Susan Hasty, Publisher
Table of Contents . . . June 6th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Pharma Investments, Ventures and Law Weekly | Other Publications
4SC AG - Agreement signed to develop compounds for autoimmune disorders
A.P. Pharma, Inc. - Pharmaceutical firm files shelf registration statement
AVI BioPharma, Inc. - Pharmaceutical company reports loss of $0.21 per share
Accredo Health, Inc. - Pharmacy provider reports earnings of $0.43 per share
Acologix, Inc. - Biopharmaceutical firm closes $40M series B financing
Acusphere, Inc. - Pharmaceutical company reports financial results, clinical update
Alpharma, Inc. - Pharmaceutical company reports loss of $0.06 per share
Arrowhead Research Corp. - Majority investment made in new nanotech subsidiary
BioLineRx Ltd. - Drug development company announces founding investors
Biovail Corporation - Pharmaceutical company reports earnings of $0.13 per share
Bristol-Myers Squibb Company - Pharmaceutical company reports $0.49 per share earnings
Caraco Pharmaceutical Laboratories - Pharmaceutical company posts first quarter net sales of $13.6M
Cell Genesys, Inc. - Oncology company reports loss of $0.47 per share
Chronimed, Inc. - Pharmaceutical distributor reports record revenues
Commonwealth Biotechnologies, Inc. - Biotech research firm posts profitable first quarter
AGA Medical Corporation - FDA clearance granted for Amplatzer Vascular Plug
Abbott Laboratories - Mammalian target of rapamycin regulates IRS-1 serine phosphorylation
Academic Medical Center, Amsterdam - Rab6 membrane association dependent on cellular phosphorylation events
Advanced Biotherapy, Inc. - Agreement signed for humanized antibody to interferon-gamma
Aerogen, Inc. - Device firm announces ISO 13485:2003 certification
Age-Related Macular Degeneration - Patient enrollment launched for age-related macular degeneration study
American Health Foundation - New data show how 6-nitrochrysene shapes mammary carcinogenesis and mutagenesis
Auckland Hospital - Changing IVIG preparations increases risk of adverse effects
Australian National University - Vaccinia virus encoding T-cell chemoattractant is attenuated in vivo
Aventis Pasteur France - Group B meningococcal vaccine safe but not effective in men
Bavarian Nordic A/S - Imvamune smallpox vaccine clinical study to include eczema patients
Biomedical Center, Upsala - Increased islet mass is linked to decreased islet blood flow during pregnancy
Brandeis University - Pediatric dengue vaccine is cost-effective
Burnham Institute - Beta-catenin regulates the gene of unique novel matrix metalloproteinase-26
Business Investigation - Cardinal Health says SEC probe now formal inquiry
Business Update - Four agencies sue Rhode Island health department over reimbursements
Business Update - HealthSouth, bondholders reach deals on debt
CHU Center Ville, Leige - "User-friendly" scoring index for clinical use identifies risk of bone loss
Centers for Disease Control & Prevention - Methods for ranking cities by public health criteria reported
Centre Hospitalier de Tourcoing - Cost-effectiveness analyses needed to evaluate HIV/AIDS prevention and care
Centre National de la Recherche Scientifique - Expression of thyroid hormone receptor isoforms in the oligodendrocyte lineage
Cerus Corporation - Scientific advisory board for therapeutic vaccine development announced
Cervical Cancer - WHO agency confirms efficacy of screening women 25-65 to reduce mortality
Chia Nan University of Pharmacy & Science - DNA dry powder for non-viral gene delivery prepared by freeze-drying
Chimerix, Inc. - Patent granted for CMX001, an orally-active smallpox therapeutic
Chlamydia - Prevalence of chlamydial infection high among young adults in U.S.
