Pain and Central Nervous System Week
Susan Hasty, Publisher
Table of Contents . . . July 3rd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pain and Central Nervous System Week | Other Publications
Drug Development - Hebrew University scientists develop potential new epilepsy drug
Huntington Disease - Gene therapy preserves motor function, stops cellular changes in mice with Huntington Disease
Pain Management - Neuropathic pain reduction correlates with improved quality of life
Spinal Cord Injury - Directed nerve regrowth after spinal cord injury induced by alginate-based ACH
Acoustic Neuroma - Acoustic neuroma conservative management requires further studies
Addiction Medicine - Opioid addicts demonstrate opioid-induced hyperalgesia
Addiction Medicine - Pain reduces psychosocial function during methadone treatment of opiate-dependence
Addiction Medicine - Tachykinin NK3 receptor antagonist blocks behavioral effects of cocaine
Allergy & Immunology - Specific TRP channels are activated by derived flavors and skin sensitizers
Alzheimer Disease - A number of patients with slight cognitive deterioration will suffer from Alzheimer Disease
Alzheimer Disease - Alzheimer's disease-associated predictors of unprovoked seizures are identified
Alzheimer Disease - Calorie restriction may prevent Alzheimer through promotion of longevity program in the brain
Alzheimer Disease - Isoflurane induces apoptosis and increases amyloid beta protein levels
Alzheimer Disease - Variants of a simple sugar ameliorate Alzheimer-like disease
Alzheimer Disease Vaccine - Anti-A-beta single-chain antibody reduces amyloid load in Alzheimer mouse model
Anesthesia - Bispectral index scores are lower for moderate hypothermic cardiopulmonary bypass
Angiology - Brain AVM risk factors for spontaneous intracranial hemorrhage identified
Ankylosing Spondylitis - Abbott's Humira is approved in Europe to treat severe ankylosing spondylitis
Antisense Technology - Suppressed c-fos expression impairs long-term memory in aversive taste learning
Arthritis - Decline in physical functioning for women in midlife may begin earlier than expected
Attention Deficit Hyperactivity Disorder - Alliant Pharmaceuticals re-launches Methylin chewable tablets
Autoimmune Disease - Anticardiolipin detection in infants best assay to evaluate disappearance of maternal aPL
Bacterial Meningitis - MMP-9 and MMP-8/-13 are upregulated in CSF during aseptic and bacterial meningitis
Bone Formation - Cbl-b downregulates bone formation via in osteoblasts during denervation
Business Update - Bristol-Myers Squibb extends neuroscience alliance with Lexicon Genetics
Business Update - Collegium Pharmaceutical announces development milestone under Cypress Bioscience agreement
Business Update - Curis initiates strategic plan focused on later-stage drug development
Business Update - Dainippon Sumitomo and Chelsea Therapeutics sign licensing agreement for hypotension agent
Business Update - Diagnostic Ultrasound introduces rigid stylet for fast, easy endotracheal intubation
Business Update - San Francisco Bay physician performs minimally invasive outpatient herniated disc procedure
Cardiology - alpha2 -adrenoceptor agonists as adjuncts to surgery considered in review
Cardiology - Ischemic cardiomyopathy mortality risk predicted by Microvolt T-wave alternans
Cardiology - St. Jude Medical gets Japanese approvals of computer system to treat irregular heartbeats
Cardiovascular Disease - Socio-economic differences among angina patients play role in CHD outcomes
Cardiovascular Research - Cardium reports meta-analysis findings of angiogenic gene therapy studies in heart disease
Cauda Equina Tumors - Early cauda equina tumor diagnosis is necessary
Cell Physiology - EagI potassium channel functions silenced by RNA interference
Central Nervous System - Therapeutic vaccination for central nervous system repair reviewed
Chronic Myelogenous Leukemia - Cell Genesys reports long-term follow-up data from Phase 2 trial of GVAX immunotherapy in CML
Clinical Trials - Avanir reports safety update from ongoing study of Neurodex
Clinical Trials - Cardioversion sedation with propofol a better choice for elders than midazolam
Clinical Trials - Clinical data on BioPharm's Volociximab (M200) presented at ASCO
Clinical Trials - Cytokinetics announces presentation of clinical trials data at ASCO
Clinical Trials - Hollis-Eden gets U.S. Food and Drug Administration clearance to begin human studies of Neumune
