Susan Hasty, Publisher
Table of Contents . . . April 3rd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Anesthesia - Angioplasty of lower limb is facilitated by use of regional nerve blockade
Brain Disorders - Cell-death mechanism tied to developmental, degenerative brain disorders
Diagnostics - Ergonovine test can diagnose vasospastic angina
Migraine Headache - New analysis shows many migraine sufferers are wrongly prescribed narcotics and opioids for pain
Spinal Cord Injury - Two therapies show results for some with partial spinal cord injury
Adverse Drug Reaction - Alzheimer disease-related cognitive impairment delayed by cholinesterase inhibitors
Adverse Drug Reaction - Incidence of ischemic stroke post-chemotherapy reviewed
Adverse Drug Reaction - U.S. FDA web site warns of risk of cardiovascular adverse reactions from methylphenidate
Allergy & Immunology - Modified Langerhans-type dendritic cells express full-length stimulatory antigen
Alzheimer Disease - Drug company reviews studies on potential of statin drugs to treat Alzheimer disease
Alzheimer Disease - New findings in the area of Alzheimer disease detailed
Anesthesia - Enhanced efficacy of propofol during cardiopulmonary bypass may be due to reduced plasma binding
Angiology - Findings in angiology provide new insights
Angiology - Lacunar infarction patients show no added impairment of cerebral endothelial function
Angiology - New data illuminates research in angiology
Angiology - Shamblin classification requires modification to reflect morbidity of carotid body tumors
Asthma - Asthma exacerbations not much lower over time despite treatment options, study shows
Astrocytomas - Speech deficits indicated as sequelae of transient cerebellar mutism
Awards - American Psychological Association gives healthy workplace awards to six organizations
Awards - U.S. Senator Gordon Smith recognized by APA for dedication to mental health issues
Axonal Injury - Traumatic axonal injury reviewed
Bipolar Disorder - Bipolar disorder treatment is modified by a functional polymorphism
Bipolar Disorder - Bipolar mania may be linked to previous antipsychotic treatment
Bovine Spongiform Encephalopathy - Bovine spongiform encephalopathy infection underestimated by passive surveillance system
Brain Cancer - Inversion recovery MR sequences used to assist in specifying surgical boundaries
Brain Cancer - Neurologists recommend MRIs for early detection of brain metastases in lung and breast cancer
Breast Cancer - Fatigue in long-term breast carcinoma survivors investigated
Cancer Gene Therapy - Triple anti-tumor gene transfer inhibits growth in glioblastoma cells
Cardiology - New findings in the area of cardiology described
Cardiology - New findings in the area of cardiology detailed
Cardiology - Reduced forearm alpha1 -adrenergic vasoconstriction is associated with heart rate fluctuations
Cardiology - Reports add new data to cardiology research
Cardiology - Reports describe recent advances in cardiology research
Cardiology - Researchers detail new studies and findings in the area of cardiology
Cardiovascular Research - Lipid embolization after cardiac surgery is a phenomenon not restricted to brain
Central Nervous System Tumors - Outcomes of central nervous system tumors in pediatric patients reviewed
Cerebrovascular Diseases - Patients with cerebral arteriovenous malformations have high VEGF levels
Clinical Trials - Acorda Therapeutics completes enrollment in Fampridine-SR trial in multiple sclerosis
Clinical Trials - Adult ADHD study with CX717 shows positive results, reports Cortex
