Immunization

Data from University of Rochester provide new insights into immunization

Published in Pain and Central Nervous System Week, January 18th, 2010

New research, 'Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation,' is the subject of a report. "Cyclooxygenase (Cox) inhibitors are among the most widely used and commonly prescribed medications. Relatively little is understood about their influence on human immune responses," investigators in the United States report.

"Herein, we discovered a novel and important mechanism whereby non-steroidal anti-inflammatory drugs (NSAIDs) blunt human B-cell antibody production. We demonstrate that the Cox-2 selective small molecule inhibitors SC-58125 and NS-398 attenuate the production of...

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Source: Pain and Central Nervous System Week (2010-01-18)

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