Collaborations - Cytopia announces major license and R&D collaboration
Collaborations - Spectral, Toray Medical form therapeutic strategic alliance for severe sepsis management
Colon Cancer - Colon cancer-related neuropathy due to oxaliplatin chemotherapy reduced by oral N-acetylcysteine
Colorectal Cancer - Data evaluating cetuximab in combination with chemotherapy for colorectal cancer reported
Developmental Biology - Bone formation stimulated recombinant human bone morphogenetic protein-2 system
Diabetes Pain Management - Curcumin attenuates thermal hyperalgesia in diabetic mouse model of neuropathic pain
Diabetes Pathogenesis - PPARG agonist rosiglitazone can elevate ADIPOR2 expression in hepatocytes
Diabetes Prevention - Glucocorticoid regulator response to exercise is tissue specific in hamster model
Diabetes Research - Long-term study shows brain function not impaired by tight diabetes control and hypoglycemia
Diabetic Neuropathy - Clinical manifestations and treatment options for diabetic neuropathies reviewed
Diabetic Retinopathy - Diabetic retinopathy laser therapy upsets circadian rhythms
Diabetic Retinopathy - Neuroretinal cells in diabetic retinopathy models respond to systemic IGF therapy
Diet & Nutrition - Health Canada approves use of Martek's DHA oil in foods
Disease Associations - Coronary artery disease associated with Alzheimer disease neuropathology in APOE4 carriers
Drug Abuse - Study provides first evidence aversion to drug withdrawal effects compulsive use, craving
Drug Development - Cell Genesys and Medarex announce interim results from Phase 1 combination therapy trial
Drug Development - Cortex announces update on CX717 clinical hold
Drug Development - Data at ASCO demonstrate potential of Velcade for injection across solid and hematological cancers
Drug Development - Data presented at ASCO on anti-cancer compound ON 01910.Na in brain cancer
Drug Development - Neuroblastoma cell death induced by docosahexaenoic acid warrants further study
Drug Safety - MHRA concludes updated survival analysis on antidepressant venlafaxine, lists main points
Emergency Medicine - Stroke time to treatment with IV t-PA reduced with an ED triage strategy
Endocrinology - Ghrelin in preterm neonates gradually increases
Endocrinology - Growth hormone receptor messenger ribonucleic acid variants identified in adipocytes
Endotracheal Tube - Endotracheal tube size in perinatal patients should be based on anatomical data
Environmental Health - Cerebrovascular disease admissions linked to air pollution levels of O3 , CO in Taipei
Environmental Health - Gas-phase ambient air contaminants show significant dioxin- and estrogen-like activity
Epilepsy - Temporal lobe epilepsy patients gain normalization of QOL with lobectomy
Epilepsy Therapy - Use of anti-epileptic drugs increasing in Denmark
Fibromyalgia - Acupuncture relieves symptoms of fibromyalgia, Mayo Clinic study finds
Finance - Hercules Technology provides $10 million financing to TransOral Pharmaceuticals
Finance - St. David's Foundation awards $812,000 in mental health service grants to 12 organizations
Gastroenterology - Impact of aspirin and NSAID or cyclo-oxygenase-2-selective inhibitor on gastric ulcers examined
Gene Research - Organ-specific gene expressions in C57BL/6 mice occur after exposure to low-dose radiation
Genetically Modified Cells - Genetically modified Schwann cells provide transplants in nerve regeneration
Genetics & Genomics - Clinical Data announces 2006 launch of genetic test for warfarin response
Genetics & Genomics - Hypertrophic cardiomyopathy and apical aneurysm reported in case of identical twins
Genetics & Genomics - Serum- and glucocorticoid-induced protein kinase-1 gene involved in energy homeostasis
Glioblastoma - Favorable safety results reported in study of investigational treatment for glioblastoma
Glioblastoma Multiforme - NeoPharm announces PRECISE trial has reached criteria for interim efficacy analysis
HIV Pathology - Cooperativity transcription factors modulate HIV-1 activation in astrocytes
HIV/AIDS Dementia - Development and expression of HIV-related dementia is evolving in the HAART era
HIV/AIDS Neuropathy - Protease inhibitor exposure is a risk factor for sensory neuropathy development
HIV/AIDS Ocular Syphilis - Ocular syphilis incidence high among HIV-infected patients receiving HAART
HTLV-1-Associated HAM/TSP - HCD4 cells positive for NKG2D in HTLV-1-associated myelopathy/tropical spastic paraparesis
