Pain & Central Nervous System Week
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Huntington Disease
Findings from New York Medical College, Medical College in Huntington disease reported
September 1st, 2008
"Transglutaminases (TGases) catalyze several reactions with protein substrates, including formation of gamma-glutamyl-epsilon-lysine cross-links and gamma-glutamylpolyamine residues. The resulting gamma-glutamylamines are excised intact during proteolysis," scientists in the United States report. "TGase activity is altered in several diseases, highlighting the importance of in situ enzymatic determinations. Previous work showed that TGase activity (as measured by an in vitro assay) and free gamma-glutamyl-epsilon-lysine levels are elevated in Huntington disease (HD) and that gamma-glutamyl-epsilon-lysine is increased in HD CSF. Although free...
Source: Pain & Central Nervous System Week (2008-09-01)
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