Arthritis

Studies from University of Amsterdam have provided new data on arthritis

Published in Pain and Central Nervous System Week, January 28th, 2008

According to recent research published in the journal Rheumatology, "All complement pathways lead to the formation of C5a, which is believed to contribute to the influx and activation of C5a-receptor (C5aR) bearing cells into the joints of patients with rheumatoid arthritis (RA). Studies in animal models of RA have suggested therapeutic potential of C5aR blockade."

"In this study, we examined the effects of the C5aR blockade on synovial inflammation in RA patients. We performed a double-blind, placebo-controlled study using an orally administered C5aR-antagonist. Twenty-one patients with active RA were randomized 2:1 to treatment with a C5aR-antagonist AcF-...

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Source: Pain and Central Nervous System Week (2008-01-28)

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