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Pharma Investments, Ventures and Law Weekly

Susan Hasty, Publisher

Table of Contents . . . June 6th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pharma Investments, Ventures and Law Weekly | Other Publications

4SC AG - Agreement signed to develop compounds for autoimmune disorders

A.P. Pharma, Inc. - Pharmaceutical firm files shelf registration statement

AVI BioPharma, Inc. - Pharmaceutical company reports loss of $0.21 per share

Accredo Health, Inc. - Pharmacy provider reports earnings of $0.43 per share

Acologix, Inc. - Biopharmaceutical firm closes $40M series B financing

Acusphere, Inc. - Pharmaceutical company reports financial results, clinical update

Alpharma, Inc. - Pharmaceutical company reports loss of $0.06 per share

Arrowhead Research Corp. - Majority investment made in new nanotech subsidiary

BioLineRx Ltd. - Drug development company announces founding investors

Biovail Corporation - Pharmaceutical company reports earnings of $0.13 per share

Bristol-Myers Squibb Company - Pharmaceutical company reports $0.49 per share earnings

Caraco Pharmaceutical Laboratories - Pharmaceutical company posts first quarter net sales of $13.6M

Cell Genesys, Inc. - Oncology company reports loss of $0.47 per share

Chronimed, Inc. - Pharmaceutical distributor reports record revenues

Commonwealth Biotechnologies, Inc. - Biotech research firm posts profitable first quarter

AGA Medical Corporation - FDA clearance granted for Amplatzer Vascular Plug

Abbott Laboratories - Mammalian target of rapamycin regulates IRS-1 serine phosphorylation

Academic Medical Center, Amsterdam - Rab6 membrane association dependent on cellular phosphorylation events

Advanced Biotherapy, Inc. - Agreement signed for humanized antibody to interferon-gamma

Aerogen, Inc. - Device firm announces ISO 13485:2003 certification

Age-Related Macular Degeneration - Patient enrollment launched for age-related macular degeneration study

American Health Foundation - New data show how 6-nitrochrysene shapes mammary carcinogenesis and mutagenesis

Auckland Hospital - Changing IVIG preparations increases risk of adverse effects

Australian National University - Vaccinia virus encoding T-cell chemoattractant is attenuated in vivo

Aventis Pasteur France - Group B meningococcal vaccine safe but not effective in men

Bavarian Nordic A/S - Imvamune smallpox vaccine clinical study to include eczema patients

Biomedical Center, Upsala - Increased islet mass is linked to decreased islet blood flow during pregnancy

Brandeis University - Pediatric dengue vaccine is cost-effective

Burnham Institute - Beta-catenin regulates the gene of unique novel matrix metalloproteinase-26

Business Investigation - Cardinal Health says SEC probe now formal inquiry

Business Update - Four agencies sue Rhode Island health department over reimbursements

Business Update - HealthSouth, bondholders reach deals on debt

CHU Center Ville, Leige - "User-friendly" scoring index for clinical use identifies risk of bone loss

Centers for Disease Control & Prevention - Methods for ranking cities by public health criteria reported

Centre Hospitalier de Tourcoing - Cost-effectiveness analyses needed to evaluate HIV/AIDS prevention and care

Centre National de la Recherche Scientifique - Expression of thyroid hormone receptor isoforms in the oligodendrocyte lineage

Cerus Corporation - Scientific advisory board for therapeutic vaccine development announced

Cervical Cancer - WHO agency confirms efficacy of screening women 25-65 to reduce mortality

Chia Nan University of Pharmacy & Science - DNA dry powder for non-viral gene delivery prepared by freeze-drying

Chimerix, Inc. - Patent granted for CMX001, an orally-active smallpox therapeutic

Chlamydia - Prevalence of chlamydial infection high among young adults in U.S.

Cloning - Effort to outlaw cloning of human cells stalls in Louisiana House

CombinatoRx - Immtech inks agreement to test DB289 and DB75 as potential cancer treatment

Cornell University - Activity of Cdc42 as signaling switch reviewed

Cornell University - Structure helps explain ionotropic glutamate receptor function

Cornell University - Tyrosine-mediated inhibitory signals contribute to CTLA-4 function

Cutting Edge Information - Linking R&D and commercialization is vital to drug launch success

Cutting Edge Information - Study: Market research teams comprise 18% of total pharma marketing budgets

CyDex, Inc. - Study shows potential of new asthma formulation using Captisol

DiaSys Corporation - New urine centrifuge tube developed

Edwards Lifesciences Corporation - First U.S. implant of heart valve with ThermaFix tissue process performed

