Research
Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain
Published in Pain and Central Nervous System Week, January 12th, 2009
Scientists have identified an initiating molecular mechanism in sporadic Alzheimer's disease (AD). The study, published by Cell Press in the December 26th issue of the journal Neuron, provides new information about generation of damaging amyloid β (Aβ) plaques within the AD brain and underscores the importance of developing new preventative and disease-modifying therapies for AD, especially those aimed at interrupting pathological Aβ-production.
AD, the leading cause of dementia in the elderly, is a devastating neurological disorder characterized by accumulation and deposition of sticky clumps of A' protein. A' protein is generated from amyloid precursor...
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