Pain & Central Nervous System Week
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Parkinson Disease
New findings reported from University College describe advances in Parkinson disease
November 19th, 2007
According to recent research from London, the United Kingdom, "The safety and tolerability of adjunctive tolcapone initiated simultaneously with levodopa was evaluated with a focus on increases in liver transaminase and hepatotoxicity 677 levodopa- naive patients with early stage Parkinson's disease ( PD) were randomised to receive placebo or tolcapone 100 mg three times daily, added to standard doses of levodopa plus carbidopa or benserazide Increases in liver transaminase above the upper limit of normal ( ULN) occurred in 69/ 342 ( 20.2%) and 92/ 335 ( 27.5%) patients in the placebo and tolcapone groups, respectively. Increases >= 3 times the ULN occurred in 4/ 342 ( 1.2%) and 6/ 335...
Source: Pain & Central Nervous System Week (2007-11-19)
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