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Ophthalmology

Apolipoprotein localized in isolated drusen and retinal apolipoprotein gene expression

Published in Pain and Central Nervous System Week, August 28th, 2006

In a recent study, researchers in the United States reported on the localization of apolipoprotein (Apo) in isolated drusen and retinal apolipoprotein gene expression.

C.M. Li and colleagues, University of Alabama, wrote that the study was done "to evaluate Apo gene expression in native human retinal pigment epithelium (RPE) and neurosensory retina and to detect apolipoproteins within age-related, extramacular drusen."

"Drusen were isolated manually from 10 eyes of 10 donors (age range, 58 -93 years) with grossly normal macular that were preserved in 4% paraformaldehyde within 6 hours of death. In cryosections of druse-enriched pellets (6-57 drusen...

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