Epilepsy

New findings from C.C. Young and co-authors in the area of epilepsy published

Published in Pain and Central Nervous System Week, October 26th, 2009

According to a study from Freiburg, Germany, "In humans, temporal lobe epilepsy (TLE) is often associated with Ammon's horn sclerosis (AHS) characterized by hippocampal cell death, gliosis and granule cell dispersion (GCD) in the dentate gyrus. Granule cells surviving TLE have been proposed to be hyperexcitable and to play an important role in seizure generation."

"However, it is unclear whether this applies to conditions of AHS. We studied granule cells using the intrahippocampal kainate injection mouse model of TLE, brain slice patch-clamp recordings, morphological reconstructions and immunocytochemistry. With progressing AHS and GCD, 'epileptic' granule cells of the...

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Source: Pain and Central Nervous System Week (2009-10-26)

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