Neurofibromatosis

Research conducted at I.S. Ho and co-authors has provided new information about neurofibromatosis

Published in Pain and Central Nervous System Week, September 17th, 2007

"Neurofibromatosis type 1 (NF1) is a dominant genetic disorder that causes tumors of the peripheral nervous system. In addition, > 40% of afflicted children have learning difficulties," investigators in the United States report.

"The NF1 protein contains a highly conserved GTPase-activating protein domain that inhibits Ras activity, and the C-terminal region regulates cAMP levels via G-protein-dependent activation of adenylyl cyclase. Behavioral analysis indicates that learning is disrupted in both Drosophila and mouse NF1 models. Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1 mutants. In the present...

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Source: Pain and Central Nervous System Week (2007-09-17)

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