Neuroblastomas
Findings from Medical University Advance Knowledge in Neuroblastomas
Published in Pain and Central Nervous System Week, September 19th, 2011
2011 SEP 19 -- According to the authors of recent research from Gdansk, Poland, "Inhibition of pyruvate (PDHC) and ketoglutarate (KDHC) dehydrogenase complexes induced by thiamine pyrophosphate deficits is known cause of disturbances of cholinergic transmission in the brain, yielding clinical symptoms of cognitive, vegetative and motor deficits. However, particular alterations in distribution of key acetylcholine precursor, acetyl-CoA, in the cholinergic neuron compartment of thiamine pyrophosphate-deficient brain remain unknown."
"Therefore, the aim of our work was to find out how amprolium-induced thiamine pyrophosphate deficits (TD) affect distribution...
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