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Cancer Vaccines
Researchers describe findings in cancer vaccines studies
February 27th, 2006
Cancer vaccines research advances have been reported from Austria, Switzerland and the United Kingdom. Study 1: Density of carbohydrate epitopes on the carrier affects memory IgG immune responses. According to recent research published in the journal Bioconjugate Chemistry, "Carbohydrate antigens resulting from aberrant glycosylation of tumor cells, such as SialylTn, represent attractive targets for cancer vaccination. However, T-cell-independent carbohydrate antigens are poorly immunogenic and fail to induce memory and IgG class switch. Clustered expression patterns of some carbohydrates on the cell surface add further complexity to the...
Source: Pharma Business Week (2006-02-27)
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