Cloning - Effort to outlaw cloning of human cells stalls in Louisiana House
CombinatoRx - Immtech inks agreement to test DB289 and DB75 as potential cancer treatment
Cornell University - Activity of Cdc42 as signaling switch reviewed
Cornell University - Structure helps explain ionotropic glutamate receptor function
Cornell University - Tyrosine-mediated inhibitory signals contribute to CTLA-4 function
Cutting Edge Information - Linking R&D and commercialization is vital to drug launch success
Cutting Edge Information - Study: Market research teams comprise 18% of total pharma marketing budgets
CyDex, Inc. - Study shows potential of new asthma formulation using Captisol
DiaSys Corporation - New urine centrifuge tube developed
Edwards Lifesciences Corporation - First U.S. implant of heart valve with ThermaFix tissue process performed
Eli Lilly and Co. - Isis announces extension of antisense cancer drug-discovery collaboration
Eli Lilly and Company - Symbyax reduces suicidal ideation symptoms in bipolar depression, studies show
Emergency Medicine - EDs see dramatic increase in people with mental illness seeking care
Emory University - Pandemic influenza can be contained with antiviral agents
Endovasc, Inc. - Stent makers announce board and officer appointees
Erasmus University - Radiolabeled peptides rise to the challenge in the face of cancer
FIND/SVP, Inc. - Survey finds 78% of consumers are interested in new types of home test kits
Flanders Interuniversity Institute for Biotechnolo - Heat shock proteins discovered to cause neurological disease
Forest Laboratories, Inc. - Data highlight positive effect of Namenda on brain activity in AD patients
Forsyth Institute - Gingipain adhesin mediates Porphyromonas gingivalis adherence
Fred Hutchinson Cancer Research Center - Allogeneic bone marrow transplantation can cure myelodysplastic syndrome
GKT School of Medicine, London - Vasopressin release reduced in ovariectomy restored by oestradiol replacement
Germans Trias i Pujol University Hospital - Nicotenic AChR subunit transcription in thymus characterized
Gifu University, Tsukasa - Nurse cell cytoplasm differs between two Trichinella species
Glasgow Royal Infirmary - Multiple trials in Europe are studying optimum statin therapy regimens
GlaxoSmithKline - Long-term treatment with Lamictal not associated with significant weight gain
Harman International - Workplace-based training program helps employees understand abuse
Harvard Bioscience, Inc. - Genomics company reports "disappointing" first quarter results
Harvard University - Transdermal drug delivery accomplished with pressure wave
Helix BioMedix, Inc. - Peptide-focused biotech closes $2.37 million financing
Hellenic Pasteur Institute, Athens - Role of CD8 cells in visceral leishmaniasis clarified
Holstebro Hospital, Denmark - Laparoscopic ovarian drilling: Effective first-line treatment for PCOS patients
Hospital Robert Ballanger, Aulnay Sous Bois - Researchers discuss valvular heart disease in 2003
Humboldt University - Anti-TIRC7 mAb prevents graft rejection in mice
IMPATH Inc. - Reorganization culminates in sale of division
INSERM U360, Paris - Prion diseases provide insights on brain targeting
INSERM U375 - Carrier cells mediate the transfer of oncolytic parvovirus to metastatic tumors
INSERM U567, Paris - Muscle insulin receptor knockout mice provide new model diabetes study
Imperial College London - Glutamate receptor upregulates amyloid precursor protein secretion
Inamed Corporation - Botulinum toxin type A clinical development program advances
Incyte Corp., Palo Alto - Novel splice variant mRNAs from known drug target genes cloned
Indiana University - 3-D computed tomography predicts the utility of resecting periampullary cancer
Inst. Advanced Industrial Science & Tech., Tokyo - Amino acid variation and HIV-1 gp120 evolution linked with second receptor usage
Institute Pasteur - Cell envelope protein contributes to M. tuberculosis immunogenicity
Institute of Biomedical Chemistry, Moscow - Components in protein mixtures identified using MS peptide mapping
Instituto Milenio para Biologia Fundamental y Apli - Neuropeptide Y is sympathetic modulator in saphenous vein biopsies
Instituto Nacional de Ciencias Medicas y Nutricion - Soy protein affects serum insulin and reduces fatty liver in rats
Invitrogen Corp. - Revenues increase 39% for lab supplies company
Israel Institute for Biological Research - Membranal polypeptides of Bacillus anthracis identified