Headache & Migraine - Natural course of migraine attacks described
Health Promotion - PhRMA launches campaign to improve heart disease and stroke awareness
Hearing Disorders - Cochlear alterations identified in deaf and unaffected subjects
Hearing Loss - Non-Hispanic black women may have best hearing in U.S., new study shows
Heart Failure - Aerobic training of heart failure patients decreases BNP and adrenergic activation
Hepatitis B Virus - Heat shock protein gp96 affects dendritic cell maturation and CTL expansion
Hypertension - Serial changes in left ventricular hypertrophy indices predict cerebrovascular events
Idiopathic Scoliosis - Paradigm Spine to fund genetic research to introduce a diagnostic test predict idiopathic scoliosis
Imaging - Contrast-enhanced ultrasonography may be used to assess cerebral perfusion
Imaging - Coronary CT angiography examined in a review
Implants - Innovasis submits OpteryX cervical plate system for U.S. Food and Drug Administration clearance
Inflammatory Arthritis - Targeted Genetics reports study data on inflammatory arthritis product development platform
Intracranial Atherostenosis - Metabolic syndrome may not be a predictive factor in intracranial atherostenosis prognosis
Intracranial Ependymoma - Intracranial ependymoma and choroid plexus papilloma tumorigenesis linked to methylation pattern
Lumbar Spinal Stenosis - Lumbar spinal stenosis diagnostic test accuracy is assessed
Lung Cancer - Results of studies show progression free survival advantage for ZD6474 in lung cancer
Mantel Cell Lymphoma - Clinical study shows efficacy of single-agent Velcade in treating mantle cell lymphoma
Market Analysis - Spending on biotech drugs to treat inflammatory diseases up 33.9% in 2005, report says
Market Analysis - Study looks at Australian analgesics sector
Mental Health - Clues help to distinguish nonepileptic seizures from those caused by epilepsy
Mental Health - Study shows long-term treatment ineffective in patients with treatment-resistant depression
Migraine Headache - Migraine attacks associated with increased QTc and P-wave dispersion
Migraine Headache - Survey reveals worrying between attacks can extend suffering for people with migraines
Multiple Myeloma - Cytogen announces positive interim Phase I findings in QUADRAMET combination study
Multiple Myeloma - Thalidomide delays disease progression in newly diagnosed multiple myeloma, study shows
Multiple Sclerosis - Betaferon approved in Europe as a first-line therapy for early stages of MS
Myasthenia Gravis - Myasthenia gravis can be consistently diagnosed with RNS to facial muscles
Nerve Regeneration - Nerve allograft treatment with FK506 induces better regeneration than other immunosuppressants
Neurology - Abnormal glucose metabolism may contribute to chronic nerve disorder
Neurology - Basal ganglia of the subthalamic nucleus play a role in generating speech
Neurology - Erotic images elicit strong response from brain
Neurology - Migraine prophylactic treatment with N-alpha-methylhistamine is effective
Neurology - Salk and Stanford teams join forces to reveal two paths of neurodegeneration
Neuroprotection - Autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
Neuroscience - Amyloid precursor protein is involved in neural progenitor cell differentiation
Neuroscience - Ca2+ subunits translocate to nuclei and promote toxicity
Neuroscience - Focal cerebral ischemic damage can be salvaged by hemoglobin polymer transfusion
Neuroscience - Intracranial aneurysm susceptibility increased by a haplotype
Neuroscience - Mutant huntingtin aggregates impair mitochondrial function in cortical neurons
Neuroscience - Prefrontal cortex gene expression altered by chronic smoking and alcoholism
Neuroscience - Prion protein amyloid fibrils are toxic to cultured cells and primary neurons
Neuroscience - Rac3-induced neuritogenesis requires binding to Neurabin I
Obesity Epidemiology - Melanocortin-4 receptor gene mutations causing impaired function were rare
Obesity Pathogenesis - Melanocortin-4 receptor activation mobilizes calcium in immortalized hypothalamic neurons
Obesity Pathogenesis - Neuropeptide YY5 antagonist ameliorates body weight in diet-induced obese mice
Obesity Pathogenesis - Peptide YY ablation in mice leads to hyperinsulinemia and obesity development
Obesity Pathogenesis - Peptide YY may play key role in appetite control and weight loss after bariatric surgery
