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Prion Disease
New research on prion disease from University of Paris summarized
November 19th, 2007
"Peripherally acquired transmissible spongiform encephalopathies display strikingly long incubation periods, during which increasing amounts of prions can be detected in lymphoid tissues. While precise sites of peripheral accumulation have been described, the mechanisms of prion transport from mucosa. and skin to lymphoid and nervous tissues remain unknown," investigators in Paris, France report. "Because of unique functional abilities, dendritic cells (DCs) have been suspected to participate in prion pathogenesis. In mice inoculated subcutaneously with scrapie-infected DCs, the incubation was shorter when cells were alive as compared with killed cells, suggesting that...
Source: Pain & Central Nervous System Week (2007-11-19)
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