Clinical Trials - C1-inhibitor concentrate relieves abdominal pain in angioedema patients, study shows
Clinical Trials - Corgentech ALGRX 4975 trial meets primary endpoint of decreased pain for tendonitis patients
Clinical Trials - One-year study shows anticholinergic medication lowers exacerbations in patients with COPD
Clinical Trials - Stanford University doctors discuss flaw in clinical trial of multiple sclerosis drug
Clinical Trials - Stem Cell Therapeutics reports interim preclinical data on therapy for treatment of stroke
Clinical Trials - Superior pain relief reported in trial of intranasal morphine in postsurgical pain
Clinical Trials - Trial data show entecavir more beneficial than lamivudine in treating hepatitis B patients
Clinical Trials - Two-year phase 3 trial results and safety evaluation of Tysabri in relapsing MS published
Clinical Trials - UCB submits biologics license application to U.S. FDA for new treatment in Crohn disease
Clinical Trials - WEX Pharmaceuticals announces committee recommendation to halt Tectin phase 2b/3 trial
Complementary & Alternative Medicine - BioAstin significantly reduces systemic inflammation in humans, Cyanotech study shows
Coronary Artery Bypass - Studies add new findings to coronary artery bypass body of knowledge
Dementia - Dementia patients use art therapy to reduce feelings of isolation
Depression - Depression model leaves mice with molecular scar
Depression - Depression needs to be diagnosed and treated in persons at risk for myocardial infarction
Depression - In depressed patients, brain white-matter hyperintensities correlated with cardiovascular risk
Depression - Major depression can be ameliorated through transcranial magnetic stimulation
Depression - Repetitive transcranial magnetic stimulation efficacy evaluated in unipolar depression
Depression - Scientists gain new understanding of age-related depression and dementia
Depression Therapy - Antidepressant alterations in the mesocorticolimbic brain may improve behavior
Depression Therapy - Antidepressant therapy can counteract the degenerative processes associated with major depression
Dermatology - Atopic dermatitis-like model in mice determines parasitism of mites, not allergies, are the cause
Dermatology - New atopic dermatitis therapy used with emollient delays onset of flares, study shows
Desmoplastic Fibromas - Desmoplastic fibroma of the skull described
Diabetes Complications - ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy
Diabetes Pathogenesis - New findings in diabetes pathogenesis described
Diabetes Therapy - Quinapril or losartan improved DAN and LVDD in asymptomatic patients with diabetes mellitus
Diagnostics - Signet, Bayer sign agreement to do research on urinary trypsin inhibitor immunoassays
Diagnostics - West Nile Virus may cause infectious cerebrospinal fluid pleocytosis
Disease Associations - Researchers' findings advance disease associations research
Drug Abuse - Safeway adds restrictions for pseudoephedrine product sales to curtail meth abuse
Drug Abuse - Washington state to jointly evaluate Hythiam's protocols for meth and cocaine dependence
Drug Development - A neural network can determine cytotoxic compounds
Drug Development - AC Immune identifies lead compounds for Alzheimer disease treatment
Drug Development - AlphaRx's joint venture firm receives marketing approval for Flexogan in Hong Kong
Drug Development - Avidex completes two phase I studies for RhuDex
Drug Development - BioMS Medical's MBP8298 shows 5-year delay of multiple sclerosis disease progression
Drug Safety - Acetaminophen-related liver failure on the rise in the U.S.
