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HIV/AIDS

Reports from University of California advance knowledge in HIV/AIDS

Published in Pain and Central Nervous System Week, November 24th, 2008

"Objectives A minority of HIV-infected patients taking an antiretroviral (ARV) regimen containing dideoxynucleosides (d-drugs) such as stavudine (d4T) and didanosine (DDI) experiences dose-limiting neuropathic pain and paraesthesias, usually within weeks of starting these drugs. Because d-drugs are among the few affordable options available in developing countries, continuing d-drug therapy would be a desirable strategy for many HIV-infected individuals," investigators in the United States report.

"Therefore, we evaluated the safety of continuing d-drug therapy. In a US cohort, we compared the rates of worsening neuropathic symptoms and signs in HIV-infected...

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