Acute Lymphoblastic Leukemia

Methotrexate treatment is associated with good long-term neurocognitive outcomes

Published in Pain and Central Nervous System Week, October 23rd, 2006

Treatment strategies for young children with acute lymphoblastic leukemia (ALL) that avoid cranial radiation therapy (CRT) are associated with good long-term neurocognitive outcomes.

"CRT is associated with neurocognitive morbidity in survivors of childhood ALL. For most patients, CRT has been replaced with intensified systemic and intrathecal chemotherapy, often including methotrexate (MTX). The impact of chemotherapy-only protocols on neurocognitive outcomes is unclear, and the importance of systemic MTX dose has not been established," investigators in Canada report.

"Seventy nine of 120 eligible children diagnosed with high-risk ALL between the...

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Source: Pain and Central Nervous System Week (2006-10-23)

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