Alzheimer Disease

Studies from M. Mihailovich and colleagues provide new data on alzheimer disease

Published in Pain and Central Nervous System Week, September 17th, 2007

"BACE1 is the protease responsible for the production of amyloid-beta peptides that accumulate in the brain of Alzheimer's disease ( AD) patients. BACE1 expression is regulated at the transcriptional, as well as post- transcriptional level," scientists in Milan, Italy report.

"Very high BACE1 mRNA levels have been observed in pancreas, but the protein and activity were found mainly in brain. An up-regulation of the protein has been described in some AD patients without a change in transcript levels. The features of BACE1 5' untranslated region (5' UTR), such as the length, GC content, evolutionary conservation and presence of upstream AUGs ( uAUGs), indicate an...

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Source: Pain and Central Nervous System Week (2007-09-17)

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