Pain & Central Nervous System Week
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Alzheimer Disease
Recent findings from Medical University of South Carolina highlight research in Alzheimer disease
September 1st, 2008
According to recent research published in the Journal of Neurochemistry, "Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the underlying mechanisms remain unknown. In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP) processing, the two key parameters of Alzheimer's disease pathogenesis." "Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet for an 8-week period and tested for memory in a radial arm maze. It...
Source: Pain & Central Nervous System Week (2008-09-01)
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