Obesity Research - Researchers identify potential link between diabetic memory loss and hormone levels
Obesity Therapy - Heliosphere Bag cannot be considered temporary treatment of morbid obesity
Obsessive-Compulsive Disorder - OCD high-frequency anterior capsular stimulation treatment is studied
Olfactory Neuroblastoma - Olfactory neuroblastoma cytopathologic features described
Orthopedics - Chronic and disabling spine disorders linked with psychiatric disorders
Orthopedics - Clubfoot patients treated with extensive soft-tissue release have poor outcomes
Orthopedics - Glenohumeral hemiarthroplasty provides sustained pain relief and functional improvement
Orthopedics - Mechanical neck disorder therapies are reviewed
Orthopedics - Periarticular multimodal drug injection is effective during total knee arthroplasty
Orthopedics - Periprosthetic femoral fractures satisfactorily treated with proximal femoral allografts
Osteoporosis - Osteoporotic compression vertebral fractures are successfully treated with PV
Otorhinolaryngology - Connexin-associated deafness can be effectively treated with cochlear implantation
Pain Management - Alexza initiates AZ-001 phase IIb trial in patients with migraine headaches
Pain Management - BioElectronics finalizes design for new retail footcare product
Pain Management - Botulinum toxin A is effective treatment for chronic low back pain
Pain Management - Chronic pain treatment with intrathecal opioids is effective in preliminary studies
Pain Management - First patient enrolled in phase 3 pain study for injectable NSAID diclofenac sodium
Pain Management - Nephrectomy donors benefit from laparoscopic versus open surgery
Pain Management - Postsurgical pain identification, prevention, and treatment strategies are presented
Pain Management - Self-report inventory to identify barriers to pain management developed
Parkinson Disease - Gene mutation may influence age at onset of Parkinson disease
Parkinson Disease - Study concludes that pesticide use increases risk of Parkinson in men
Pediatric Oncology - Childhood cancer incidence in Ontario trended and projected
Personnel - Cerimon Pharmaceuticals names James Welch as chief financial officer
Personnel - Corgentech announces appointment of two executive positions
Personnel - H. Ward Wolff elected to board of directors, chair of Sangamo BioSciences audit committee
Personnel - InfaCare announces formation of new product advisory board
Personnel - Quantum Genomics Corp names Lionel Segard as CEO
Primary Hyperaldosteronism Diagnostics - Primary hyperaldosteronism subtypes are best diagnosed by adrenal vein sampling
Primary Hyperparathyroidism - PHPT-associated adenoma factors that lead to negative imaging studies are identified
Primary Hyperparathyroidism - Primary hyperparathyroidism neuropsychologic symptoms may be assessed with fMRI
Primary Hyperparathyroidism - Primary hyperparathyroidism-associated cognitive disorders are improved with surgery
Prion Proteins - Recombinant prions interact with compounds of therapeutical significance
Prostate Cancer - Cell Genesys recaps two presentations from 2006 ASCO Annual Meeting
Prostate Cancer - Cytogen presents promising data from combination trials with QUADRAMET and Docetaxel
Proteomics - Dementia with Lewy bodies may be associated with reduced UCHL-1 expression
Pruritus - Pruritus incidence and severity is reduced by intraoperative propofol administration
Retinopathy - Astrocytes in models with oxygen-induced retinopathy overexpress protein kinase CK2
Rhabdoid Tumors - Rhabdoid tumor diagnosis linked to SMARCB1/INI1 expression
Schizophrenia - Drug to treat schizophrenia using a new mechanism now available in Japan
Sexual & Reproductive Health - Chronic pelvic pain improves with combined Mensendieck somatocognitive/gynecologic therapy
Sexual & Reproductive Health - Migraine headaches and sexual desire may be linked
Sirtuins - Sirtris completes dosing in phase 1 safety trial of metabolic-targeting sirtuin therapeutic
Spinal Cord Injury - Cyberkinetics reports first data from paralyzed participant in neural interface study
Spinal Cord Injury - Nonmissile penetrating spinal injury management is discussed
Stem Cell Research - Aqaporin-4 and -9 are expressed in adult subventricular zone-derived neural stem cells
Stem Cell Research - Functional neural structures generated by inkjet printing method
Stem Cell Research - Neural stem cell proliferation decreased in schizophrenia but not depression
