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Pain and Central Nervous System Week

Susan Hasty, Publisher

Table of Contents . . . April 3rd, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pain and Central Nervous System Week | Other Publications

Anesthesia - Angioplasty of lower limb is facilitated by use of regional nerve blockade

Brain Disorders - Cell-death mechanism tied to developmental, degenerative brain disorders

Diagnostics - Ergonovine test can diagnose vasospastic angina

Migraine Headache - New analysis shows many migraine sufferers are wrongly prescribed narcotics and opioids for pain

Spinal Cord Injury - Two therapies show results for some with partial spinal cord injury

Adverse Drug Reaction - Alzheimer disease-related cognitive impairment delayed by cholinesterase inhibitors

Adverse Drug Reaction - Incidence of ischemic stroke post-chemotherapy reviewed

Adverse Drug Reaction - U.S. FDA web site warns of risk of cardiovascular adverse reactions from methylphenidate

Allergy & Immunology - Modified Langerhans-type dendritic cells express full-length stimulatory antigen

Alzheimer Disease - Drug company reviews studies on potential of statin drugs to treat Alzheimer disease

Alzheimer Disease - New findings in the area of Alzheimer disease detailed

Anesthesia - Enhanced efficacy of propofol during cardiopulmonary bypass may be due to reduced plasma binding

Angiology - Findings in angiology provide new insights

Angiology - Lacunar infarction patients show no added impairment of cerebral endothelial function

Angiology - New data illuminates research in angiology

Angiology - Shamblin classification requires modification to reflect morbidity of carotid body tumors

Asthma - Asthma exacerbations not much lower over time despite treatment options, study shows

Astrocytomas - Speech deficits indicated as sequelae of transient cerebellar mutism

Awards - American Psychological Association gives healthy workplace awards to six organizations

Awards - U.S. Senator Gordon Smith recognized by APA for dedication to mental health issues

Axonal Injury - Traumatic axonal injury reviewed

Bipolar Disorder - Bipolar disorder treatment is modified by a functional polymorphism

Bipolar Disorder - Bipolar mania may be linked to previous antipsychotic treatment

Bovine Spongiform Encephalopathy - Bovine spongiform encephalopathy infection underestimated by passive surveillance system

Brain Cancer - Inversion recovery MR sequences used to assist in specifying surgical boundaries

Brain Cancer - Neurologists recommend MRIs for early detection of brain metastases in lung and breast cancer

Breast Cancer - Fatigue in long-term breast carcinoma survivors investigated

Cancer Gene Therapy - Triple anti-tumor gene transfer inhibits growth in glioblastoma cells

Cardiology - New findings in the area of cardiology described

Cardiology - New findings in the area of cardiology detailed

Cardiology - Reduced forearm alpha1 -adrenergic vasoconstriction is associated with heart rate fluctuations

Cardiology - Reports add new data to cardiology research

Cardiology - Reports describe recent advances in cardiology research

Cardiology - Researchers detail new studies and findings in the area of cardiology

Cardiovascular Research - Lipid embolization after cardiac surgery is a phenomenon not restricted to brain

Central Nervous System Tumors - Outcomes of central nervous system tumors in pediatric patients reviewed

Cerebrovascular Diseases - Patients with cerebral arteriovenous malformations have high VEGF levels

Clinical Trials - Acorda Therapeutics completes enrollment in Fampridine-SR trial in multiple sclerosis

Clinical Trials - Adult ADHD study with CX717 shows positive results, reports Cortex

Clinical Trials - C1-inhibitor concentrate relieves abdominal pain in angioedema patients, study shows

Clinical Trials - Corgentech ALGRX 4975 trial meets primary endpoint of decreased pain for tendonitis patients

Clinical Trials - One-year study shows anticholinergic medication lowers exacerbations in patients with COPD

Clinical Trials - Stanford University doctors discuss flaw in clinical trial of multiple sclerosis drug

