Pain and Central Nervous System Week

Alzheimer Disease - Link discovered between long-term depression and changes in the AD brain

Central Nervous System - Glutamate receptor agonist may be an effective tool for investigating stress-related CNS disorders

Pain Management - Brain activity readings show women with low estrogen levels are more sensitive to pain

Rett Syndrome - Brain derived neurotrophic factor alleviates symptoms of Rett syndrome in mouse model

Schizophrenia - Nicotine downregulates dopamine D₂ receptor availability in antipsychotic drug treatment

Addiction Medicine - New findings in addiction medicine described

Adverse Drug Reactions - Anticholinergic drugs linked to mental impairment in elderly people

Adverse Drug Reactions - Ototoxicity in children receiving platinum chemotherapy may impact academic and social development

Alcohol Use - Fourteen or more alcoholic drinks per week are associated with lowest CAD risk

Allergy & Immunology - U.S. FDA approves Clarinex-D 12 Hour

Alzheimer Disease - Apolipoprotein E4 is a potential therapeutic target for Alzheimer disease

Alzheimer Disease - Genetic factors important in development and timing of Alzheimer disease

Alzheimer Disease - Genomic regulation in microglia perturbs genes relevant to Alzheimer disease

Amyotrophic Lateral Sclerosis - Low vascular endothelial growth factor expression may encourage neurodegeneration in mice

Anesthesia - Fentanyl reduced emergent agitation for developmentally disabled dental patients

Anesthesia - TransDermal Delivery System beta suitable for local anesthesia in venipuncture

Anesthesia - Using intrathecal morphine with remifentanil enhances post-OPCAB analgesia

Angina - U.S. FDA approves Ranexa

Angiology - Adverse CV influence of low testosterone may be mediated via vascular structure, function

Angiology - Nebivolol is novel beta-blocker with endothelium-derived NO enhancement benefit

Anti-Inflammatories - COX mechanisms play a role in maintaining pain hypersensitivity

Anti-Inflammatories - Nitric oxide mediates the anti-inflammatory activity of extracorporeal shock waves

Anxiety - Anxiety and depression were associated with impaired work performance and safety

Anxiety - Depression severity unrelated to psychic and somatic anxiety components

Apoptosis - P73 regulation may have implications for neurological disease treatment

Apoptosis - p53 deficiency rescues apoptosis and differentiation of multiple cell types

Astrocytic Gliomas - TSC-22 protein expression is decreased in astrocytic gliomas

Attention Deficit Hyperactivity Disorder - Drugmaker provides update on regulatory status of Sparlon

Attention Deficit Hyperactivity Disorder - Novel assay detects therapeutic and illicit amphetamine enantiomers in hair and blood

Behavior Disorders - Comprehensive Behavioral Care expands services to Maryland and Washington, DC

Behavioral Medicine - Endocannabinoids and leptin may modulate hypothalamic circuits involved in feeding behavior

Bipolar Disorder - Rapid mood switching and suicidality studied in familial bipolar disorder

Brain Cancer - Molecularly targeted therapy for pediatric brain tumors discussed

Breast Cancer - Breast cancer marker receives diagnostic and therapeutic patent approval

Business & Finance - Company reports Q4 revenue of $132.7M, discusses remarketing of Tysabri

Business & Finance - Maker of blood oxygen monitoring system files registration for public equity offering

Business Update - CRO retains The Equity Group to provide investor relations services

Cancer Diagnostics - Genetic testing used to diagnose pheochromocytoma or functional paraganglioma

Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge

Cardiology - Apex-to-base relaxation gradients may facilitate restoration of LV cavity in diastole

Cardiology - Beta-blockers remain a cornerstone of cardiovascular therapy

Cardiology - New findings in the area of cardiology detailed

Cardiology - Reports add new data to cardiology research

Cardiology - The role of GH in cardiovascular risk in aging and obese is reviewed

Cardiovascular Disease - Socio-economically patterned access to medical care may be factor in SES and CVD relation

Cardiovascular Disease - Strategic sampling of NT-pro BNP concentration could inform management of ACS patients

Charcot-Marie-Tooth Disease - Gene mutation discovered that causes rare form of inherited nerve disorder

Childhood Cancer - Long-term outcomes of adult survivors of childhood cancer reviewed

Chronic Obstructive Pulmonary Disease - Emotional burden of COPD may make patients reluctant to seek treatment, survey shows

Cirrhosis - Bilirubin might be a marker for sleep apnea syndrome and early stage cirrhosis

Complementary & Alternative Medicine - Laserpitin lowers hepatic triglyceride content in stroke-prone spontaneously hypertensive rats

Complementary & Alternative Medicine - Mindfulness-based stress reduction better for mood improvement, massage better for pain

Complementary & Alternative Medicine - Vitaline Smart Q10 shown to be safe and well-tolerated

Contracts - Proteomics company retains Glocap Advisors as financial advisory firm

Depression - Findings advance knowledge in depression research

Depression - Individual illness characteristics are predictive of treatment expectations

