According to a study from Ikoma, Japan, "We recently demonstrated that SA13353 [1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons. In the present study, we investigated the effects of SA13353 on lipopolysaccharide (LPS)-induced cytokine production and a murine model of experimental autoimmune encephalomyelitis (EAE)."
"SA13353 inhibited LPS-induced TNF-alpha and interleukin (IL)-1 beta production while augmenting IL-10 production in mice. It also inhibited TNF-alpha and IL-1 beta mRNA expression, and...
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