Janssen Pharmaceutica Products, L.P. - Risperdal Consta improves schizophrenia symptoms in study patients
Johns Hopkins University - High blood testosterone levels associated with increased prostate cancer risk
Keryx Biopharmaceuticals, Inc. - Biopharmaceuticals company discusses Q1 results, impact of ACCESS acquisition
Kings College London - Rubella in developing countries still causing blindness and deafness
Klinikum Plau am See - Fas, Fas ligand, Bcl-2 and TGF beta 2 not associated with glioma prognosis
Kyoto University - Splicing variants of novel Rnd2 effector Rapostlin induces neurite branching
Laval University - Low-fat/high-carb eating plan is not bad for "good" cholesterol
Legal Issues - Florida drug counselor sentenced in 'Sandshaker' cocaine case
Legal Issues - North Carolina Medical Society suit claims unfair practices by United Healthcare
Leiden University - c-Myc makes human melanoma cells more sensitive to apoptosis activators
Ligand Pharmaceuticals, Inc. - Pharmaceutical company reports first quarter revenues up 58%
Liverpool School of Tropical Medicine - New strategy aims to halve malaria deaths by 2010
Living Cell Technologies - Tissue involved in brain development may offer new approach to stroke treatment
Lorus Therapeutics, Inc. - Company launches colon cancer trial with GTI-2040
Los Alamos National Laboratory - Mass vaccination unnecessary in event of outbreak
Lovelace Respiratory Research Institute - Retinoic acid receptor beta methylation occurs early after carcinogen exposure
Ludwig Institute for Cancer Research - Tumor-specific antigens are encoded by gene MAGE-C2
M.C. Townsend Associates - How reliable are common lung function tests?
M.D. Anderson Cancer Center - Obesity reversed in mice by destroying blood vessels that service fat cells
M.D. Anderson Cancer Center - Optimal timing for catheter removal determined in candidemia patients
MOCON, Inc. - Company reports increased sales, decreased net income in first quarter
Maastricht University - Study in pregnant women shows PTSD symptoms not associated with neuroticism
Massachusetts General Hospital - The DF3/MUC1 promoter gives oncolytic virus a boost
Mayo Clinic - Avian influenza may be new pandemic threat
Mayo Clinic Hospital - MELD has improved survival odds for liver cancer patients awaiting transplants
MedImmune, Inc. - CFO appointed, senior executives promoted at biotech firm
MedQuest, Inc. - Imaging center operator announces record revenues for the quarter
Medarex, Inc. - Antibody-focused pharmaceutical reports $31.0 million in net losses during Q1
Medical Research Council, Cambridge - Utility of pulse rate variations for concurrent sound segregation determined
Medtronic, Inc. - William A. Hawkins named president and COO
Memorial Sloan-Kettering Cancer Center - Artificial antigen presentation reviewed
Merck - HTG announces agreement for gene expression assay technology agreement
Merck and Co., Inc. - Studies show success of Mectizan partnerships
Mergers and Acquisitions - Universal Health Services, Inc., acquires five behavioral health facilities
MicroIslet, Inc. - Diabetes-focused company announces key additions to scientific team
Mt. Sinai School of Medicine - Cancer recurrence after liver transplantation shortens survival
National Center for Genome Resources - Non-profit research institute names chief operating officer
National Cheng Kung University - Puerarin mediates beta-endorphin to reduce glucose in diabetic rats
National Chiayi University - Site-directed mutagenesis of conserved residues in Bacillus reported
National Higashi-Utsunomiya Hospital - Preliminary optimal indication for nateglinide released
Necker Hospital, Paris - Immunonephelometric FLC test useful for monitoring monoclonal gammopathies
New Jersey Medical School - Exercise lowers the body weight gain and adiposity in obese rats
Norwegian Radium Hospital - Contrast-enhanced MRI reveals iron oxide particle uptake by melanoma cells
NovaDel Pharma, Inc. - Third foreign patent issued for drug delivery technology
Novare Surgical Systems, Inc. - International distribution pact signed for cardiac surgery device
Novartis Pharmaceuticals Corp. - Alex Gorsky appointed chief operating officer at pharmaceutical company
Nutra Pharma Corp. - ReceptoPharm completes HIV in-vitro studies at two universities
Nuvelo Inc. - TAFA genes have restricted expression in the brain
OSI Pharmaceuticals, Inc. - Oncology drug maker continues investment in diabetes subsidiary
