Pain & Central Nervous System Week
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Endocytosis
New findings from N. Shin and co-authors describe advances in endocytosis
September 1st, 2008
According to a study from South Korea, "The leucine-rich repeat kinase 2 (LRRK2) has been identified as the defective gene at the PARK8 locus causing the autosomal dominant form of Parkinson's disease (PD). Although several LRRK2 mutations were found in familial as well as sporadic PD patients, its physiological functions are not clearly defined." "In this study, using yeast two-hybrid screening, we report the identification of Rab5b as an LRRK2-interacting protein. Indeed, our GST pull down and co-immunoprecipitation assays showed that it specifically interacts with LRRK2. In addition, subcellular fractionation and immunocytochemical analyses confirmed that a fraction...
Source: Pain & Central Nervous System Week (2008-09-01)
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