Eli Lilly and Co. - Isis announces extension of antisense cancer drug-discovery collaboration

Eli Lilly and Company - Symbyax reduces suicidal ideation symptoms in bipolar depression, studies show

Emergency Medicine - EDs see dramatic increase in people with mental illness seeking care

Emory University - Pandemic influenza can be contained with antiviral agents

Endovasc, Inc. - Stent makers announce board and officer appointees

Erasmus University - Radiolabeled peptides rise to the challenge in the face of cancer

FIND/SVP, Inc. - Survey finds 78% of consumers are interested in new types of home test kits

Flanders Interuniversity Institute for Biotechnolo - Heat shock proteins discovered to cause neurological disease

Forest Laboratories, Inc. - Data highlight positive effect of Namenda on brain activity in AD patients

Forsyth Institute - Gingipain adhesin mediates Porphyromonas gingivalis adherence

Fred Hutchinson Cancer Research Center - Allogeneic bone marrow transplantation can cure myelodysplastic syndrome

GKT School of Medicine, London - Vasopressin release reduced in ovariectomy restored by oestradiol replacement

Germans Trias i Pujol University Hospital - Nicotenic AChR subunit transcription in thymus characterized

Gifu University, Tsukasa - Nurse cell cytoplasm differs between two Trichinella species

Glasgow Royal Infirmary - Multiple trials in Europe are studying optimum statin therapy regimens

GlaxoSmithKline - Long-term treatment with Lamictal not associated with significant weight gain

Harman International - Workplace-based training program helps employees understand abuse

Harvard Bioscience, Inc. - Genomics company reports "disappointing" first quarter results

Harvard University - Transdermal drug delivery accomplished with pressure wave

Helix BioMedix, Inc. - Peptide-focused biotech closes $2.37 million financing

Hellenic Pasteur Institute, Athens - Role of CD8 cells in visceral leishmaniasis clarified

Holstebro Hospital, Denmark - Laparoscopic ovarian drilling: Effective first-line treatment for PCOS patients

Hospital Robert Ballanger, Aulnay Sous Bois - Researchers discuss valvular heart disease in 2003

Humboldt University - Anti-TIRC7 mAb prevents graft rejection in mice

IMPATH Inc. - Reorganization culminates in sale of division

INSERM U360, Paris - Prion diseases provide insights on brain targeting

INSERM U375 - Carrier cells mediate the transfer of oncolytic parvovirus to metastatic tumors

INSERM U567, Paris - Muscle insulin receptor knockout mice provide new model diabetes study

Imperial College London - Glutamate receptor upregulates amyloid precursor protein secretion

Inamed Corporation - Botulinum toxin type A clinical development program advances

Incyte Corp., Palo Alto - Novel splice variant mRNAs from known drug target genes cloned

Indiana University - 3-D computed tomography predicts the utility of resecting periampullary cancer

Inst. Advanced Industrial Science & Tech., Tokyo - Amino acid variation and HIV-1 gp120 evolution linked with second receptor usage

Institute Pasteur - Cell envelope protein contributes to M. tuberculosis immunogenicity

Institute of Biomedical Chemistry, Moscow - Components in protein mixtures identified using MS peptide mapping

Instituto Milenio para Biologia Fundamental y Apli - Neuropeptide Y is sympathetic modulator in saphenous vein biopsies

Instituto Nacional de Ciencias Medicas y Nutricion - Soy protein affects serum insulin and reduces fatty liver in rats

Invitrogen Corp. - Revenues increase 39% for lab supplies company

Israel Institute for Biological Research - Membranal polypeptides of Bacillus anthracis identified

Janssen Pharmaceutica Products, L.P. - Risperdal Consta improves schizophrenia symptoms in study patients

Johns Hopkins University - High blood testosterone levels associated with increased prostate cancer risk

Keryx Biopharmaceuticals, Inc. - Biopharmaceuticals company discusses Q1 results, impact of ACCESS acquisition

Kings College London - Rubella in developing countries still causing blindness and deafness

Klinikum Plau am See - Fas, Fas ligand, Bcl-2 and TGF beta 2 not associated with glioma prognosis

Kyoto University - Splicing variants of novel Rnd2 effector Rapostlin induces neurite branching

Laval University - Low-fat/high-carb eating plan is not bad for "good" cholesterol

Legal Issues - Florida drug counselor sentenced in 'Sandshaker' cocaine case

Legal Issues - North Carolina Medical Society suit claims unfair practices by United Healthcare

Leiden University - c-Myc makes human melanoma cells more sensitive to apoptosis activators

