Pain & Central Nervous System Week
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Ataxia Telangiectasia
Studies from L. Carlessi and co-researchers in the area of ataxia telangiectasia published
July 27th, 2009
According to a study from Milan, Italy, "Ataxia-telangiectasia (A-T) is a neurodegenerative disorder caused by defects in the ATM kinase, a component of the DNA-damage response (DDR). Here, we employed an immortalized human neural stem-cell line (ihNSC) capable of differentiating in vitro into neurons, oligodendrocytes and astrocytes to assess the ATM-dependent response and outcome of ATM ablation." "The time-dependent differentiation of ihNSC was accompanied by an upregulation of ATM and DNA-PK, sharp downregulation of ATR and Chk1, transient induction of p53 and by the onset of apoptosis in a fraction of cells. The response to ionizing radiation (IR)-induced DNA...
Source: Pain & Central Nervous System Week (2009-07-27)
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