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Neurology

New treatments prevent brain injury hours after stroke in rats

Published in Pain and Central Nervous System Week, January 15th, 2007

Two novel treatments - a basic compound found in every cell in the body and an extract of green tea - may prevent brain damage caused from stroke, according to two studies in rats led by a researcher at the San Francisco VA Medical Center.

Both treatments were administered through the nose, rather than intravenously, the conventional method for delivering drugs to the brain.

In one study, rats' brains were subjected to ischemia - severely reduced blood flow - for two hours in a model of stroke. Researchers then administered nicotinamide adenine dinucleotide, or NAD+, immediately after "reperfusion," or resumption of blood flow. Reperfusion is the...

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