Pain & Central Nervous System Week
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Encephalomyelitis
Researchers from Harvard University discuss findings in encephalomyelitis
September 1st, 2008
"The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental autoimmune encephalomyelitis (EAE)," researchers in the United States report. "We found that memory CD4(+) T cells up-regulated the activation marker CD44 as well as (CXCR3 and ICOS, proliferated more and produced more interferon-gamma and less interleukin-17 compared to effector T cells. Moreover, adoptive transfer of memory T cells into T cell receptor (TCR)alpha beta(-/-) recipients induced more severe disease than did effector CD4(+) T cells with marked central...
Source: Pain & Central Nervous System Week (2008-09-01)
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