Pain & Central Nervous System Week
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Angiotensins
Study data from G.A. Arganaraz et al provide new insights into angiotensins
September 1st, 2008
"As reported by several authors, angiotensin II (AngII) is a proinflammatory molecule that stimulates the release of inflammatory cytokines and activates nuclear factor kappa B (NF kappa B), being also associated with the increase of cellular oxidative stress. Its production depends on the activity of the angiotensin converting enzyme (ACE) that hydrolyzes the inactive precursor angiotensin I (AngI) into AngII," scientists in Sao Paulo, Brazil report. "It has been suggested that AngII underlies the physiopathological mechanisms of several brain disorders such as stroke, bipolar disorder, schizophrenia, and disease. The aim of the present work was to localize and...
Source: Pain & Central Nervous System Week (2008-09-01)
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