Vector Development
Adenoviral gene therapy to central nervous system may be damaging
Published in Pain and Central Nervous System Week, July 17th, 2006
"Model systems have shown that adenoviral vector-mediated transient gene expression can potentially be applied for the treatment of brain tumors, neurodegenerative diseases, and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report, we have systematically characterized CAR expression in the adult human central nervous system (CNS) by using immunohistochemistry," researchers in Sweden...
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