Glioma
Mechanism of glioma invasiveness studied
Published in Pain and Central Nervous System Week, November 13th, 2006
According to a study from Brazil, "Invasive behavior is the pathological hallmark of malignant gliomas, being responsible for the failure of surgery, radiation, and chemotherapy. Matrix metalloproteinases (MMPs) are essential for proper ECM remodeling and invasion."
"The tumor and metastasis suppressor RECK protein regulates at least 3 members of the MMPs family: MMP-2, MMP-9, and MT1-MMP. In order to mimic the in vivo invasion process, A172 and T98G, respectively, non-invasive and invasive human glioblastoma cell lines, were cultured onto uncoated (control) or type I collagen gel-coated...
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