Brain Cancer

New research on brain cancer from H. Wurdak and co-authors summarized

Published in Pain and Central Nervous System Week, March 22nd, 2010

According to a study from the United States, "Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer associated with a very poor prognosis. Recently, the initiation and growth of GBM has been linked to brain tumor-initiating cells (BTICs), which are poorly differentiated and share features with neural stem cells (NSCs)."

"Here we describe a kinome-wide RNA interference screen to identify factors that control the tumorigenicity of BTICs. We identified several genes whose silencing induces differentiation of BTICs derived from multiple GBM patients. In particular, knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured...

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Source: Pain and Central Nervous System Week (2010-03-22)

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