OraSure Technologies, Inc. - Drug testing system launched in Europe
Oregon Health & Science University - Cholecystokinin-mediated suppression of feeding involves melanocortin
Oregon Health & Science University - Researcher finds genetic explanations for some previously unexplained deaths
Paul Ehrlich Institute, Langen - Hyaluronan-binding protease stops cytokine-driven endothelial cell growth
Pfizer Inc - Pharmaceutical company to sell manufacturing facility in Puerto Rico
Physiometrix, Inc. - Medical product manufacturer announces first quarter financial results
Prefectural University of Kumamoto - Dietary protein modulates effect of CLA on lipid metabolism in rats
Progenics Pharmaceuticals, Inc. - Biopharmaceutical company begins clinical trials of novel HIV therapy
Purdue University - Aluminum hydroxide microenvironment pH affects antigen stability
Ranbaxy USA Inc. - Pharmaceutical company appoints new medical director
Royal College of Surgeons, Dublin - Coated aspirin less effective for anticlotting than uncoated aspirin
Royal Free Hospital - Most patients still want doctors to wear white coats
Royal Free and University College Medical School - Role of therapeutic vaccines for the control of HIV-1 reviewed
Rutgers State University - Body weight and cigarette prices affect adolescent smoking
SRD Pharmaceuticals, Inc. - Pharmaceutical company acquires drug patents for novel AIDS treatment
Santa Maria Clinic, Bari - Levosimendan improves low-output heart failure after cardiac surgery
Slovak Academy of Sciences - Microenvironmental factors encourage carbonic anhydrase IX expression in tumors
Stanford University School of Medicine - Ultraviolet light exposure prevents graft-versus-host disease in animal study
TNO Human Factors Institute - Trial found no impact of Malarone on performance and alertness tasks
Taiho Pharmaceutical Co., Ltd. - Protein kinase C activation by H. pylori limits IL-8 production
Tarpan Therapeutics, Inc. - IGI signs a sublicense agreement related to Novasome delivery technology
Theratechnologies - Positive preliminary phase I results announced for osteoporosis treatment
ThermoGenesis Corp. - CryoSeal FS System receives Japanese patent
Tokyo Institute of Psychiatry - Japanese girls' attitudes to eating disorders vary with age, knowledge
Toyama Medical & Pharmaceutical Univ. - Enhanced iNOS expression associated with progression of CAL in Kawasaki disease
Tulane University - Teens teaching teens about safer sex is African success story
Tyco International Ltd. - Diversified company reports second quarter earnings of $0.37 per share
U.S. Agency for Healthcare Res. & Quality - Screening guidelines for coronary heart disease are updated
U.S. Food & Drug Administration - Gene probes for quantifying Vibrio in crabmeat evaluated
U.S. Food and Drug Administration - FDA to determine health significance of low furan levels in foods
U.S. National Cancer Institute - No link found between IGF or IGF-binding protein and pancreatic cancer
U.S. National Institutes of Health - Antioxidant corrects neurobehavioral defect in ataxia-telangiectasia
U.S. National Institutes of Health - Reference materials program for dietary supplements outlined
Uludag University - Full-thickness skin graft is efficient for vaginal construction
Univ. of California San Francisco - Trypsin IV is a novel agonist of protease-activated receptors 2 and 4
Univ. of California, Los Angeles - CTL ontogeny and viral escape have implications for HIV vaccine design
Univ. of California, Los Angeles - New "designer" steroid discovered in anonymously provided syringe
Univ. of California, San Francisco - Hepatitis C virus may be a diabetes trigger in liver transplant recipients
Univ. of Illinois, Chicago - Clerks control healthcare access for uninsured patients, study finds
Univ. of Pittsburgh - Condition's symptoms adversely affect sexual activity of women
Univ. of Texas Medical Branch - Fc-dependent antibodies protect mice against Rickettsia conorii
Univ. of Wales College of Medicine - Sentinel node biopsy accurately stages axilla in multifocal breast cancer
Universidad Nacional de Colombia - Plasmodium falciparum peptides bind to human hepatocytes
Universidade Federal do Rio Grande do Norte - Leishmaniasis in Brazil is a disease of urban-rural interface
Universiti Sains Malaysia - Cytokine gene expression in diabetes pathogenesis discussed
University General Hospital, Murcia - New method described to localize nonpalpable lesions with adhesive marker plate
