Alzheimer Disease

Low level of neuronal receptor linked to mild cognitive impairment and Alzheimer's disease

Published in Pain and Central Nervous System Week, September 17th, 2007

Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease.

LR11, like all receptors, selectively receives and binds specific substances. Researchers found reduced levels of LR11, also known as sorLA or SORL1, in the brain tissue of people diagnosed with MCI. In addition, the findings show that levels of LR11 in the brain tissue reflect the severity of cognitive impairment and may predict which individuals will progress to Alzheimer's disease.

Results of the study by scientists at Emory University School of Medicine, along with...

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Source: Pain and Central Nervous System Week (2007-09-17)

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