Clinical Trials - Stem Cell Therapeutics reports interim preclinical data on therapy for treatment of stroke

Clinical Trials - Superior pain relief reported in trial of intranasal morphine in postsurgical pain

Clinical Trials - Trial data show entecavir more beneficial than lamivudine in treating hepatitis B patients

Clinical Trials - Two-year phase 3 trial results and safety evaluation of Tysabri in relapsing MS published

Clinical Trials - UCB submits biologics license application to U.S. FDA for new treatment in Crohn disease

Clinical Trials - WEX Pharmaceuticals announces committee recommendation to halt Tectin phase 2b/3 trial

Complementary & Alternative Medicine - BioAstin significantly reduces systemic inflammation in humans, Cyanotech study shows

Coronary Artery Bypass - Studies add new findings to coronary artery bypass body of knowledge

Dementia - Dementia patients use art therapy to reduce feelings of isolation

Depression - Depression model leaves mice with molecular scar

Depression - Depression needs to be diagnosed and treated in persons at risk for myocardial infarction

Depression - In depressed patients, brain white-matter hyperintensities correlated with cardiovascular risk

Depression - Major depression can be ameliorated through transcranial magnetic stimulation

Depression - Repetitive transcranial magnetic stimulation efficacy evaluated in unipolar depression

Depression - Scientists gain new understanding of age-related depression and dementia

Depression Therapy - Antidepressant alterations in the mesocorticolimbic brain may improve behavior

Depression Therapy - Antidepressant therapy can counteract the degenerative processes associated with major depression

Dermatology - Atopic dermatitis-like model in mice determines parasitism of mites, not allergies, are the cause

Dermatology - New atopic dermatitis therapy used with emollient delays onset of flares, study shows

Desmoplastic Fibromas - Desmoplastic fibroma of the skull described

Diabetes Complications - ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy

Diabetes Pathogenesis - New findings in diabetes pathogenesis described

Diabetes Therapy - Quinapril or losartan improved DAN and LVDD in asymptomatic patients with diabetes mellitus

Diagnostics - Signet, Bayer sign agreement to do research on urinary trypsin inhibitor immunoassays

Diagnostics - West Nile Virus may cause infectious cerebrospinal fluid pleocytosis

Disease Associations - Researchers' findings advance disease associations research

Drug Abuse - Safeway adds restrictions for pseudoephedrine product sales to curtail meth abuse

Drug Abuse - Washington state to jointly evaluate Hythiam's protocols for meth and cocaine dependence

Drug Development - A neural network can determine cytotoxic compounds

Drug Development - AC Immune identifies lead compounds for Alzheimer disease treatment

Drug Development - AlphaRx's joint venture firm receives marketing approval for Flexogan in Hong Kong

Drug Development - Avidex completes two phase I studies for RhuDex

Drug Development - BioMS Medical's MBP8298 shows 5-year delay of multiple sclerosis disease progression

Drug Safety - Acetaminophen-related liver failure on the rise in the U.S.

Drug Toxicity - Drug toxicity may be higher in neonates and young children due to an underdeveloped P-glycoprotein

Dystonia - Focal dystonia benefits from treatment with botulinum toxin

Environmental Health - Cancer incidence linked to air emissions of volatile organic compounds

Environmental Health - Researchers report details of new studies and findings in the area of environmental health

Finance - CytRx enters into agreements for $13.4 million private placement

Finance - EntreMed reports fourth quarter and year-end 2005 financial results

Finance - Galapagos announces revenue, net loss increases in 2005

Finance - Medivation common stock approved for listing on the American Stock Exchange

Finance - Millennium achieves $10 million milestone payment from Johnson & Johnson for Velcade for Injection

Finance - Myogen reports net loss of $63 million or $1.68 per share for 2005

Finance - NMT Medical announces fourth quarter revenues increased 25% to approximately $6.3 million

Finance - Neurogen Corporation announces $10.6 million net loss for the fourth quarter of 2005