Drug Toxicity - Drug toxicity may be higher in neonates and young children due to an underdeveloped P-glycoprotein
Dystonia - Focal dystonia benefits from treatment with botulinum toxin
Environmental Health - Cancer incidence linked to air emissions of volatile organic compounds
Environmental Health - Researchers report details of new studies and findings in the area of environmental health
Finance - CytRx enters into agreements for $13.4 million private placement
Finance - EntreMed reports fourth quarter and year-end 2005 financial results
Finance - Galapagos announces revenue, net loss increases in 2005
Finance - Medivation common stock approved for listing on the American Stock Exchange
Finance - Millennium achieves $10 million milestone payment from Johnson & Johnson for Velcade for Injection
Finance - Myogen reports net loss of $63 million or $1.68 per share for 2005
Finance - NMT Medical announces fourth quarter revenues increased 25% to approximately $6.3 million
Finance - Neurogen Corporation announces $10.6 million net loss for the fourth quarter of 2005
Finance - Neuromed raises US$25 million, completing fourth-round private equity financing
Finance - Noven announces net income of $10 million for 2005
Finance - Penwest reports fourth quarter revenues of $931,000
Generic Drugs - U.S. FDA grants tentative approval to generic form of anticonvulsant Topamax 50 mg tablets
Genetics & Genomics - Neural precursor cell differentiation and migration properties regulated by Emx2
Genetics & Genomics - RNA splicing and chromatin remodeling prominent processes for adult neurogenesis
Genetics & Genomics - Researchers' findings advance genetics & genomics research
Gliomas - Efficacy of treating malignant gliomas with sulfasalazine examined
Gliomas - Nm23 expression may suppress glioma migration and invasion
Gliomas - Prognosis of glioma linked to increased expression of CCAAT/enhancer binding protein 6
Gliomas - Recent findings in gliomas described
HIV/AIDS Pathogenesis - HIV infection in astrocytes altered by cytokine priming
HIV/AIDS-Associated Dementia - AIDS-associated neuronal loss may be due to neuronal apoptosis
Hand Preference - The evolution of handedness compared in modern and medieval times
Healthcare Costs - Hospital resources are consumed in treating complications associated with PCI
Hypertension - Recent findings in hypertension described
Imaging - After transient cerebral ischemia, T1-weighted MR images may represent irreversible tissue injury
Insomnia - Insomnia treatment by ramelteon had mild or moderate adverse reactions
Ischemia - Recent studies add new data to ischemia research
Legal Issues - Shire sues Teva regarding ANDA for generic versions of ADHD medicine in six doses
Lipid Research - Titan initiates phase 2 study of DITPA in treatment of elevated cholesterol levels
Market Analysis - Ortho-McNeil Neurologics-sponsored analysis identifies top 10 migraine hot spots in U.S.
Medical Devices - Findings in medical devices provide new insights
Medical Devices - Micrus Endovascular receives approval to sell neurovascular stent in Europe
Medulloblastomas - Array comparative genomic hybridization analysis of medulloblastomas performed
Medulloblastomas - Childhood central nervous system tumors were not linked to expression of Gas7
Medulloblastomas - Medulloblastoma treated by histone deacetylase inhibitors
Meningiomas - Malignant meningioma detected as second malignancy after therapy for leukemia
Mergers & Acquisitions - Cardium acquires InnerCool Therapies, a provider of therapeutic hypothermia systems
Mergers & Acquisitions - Covalent enters into combination agreement with Remedium Oy
Multiple Sclerosis - HLA typing of MS patients may help identify patients for alternative therapies
Muscle Spasms - Botulinum toxin-A injections for spastic toe clawing reduces spasticity
Myeloma - Myeloma study using thalidomide shows improved remission rates
Natural Products - Echium amoenum may have some antidepressant activity
Neuroblastomas - Biology of neuroblastomas detected by mass screening was studied
Neuroblastomas - Outcome of neuroblastoma patients determined by metastatic recurrence, not extent of resection
Neurogenesis - Neurogenesis occurs in neuroinflammatory lesions in the adult spinal cord
Neurology - Brain structure is influenced by hyperglycemia and hypoglycemia in type 1 diabetes
Neurology - Diabetes patients' cognitive impairments arise from microvascular changes
Neurology - Metabotropic receptors are coupled to cGMP levels in certain neural cell types
Neurology - Rosuvastatin improves cerebrovascular function by inhibiting NAD(P)H oxidase