Developmental Biology - Crescent modulates Wnt signaling in early Xenopus embryogenesis

Diabetes Complications - Review discusses the impact of diabetes on cognition

Diabetes Complications - Taller patients with diabetes have higher risk of foot or leg amputation

Diabetes Diagnostics - New imaging technology detects subtle changes in brains of type 1 diabetics, study shows

Diabetes Pathogenesis - Neuronal insulin signal transduction mechanisms may be disrupted in diabetes phenotypes

Diabetes Pathogenesis - Overexpression of the coactivator Bridge-1 results in insulin deficiency and diabetes

Diabetes Pathogenesis - Semicarbazide-sensitive benzylamine oxidase expression controls methylamine hypophagia

Diabetes Therapy -  Shakuyakukanzoto effect in diabetics may rely on descending noradrenergic neuron activation

Diabetes Therapy - MIRE did not improve sensation in diabetes related peripheral neuropathy

Diagnostics - ECG and natriuretic peptide tests have comparable accuracy in LVSD diagnosis

Diagnostics - Equipment and environment have little impact on speech-in-noise audiometry results

Diagnostics - Gastroesophageal reflux disease is most common esophageal disease associated with noncardiac chest pain

Diagnostics - Parathyroid hormone testing predicts post-thyroidectomy hypocalcemia

Diagnostics - Subset of patients may benefit from inclusion of bone biopsy into diagnostic procedure

Diagnostics - Utility of three diagnostic tests for acute pancreatitis compared

Diet & Nutrition - Older adults are vulnerable to adverse effects of dietary fat and to various forms of dementia

Disease Associations - Increased pulse wave velocity, diastolic BP are demonstrated in subclinical hypothyroidism

Disease Associations - Population-based study finds no link between prior myocardial infarction and dementia

Drug Delivery - Age and tumor type influence transdermal fentanyl absorption in cancer pain patients

Drug Delivery - Subcutaneous microsphere injection effective for sustained clonazepam release

Drug Development - Data on Phenserine and Posiphen for Alzheimer disease to be presented in Geneva

Drug Development - Icon retained for phase II/III trial for MBP8298 to treat multiple sclerosis

Drug Development - Lundbeck, collaborator to discover allosteric modulators of G-protein coupled receptors

Drug Development - NDA submitted to U.S. FDA for involuntary emotional expression disorder therapy

Drug Development - New subsidiary to accelerate RNAi therapeutics programs

Drug Development - Pharmaceutical firm focused on diseases of aging and diabetes provides clinical pipeline update

Drug Development - Positive results reported in phase III study of Entereg in postoperative ileus

Drug Development - Prescription product with nutritional components for osteoarthritis introduced nationally

Drug Development - U.S. FDA requests additional data for Delta opioid agonist; application on hold

Endocrinology - Amygdala plays a role in regulating emotionality through glucocorticoids

Endocrinology - Effects of increased plasma ghrelin levels on metabolism and endocrine system are studied

Finance - Alzheimer's Foundation seeks grant applications for innovative care

Finance - Connecticut to receive mental health state incentive grant of $13.6 million over 5 years

Finance - Medical device company reports total revenues of $10.3 million for the fourth quarter 2005

Finance - Neurobiological Technologies receives $1.4 million quarterly royalty payment related to Memantine

Finance - Pharma company begins trading under symbol NHPI, announces $4.35 million private placement

Finance - Q4 2005 sales of Copaxone up 24% to $323 million, annual sales up 26%, company reports

Finance - SBIR grant to be used for study of drug for stroke patients

Finance - Somanetics reports record net revenues for FY 2005

Fitness & Wellness - DIO is linked to lower spontaneous physical activity and nonexercise activity thermogenesis

Fitness & Wellness - High-dose growth hormone increases glucose production and uptake

Gastrinomas - Gastrinomas associated with MEN-1 syndrome

Gene Therapy - BACE1 deletion rescues temporal memory deficits in Alzheimer mouse models

Gene Therapy - STAT3 activation is differentially regulated in squamous cell carcinomas

Generic Drugs - Pharma company announces final U.S. FDA approval for alprazolam extended-release tablets

Genetics & Genomics - MT-II brain gene expression is primary candidate for ethanol preference control in mice

Genetics & Genomics - Research tools company launches program enabling institution-wide access to shRNAmir libraries

Germ-Cell Tumors - Follow-up advised for 2 years after first-line treatment of germ-cell tumors

Glioma - Dihydroartemisinin enhanced radiosensitivity of human glioma cells

HIV/AIDS Behavioral Medicine - Alcohol consumption linked to high-risk sexual behavior in Gauteng province

HIV/AIDS Behavioral Medicine - Methadone maintenance therapy reduces heroin use and HIV risk behavior

HIV/AIDS Drug Delivery - HIV Tat fusion proteins reduce brain injury following ischemic stroke

HIV/AIDS HAART - Psychological distress and pain not associated with episodes of detectable viremia

HIV/AIDS Palliative Care - HIV/AIDS patients report significant physical and psychological symptoms despite treatment