Finance - Neuromed raises US$25 million, completing fourth-round private equity financing

Finance - Noven announces net income of $10 million for 2005

Finance - Penwest reports fourth quarter revenues of $931,000

Generic Drugs - U.S. FDA grants tentative approval to generic form of anticonvulsant Topamax 50 mg tablets

Genetics & Genomics - Neural precursor cell differentiation and migration properties regulated by Emx2

Genetics & Genomics - RNA splicing and chromatin remodeling prominent processes for adult neurogenesis

Genetics & Genomics - Researchers' findings advance genetics & genomics research

Gliomas - Efficacy of treating malignant gliomas with sulfasalazine examined

Gliomas - Nm23 expression may suppress glioma migration and invasion

Gliomas - Prognosis of glioma linked to increased expression of CCAAT/enhancer binding protein 6

Gliomas - Recent findings in gliomas described

HIV/AIDS Pathogenesis - HIV infection in astrocytes altered by cytokine priming

HIV/AIDS-Associated Dementia - AIDS-associated neuronal loss may be due to neuronal apoptosis

Hand Preference - The evolution of handedness compared in modern and medieval times

Healthcare Costs - Hospital resources are consumed in treating complications associated with PCI

Hypertension - Recent findings in hypertension described

Imaging - After transient cerebral ischemia, T1-weighted MR images may represent irreversible tissue injury

Insomnia - Insomnia treatment by ramelteon had mild or moderate adverse reactions

Ischemia - Recent studies add new data to ischemia research

Legal Issues - Shire sues Teva regarding ANDA for generic versions of ADHD medicine in six doses

Lipid Research - Titan initiates phase 2 study of DITPA in treatment of elevated cholesterol levels

Market Analysis - Ortho-McNeil Neurologics-sponsored analysis identifies top 10 migraine hot spots in U.S.

Medical Devices - Findings in medical devices provide new insights

Medical Devices - Micrus Endovascular receives approval to sell neurovascular stent in Europe

Medulloblastomas - Array comparative genomic hybridization analysis of medulloblastomas performed

Medulloblastomas - Childhood central nervous system tumors were not linked to expression of Gas7

Medulloblastomas - Medulloblastoma treated by histone deacetylase inhibitors

Meningiomas - Malignant meningioma detected as second malignancy after therapy for leukemia

Mergers & Acquisitions - Cardium acquires InnerCool Therapies, a provider of therapeutic hypothermia systems

Mergers & Acquisitions - Covalent enters into combination agreement with Remedium Oy

Multiple Sclerosis - HLA typing of MS patients may help identify patients for alternative therapies

Muscle Spasms - Botulinum toxin-A injections for spastic toe clawing reduces spasticity

Myeloma - Myeloma study using thalidomide shows improved remission rates

Natural Products -  Echium amoenum may have some antidepressant activity

Neuroblastomas - Biology of neuroblastomas detected by mass screening was studied

Neuroblastomas - Outcome of neuroblastoma patients determined by metastatic recurrence, not extent of resection

Neurogenesis - Neurogenesis occurs in neuroinflammatory lesions in the adult spinal cord

Neurology - Brain structure is influenced by hyperglycemia and hypoglycemia in type 1 diabetes

Neurology - Diabetes patients' cognitive impairments arise from microvascular changes

Neurology - Metabotropic receptors are coupled to cGMP levels in certain neural cell types

Neurology - Rosuvastatin improves cerebrovascular function by inhibiting NAD(P)H oxidase

Neuroscience - Amarin reports Miraxion improves stress hormone transport

Neuroscience - MDMA maintains antiaggressive effects on behavior 3 weeks post administration

Neuroscience - Sema3A is neuroprotective of injury mediated by activated microglia

Neuroscience - Sympathetic nervous dysfunction involving sinus node is present in de novo Parkinson disease

