Alzheimer Disease
Study Investigates Immune System Alterations In the Brain and May Shed Light On Alzheimers Disease-like Changes
Published in Pain and Central Nervous System Week, January 18th, 2010
Using laboratory mice that had been bred to have brain changes similar to Alzheimer's disease, scientists were able to reduce two characteristic features of the disease by modifying the mice's immune systems with a special peptide (MOG45D) related to the myelin sheath that insulates nerve cells and nerve fibers. As a result, anti-inflammatory cells were recruited from the blood into the brain, dampening the local inflammatory response.
An article published online by the Journal of Neurochemistry describes the immune intervention, its cellular and molecular mechanisms of action, and the effects on disease pathology.
The study...
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