Spectroscopy

Studies from Kyoto University have provided new information about spectroscopy

Published in Pain and Central Nervous System Week, March 24th, 2008

According to recent research from Kyoto, Japan, "The neurotoxicity of the 42-mer and 40-mer amyloid beta peptides (A beta 42 and A beta 340) is closely related to the radicalization at both Tyr10 and Met35. A beta 42 is more neurotoxic than A beta 40."

"Our previous structural analyses of A beta 42 suggested that Tyr10 and Met35 are brought closer together by the turn at positions 22 and 23, and the S-oxidized radical cation at position 35, which is the ultimate toxic radical species, can be produced effectively through oxidation by the phenoxy radical at position 10. To verify this idea, their separation was measured by site-directed spin labeling (MTSSL) by using ESR...

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Source: Pain and Central Nervous System Week (2008-03-24)

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