Published in Pain and Central Nervous System Week, September 18th, 2006
Study 1: Enhanced phosphatidylinositol(3,4,5)-trisphosphate signaling in proopiomelanocortin neurons causes KATP channel activation and leads to diet-sensitive obesity.
"Leptin and insulin have been identified as fuel sensors acting in part through their hypothalamic receptors to inhibit food intake and stimulate energy expenditure. As their intracellular signaling converges at the PI3K pathway, we directly addressed the role of phosphatidylinositol(3,4,5)-trisphosphate-mediated (PIP3-mediated) signals in hypothalamic proopiomelanocortin (POMC) neurons by...
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