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Central Nervous System
Glutamate receptor agonist may be an effective tool for investigating stress-related CNS disorders
February 27th, 2006
A selective glutamate receptor agonist may be an effective tool for investigating stress-related CNS disorders. "Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS," scientists in Switzerland report. K. Mitsukawa and colleagues from Novartis Pharma AG, wrote "These receptors consist of two domains, an extracellular region containing the orthosteric agonist site and a transmembrane heptahelical domain involved in G protein activation and recognition of several recently synthesized pharmacological modulators "The presynaptic receptor...
Source: Pharma Business Week (2006-02-27)
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