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Columbia University Medical Center

Parkinson's: Neurons destroyed by 3 simultaneous strikes

Published in Pain and Central Nervous System Week, May 11th, 2009

In a study that reveals the clearest picture to date of neuron death in Parkinson's disease, researchers at Columbia University Medical Center have found that a trio of culprits acting in concert is responsible for killing the brain cells.

The study, published in the April 30 issue of Neuron, showed that three molecules – the neurotransmitter dopamine, a calcium channel, and a protein called alpha-synuclein – act together to kill the neurons.

The discovery gives researchers a new understanding of how to save the neurons, say the study's authors, Eugene Mosharov, Ph.D., associate research scientist, and David Sulzer, Ph.D., professor of neurology &...

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