University Hospital Groningen - More stringent infection control measures called for
University of Alabama - L-Arginine inhibits endothelial dysfunction in hypercholesterolemia
University of Amsterdam - A new system shows adenoviruses elicit poor transduction in esophageal cancer
University of Birmingham - MMR vaccine controversy offers insights into health risk communication
University of Buenos Aires - Oxidative stress in hypertensive rat livers decreases after diabetes
University of Catania - The new asbestos amphibole fluoro-edenite is linked to Italian cancer cases
University of Copenhagen - NanoChip SNP typing protocol provides accurate results
University of Edinburgh - Diagnostic value of heart fatty-acid-binding protein reviewed
University of Edinburgh - Major form of MeCP2 has N-terminus generated by alternative splicing
University of Georgia - Method for assigning protein backbone NMR resonances reported
University of Hawaii - Common cancers prevail among first-degree relatives of ovarian cancer patients
University of Illinois, Chicago - Program improves physical fitness in adults with Down syndrome
University of Leeds - Genes to be "flipped" for drug-free treatment
University of Melbourne - Platelet-derived growth factor halts the biomechanics of ischemic eye disease
University of Miami - Neointestinal cysts found after intestinal epithelium organoid implantation
University of Michigan - Aerobic exercise may attenuate age-related decline in protein synthesis
University of Michigan - Chronic respiratory symptoms prevalent among Alaska natives
University of Michigan - Disease management program may improve student grades, decrease absences
University of Michigan - Molecular markers may be able to predict risk of recurrent prostate cancer
University of Michigan - PSA doubling time sheds light on hormone refractory prostate cancer
University of Milan - Doxorubicin engenders paradoxical signals in the heart
University of Milan - Dual HHV8 and HCV infection induced Kaposi sarcoma in a female patient
University of Mississippi - Novel hLAMP-1 clones should facilitate study
University of North Texas - Estrogen receptor beta localized to mitochondria
University of Oslo - Cyclic peptides that bind to meningococcal LPS antibody characterized
University of Otago - Dendritic cell vaccine efficacy quantified using flow cytometry
University of Oulu - Combination BMD + upper femur geometry improves hip fracture prediction
University of Pennsylvania - Gastroenterology residents should receive diagnostic laparoscopy training
University of Pennsylvania - Minimal residual breast cancer detected using CK19 and EGF-R primers in RT-PCR
University of Perugia - GITR costimulates murine T-cell subpopulations
University of Pisa - Innovative tissue engineering structure powerful means to study cell response
University of Regensburg - E. coli strain Nissle 1917 prevents intestinal inflammation
University of Rome 'La Sapienza' - Origin of lateral costal artery investigated
University of Rostock - Astrocytes have neuroprotective role during inflammation
University of Sao Paulo - Myocardial performance index tracks hypertrophy development
University of Surrey - Young women in U.K. have lower incidence of ischemic stroke than U.S., Europe
University of Tennessee - Phosphorylated proteins in human pituitary characterized
University of Vienna - Safety and efficacy of pimecrolimus reviewed
University of Wales - Vaccination against cervical cancer reviewed
University of Washington - Human herpesvirus-8 oral shedding higher without antiretroviral therapy
University of Wisconsin-Madison - Smokers welcome help in quitting when offered at clinic visits
University of the Basque Country - Blastocyst-derived cell is source of neural derivates for differentiation study
Vanderbilt University School of Medicine - Data: ZOMIG (zolmitriptan) nasal spray provides fast, lasting migraine relief
Vicuron Pharmaceuticals Inc. - Anidulafungin most potent when compared to other antifungal agents, study shows
Warmia-Masuria University - Anisakis simplex larvae reduce pepsin activity after infection
Yale University - A1 adenosine receptors mediate hypoglycemia-induced neuronal injury
Yale University - Apoptosis of vasopressinergic hypothalamic neurons occurs in diabetes
etrials Worldwide, Inc. - Interactive voice response and clinical trial management technology acquired
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