Stem Cell Research - Stem cells found in adult skin can be transplanted and function in mouse models of disease
Stomach Cancer - Docetaxel and oxaliplatin study shows promise in gastroesophageal and/or stomach cancer
Stroke - 99mTc-HYNIC-annexin VSPECT imaging useful for monitoring stroke therapy
Stroke - Myocardial injury indicated by elevated cTnT level linked to right insular infarction
Stroke - New study aims to help stroke patients walk correctly again
Stroke - Stroke, cerebral infarction risk associated with larger retinal venular diameters
Tissue Engineering - Transplantable retinal pigment epithelial cell sheet fabrication analyzed
Alzheimer Disease - Research from Japan, the United States and Israel in Alzheimer disease provides new insights
Cancer Research - Reports from the United States and People's Republic of China describe recent advances in cancer research
Cancer Treatment - Recent findings from Spain, the South Korea and Slovenia illuminate research in cancer treatment
Cancer Treatment - Research from the United States in cancer treatment provides new insights
Cancer Treatment - Researchers from Canada, the United States and France detail new studies and findings in the area of cancer treatment
Cell Biology - Research from Japan and the United States add new data to cell biology body of knowledge
Diabetes - New research from the United States and Italy in the area of diabetes detailed
Diabetes - Recent studies from Italy, the United States and Austria add new data to diabetes research
Diabetes - Reports from Japan, Netherlands and the United States add new data to diabetes research
Diabetes - Reports from the United States, Sweden and Brazil advance knowledge in diabetes research
Diabetes - Research from the United States and Japan add new data to diabetes body of knowledge
Diabetes - Researchers from the United States, South Korea and France report recent findings in diabetes
Diabetes - Researchers' findings from Japan and the United States advance diabetes research
Diagnostics - Studies from Japan, Canada and Netherlands describe new findings in diagnostics research
Endocrinology - New research from Denmark, Spain and Italy in the area of endocrinology detailed
Endocrinology - Researchers from France and the United States report recent findings in endocrinology
Endocrinology - Researchers from the United States describe findings in endocrinology studies
Epstein-Barr Virus - New research from the United States, Taiwan and Japan in the area of Epstein-Barr virus detailed
Genetics - Recent findings from Japan, the United States and the United Kingdom illuminate research in genetics
Genetics - Recent studies from the United States and United Kingdom add new data to genetics research
Genetics - Researchers from South Korea, Italy and Germany describe findings in genetics studies
Genetics - Studies from the United States, Germany and Italy add new findings to genetics body of knowledge
HIV/AIDS - Researchers from Thailand and the United States report recent findings in HIV/AIDS
HIV/AIDS - Researchers' work from the United States and Brazil adds to HIV/AIDS body of knowledge
HIV/AIDS - Studies from the United States and Austria describe new findings in HIV/AIDS research
HIV/AIDS - Studies from the United States, France and United Kingdom advance knowledge in HIV/AIDS research
Ischemia - Findings from the United States and Canada in ischemia provide new insights
Macular Degeneration - Researchers from the United States, United Kingdom and People's Republic of China detail new studies and findings in the area of macular degeneration
Neurology - New research from Turkey, Germany and the South Korea in the area of neurology detailed
Neurology - Research from the United States, Italy and Japan add new data to neurology body of knowledge
Neurology - Researchers from Japan, the United States and Germany report recent findings in neurology
Neurology - Researchers from the United States report recent findings in neurology
Pain - New research from Denmark and the United States in the area of pain detailed
Schizophrenia - New findings from the United States and Scotland in the area of schizophrenia detailed
Surgery - Researchers from the United States and Turkey detail new studies and findings in the area of surgery
Tuberculosis - Findings from the United States and Japan describe new data in tuberculosis research
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