University of California - San Diego
Novel role of protein in generating amyloid-beta peptide
Published in Pain and Central Nervous System Week, May 11th, 2009
A defining hallmark of Alzheimer's disease is the accumulation of the amyloid β protein (Aβ), otherwise known as "senile plaques," in the brain's cortex and hippocampus, where memory consolidation occurs. Researchers at the University of California, San Diego School of Medicine have identified a novel protein which, when over-expressed, leads to a dramatic increase in the generation of Aβ. Their findings, which indicate a potential new target to block the accumulation of amyloid plaque in the brain, will be published in the May 1 issue of the Journal of Biological Chemistry.
"The role of the multi-domain protein, RANBP9, suggests a possible new...
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