Neuroscience - Amarin reports Miraxion improves stress hormone transport
Neuroscience - MDMA maintains antiaggressive effects on behavior 3 weeks post administration
Neuroscience - Sema3A is neuroprotective of injury mediated by activated microglia
Neuroscience - Sympathetic nervous dysfunction involving sinus node is present in de novo Parkinson disease
Neurotology - Preserving hearing with ear tumor removal
Nicotine Addiction - A nicotine addiction neurocomputational hypothesis has been developed
Obstetrics - Mission Pharmacal Company introduces new Citracal prenatal + DHA as prenatal vitamin
Oncology - Brain tumor angiogenesis is regulated by NG2
Ophthalmology - Eyes with retinal ischemia improve after receiving XIAP gene therapy
Orthopedics - U.S. FDA approves label change to include physician dosing option for joint fluid therapy
Osteoarthritis - Nuvo announces Pennsaid data reviewing four trials was published in the Journal of Rheumatology
Osteoporosis - Reports advance knowledge in osteoporosis research
Pain & Obesity - Obese people reported to be more sensitive to pain
Pain Management - Placebo treatment for back pain produced comparable increases in relief to clinical and experimental interventions
Pain Management - SpineMED decompression table rehydrates spinal discs to relieve pain
Parkinson Disease - Parkinson disease behavioral recovery induced by stem cell-derived neurons
Parkinson Disease - Parkinsonian symptoms may involve mitonchondrial ATP-sensitive potassium channels
Parkinson Disease - Patients with Parkinson disease require careful dopaminergic treatment evaluation
Personnel - Genesis Bioventures announces addition of international scientist to scientific advisory board
Personnel - Gentiva announces new executive appointments and promotion of CFO
Personnel - Myriad Pharmaceuticals names Jose Fojas as vice president of marketing
Pharmaceutical Research - Phase III drugs slated to add additional $30 billion in revenues by 2010
Physiology - Receptor overexpression exaggerates locomotor and hypothermic response
Prostate Cancer - Proteome Systems Limited announces 60.6% increase in revenue for the half year
Proteomics - Neonatal PBDE-99 exposure could contribute to persistent neurotoxic effects
Proteomics - Reports describe recent advances in proteomics research
Radiation Therapy - Radiation therapy is associated with significant loss of bone mineral
Schizophrenia - Schizophrenia potential therapeutic target identified
Schizophrenia - Schizophrenia symptoms did not improve when risperidone was added to clozapine
Scoliosis - Adolescent scoliosis patients treated surgically are at risk for distal junctional kyphosis
Sleep Apnea - Sleep apnea syndrome patients had a high prevalence of high serum creatine phosphokinase levels
Spinal Cord Injury - Neuronal response in spinal cord injury may involve IL-6 stimulation of the Janus kinase pathway
Spondylolisthesis - Fusion of the health L4/5 segment can be avoided in developmental spondylolisthesis
Stem Cell Research - Astrocytes can induce hematopoietic stem cells to differentiate into neural cells
Stem Cell Research - Embryonic stem-like cells from canine blastocytes isolated and characterized
Stem Cell Research - Intrinsic determinants of midbrain dopamine neurons identified
Stem Cell Research - Neural stem cell maintenance and gliogenesis requires brahma-related gene 1
Stem Cell Research - Neuronal differentiation decreased by ethanol in a dose-dependent manner
Stem Cell Research - Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo
Stem Cell Research - Oregon IRB approves phase 1 trial using purified human neural stem cells in Batten disease
Stem Cell Research - Stem cell attraction to their niche related by sympathetic nervous system
Stem Cell Therapy - Neural progenitor transplant restores metabolic deficits in Huntington disease model
Stem Cell Transplantation - Researchers' data advance stem cell transplantation research
Surgical Technology - Aortic aneurysm repair with stented elephant trunk is linked to increased spinal cord injury risk
Surgical Technology - Endovascular stent-graft placement in aortic dissection compares favorably with surgical treatment
Surgical Technology - Freehand two-step CT-guided brain tumor biopsy is safe and effective
Temporomandibular Disorders - Temporomandibular disorder symptoms can be relieved by cognitive behavior therapy
Vagus Nerve Stimulation - Vagus nerve stimulation does not significantly influence body weight in epilepsy patients
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