Anesthesia

2 different neural pathways regulate loss and regain of consciousness during general anesthesia

Published in Pain and Central Nervous System Week, January 28th, 2008

University of Pennsylvania School of Medicine researchers have answered long-running questions about the way that anesthetics act on the body, by showing that the cellular pathway for emerging from anesthesia is different from the one that drugs take to put patients to sleep during operations. The findings will be published this week in Proceedings of the National Academy of Sciences.

The research focuses on orexins, the small, specialized fraction of the brain’s 100 billion neurons that play a key role in regulating the body’s wakeful state. Studying mice whose orexin systems had been genetically destroyed – a state similar to humans suffering from narcolepsy, a...

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Source: Pain and Central Nervous System Week (2008-01-28)

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