Bone Research

New findings from N. Tomomatsu and co-authors in the area of bone research published

Published in Pain and Central Nervous System Week, November 30th, 2009

According to recent research from Tokyo, Japan, "TNF-alpha is a major etiologic factor of inflammatory bone diseases such as periodontitis and rheumatoid arthritis. In addition, patients with metabolic diseases such as chronic heart disease and diabetes have significantly increased plasma levels of TNF-alpha."

"Several lines of evidence show inhibition of osteoblastogenesis by TNF-alpha in vitro. Therefore, bone formation and osteogenesis in these patients might be inhibited because of TNF-alpha. However, little is known about the inhibitory role of TNF-alpha in bone formation/osteogenesis in vivo. The purpose of this study was to investigate the role of TNF-alpha in...

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Source: Pain and Central Nervous System Week (2009-11-30)

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