anti-SAP antibody titers decreased after treatment and correlated with clinical improvement
Transplantation Biology - Cytolytic effector pathways are up-regulated in rejected renal allograft tissue
Varicella-Zoster Virus - Small plaque varicella-zoster virus mutants are defective in viral gene expression
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