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Karolinska Institute

 Enterococcus enriched with surface protein gene show increased adhesion

Published in Pharma Investments, Ventures and Law Weekly, January 12th, 2004

Bloodstream isolates of Enterococcus faecium enriched with the enterococcal surface protein gene, esp, show increased adhesion to eukaryotic cells.

"Infection-derived Enterococcus faecium strains enriched with esp had increased ability to adhere to Caco-2 cells (p<0.05) and were less genetically diverse than esp-negative isolates," scientists in Sweden report.

"esp-Negative E. faecium fecal isolates from healthy individuals adhered significantly better than esp-negative infection isolates (p<0.05), indicating additional factors of importance to adhesion," said Bodil Lund and Charlotta Edlund at the Karolinska Institutet in...

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