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Antibiotics
In vitro, in vivo studies support development of pharmacodynamic parameters to determine drug dose
February 27th, 2006
In vitro and in vivo studies support development of pharmacodynamic parameters in order to determine drug dose. According to a study from the United States, "For antibiotics to exert their action on bacteria, both the bacteria and the drug need to be in the same place at the same time." C.H. Nightingale and colleagues from Hartford Hospital wrote, "The pharmacodynamics of antibiotics, measured as the ratio of area under the concentration-time curve:minimum inhibitory concentration (AUC:MIC), the ratio of plasma concentration:MIC, or time above MIC, indexes the pharmacokinetic properties of an antibiotic (in vivo) to a measure of microbiologic...
Source: Pharma Business Week (2006-02-27)
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