Neurotology - Preserving hearing with ear tumor removal

Nicotine Addiction - A nicotine addiction neurocomputational hypothesis has been developed

Obstetrics - Mission Pharmacal Company introduces new Citracal prenatal + DHA as prenatal vitamin

Oncology - Brain tumor angiogenesis is regulated by NG2

Ophthalmology - Eyes with retinal ischemia improve after receiving XIAP gene therapy

Orthopedics - U.S. FDA approves label change to include physician dosing option for joint fluid therapy

Osteoarthritis - Nuvo announces Pennsaid data reviewing four trials was published in the Journal of Rheumatology

Osteoporosis - Reports advance knowledge in osteoporosis research

Pain & Obesity - Obese people reported to be more sensitive to pain

Pain Management - Placebo treatment for back pain produced comparable increases in relief to clinical and experimental interventions

Pain Management - SpineMED decompression table rehydrates spinal discs to relieve pain

Parkinson Disease - Parkinson disease behavioral recovery induced by stem cell-derived neurons

Parkinson Disease - Parkinsonian symptoms may involve mitonchondrial ATP-sensitive potassium channels

Parkinson Disease - Patients with Parkinson disease require careful dopaminergic treatment evaluation

Personnel - Genesis Bioventures announces addition of international scientist to scientific advisory board

Personnel - Gentiva announces new executive appointments and promotion of CFO

Personnel - Myriad Pharmaceuticals names Jose Fojas as vice president of marketing

Pharmaceutical Research - Phase III drugs slated to add additional $30 billion in revenues by 2010

Physiology - Receptor overexpression exaggerates locomotor and hypothermic response

Prostate Cancer - Proteome Systems Limited announces 60.6% increase in revenue for the half year

Proteomics - Neonatal PBDE-99 exposure could contribute to persistent neurotoxic effects

Proteomics - Reports describe recent advances in proteomics research

Radiation Therapy - Radiation therapy is associated with significant loss of bone mineral

Schizophrenia - Schizophrenia potential therapeutic target identified

Schizophrenia - Schizophrenia symptoms did not improve when risperidone was added to clozapine

Scoliosis - Adolescent scoliosis patients treated surgically are at risk for distal junctional kyphosis

Sleep Apnea - Sleep apnea syndrome patients had a high prevalence of high serum creatine phosphokinase levels

Spinal Cord Injury - Neuronal response in spinal cord injury may involve IL-6 stimulation of the Janus kinase pathway

Spondylolisthesis - Fusion of the health L4/5 segment can be avoided in developmental spondylolisthesis

Stem Cell Research - Astrocytes can induce hematopoietic stem cells to differentiate into neural cells

Stem Cell Research - Embryonic stem-like cells from canine blastocytes isolated and characterized

Stem Cell Research - Intrinsic determinants of midbrain dopamine neurons identified

Stem Cell Research - Neural stem cell maintenance and gliogenesis requires brahma-related gene 1

Stem Cell Research - Neuronal differentiation decreased by ethanol in a dose-dependent manner

Stem Cell Research - Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo

Stem Cell Research - Oregon IRB approves phase 1 trial using purified human neural stem cells in Batten disease

Stem Cell Research - Stem cell attraction to their niche related by sympathetic nervous system

Stem Cell Therapy - Neural progenitor transplant restores metabolic deficits in Huntington disease model

Stem Cell Transplantation - Researchers' data advance stem cell transplantation research

Surgical Technology - Aortic aneurysm repair with stented elephant trunk is linked to increased spinal cord injury risk

Surgical Technology - Endovascular stent-graft placement in aortic dissection compares favorably with surgical treatment

Surgical Technology - Freehand two-step CT-guided brain tumor biopsy is safe and effective

Temporomandibular Disorders - Temporomandibular disorder symptoms can be relieved by cognitive behavior therapy

Vagus Nerve Stimulation - Vagus nerve stimulation does not significantly influence body weight in epilepsy patients

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