Ligand Pharmaceuticals, Inc. - Pharmaceutical company reports first quarter revenues up 58%

Liverpool School of Tropical Medicine - New strategy aims to halve malaria deaths by 2010

Living Cell Technologies - Tissue involved in brain development may offer new approach to stroke treatment

Lorus Therapeutics, Inc. - Company launches colon cancer trial with GTI-2040

Los Alamos National Laboratory - Mass vaccination unnecessary in event of outbreak

Lovelace Respiratory Research Institute - Retinoic acid receptor beta methylation occurs early after carcinogen exposure

Ludwig Institute for Cancer Research - Tumor-specific antigens are encoded by gene MAGE-C2

M.C. Townsend Associates - How reliable are common lung function tests?

M.D. Anderson Cancer Center - Obesity reversed in mice by destroying blood vessels that service fat cells

M.D. Anderson Cancer Center - Optimal timing for catheter removal determined in candidemia patients

MOCON, Inc. - Company reports increased sales, decreased net income in first quarter

Maastricht University - Study in pregnant women shows PTSD symptoms not associated with neuroticism

Massachusetts General Hospital - The DF3/MUC1 promoter gives oncolytic virus a boost

Mayo Clinic - Avian influenza may be new pandemic threat

Mayo Clinic Hospital - MELD has improved survival odds for liver cancer patients awaiting transplants

MedImmune, Inc. - CFO appointed, senior executives promoted at biotech firm

MedQuest, Inc. - Imaging center operator announces record revenues for the quarter

Medarex, Inc. - Antibody-focused pharmaceutical reports $31.0 million in net losses during Q1

Medical Research Council, Cambridge - Utility of pulse rate variations for concurrent sound segregation determined

Medtronic, Inc. - William A. Hawkins named president and COO

Memorial Sloan-Kettering Cancer Center - Artificial antigen presentation reviewed

Merck - HTG announces agreement for gene expression assay technology agreement

Merck and Co., Inc. - Studies show success of Mectizan partnerships

Mergers and Acquisitions - Universal Health Services, Inc., acquires five behavioral health facilities

MicroIslet, Inc. - Diabetes-focused company announces key additions to scientific team

Mt. Sinai School of Medicine - Cancer recurrence after liver transplantation shortens survival

National Center for Genome Resources - Non-profit research institute names chief operating officer

National Cheng Kung University - Puerarin mediates beta-endorphin to reduce glucose in diabetic rats

National Chiayi University - Site-directed mutagenesis of conserved residues in Bacillus reported

National Higashi-Utsunomiya Hospital - Preliminary optimal indication for nateglinide released

Necker Hospital, Paris - Immunonephelometric FLC test useful for monitoring monoclonal gammopathies

New Jersey Medical School - Exercise lowers the body weight gain and adiposity in obese rats

Norwegian Radium Hospital - Contrast-enhanced MRI reveals iron oxide particle uptake by melanoma cells

NovaDel Pharma, Inc. - Third foreign patent issued for drug delivery technology

Novare Surgical Systems, Inc. - International distribution pact signed for cardiac surgery device

Novartis Pharmaceuticals Corp. - Alex Gorsky appointed chief operating officer at pharmaceutical company

Nutra Pharma Corp. - ReceptoPharm completes HIV in-vitro studies at two universities

Nuvelo Inc. - TAFA genes have restricted expression in the brain

OSI Pharmaceuticals, Inc. - Oncology drug maker continues investment in diabetes subsidiary

OraSure Technologies, Inc. - Drug testing system launched in Europe

Oregon Health & Science University - Cholecystokinin-mediated suppression of feeding involves melanocortin

Oregon Health & Science University - Researcher finds genetic explanations for some previously unexplained deaths

Paul Ehrlich Institute, Langen - Hyaluronan-binding protease stops cytokine-driven endothelial cell growth

Pfizer Inc - Pharmaceutical company to sell manufacturing facility in Puerto Rico

Physiometrix, Inc. - Medical product manufacturer announces first quarter financial results

Prefectural University of Kumamoto - Dietary protein modulates effect of CLA on lipid metabolism in rats

Progenics Pharmaceuticals, Inc. - Biopharmaceutical company begins clinical trials of novel HIV therapy

Purdue University - Aluminum hydroxide microenvironment pH affects antigen stability

Ranbaxy USA Inc. - Pharmaceutical company appoints new medical director

Royal College of Surgeons, Dublin - Coated aspirin less effective for anticlotting than uncoated aspirin

Royal Free Hospital - Most patients still want doctors to wear white coats

Royal Free and University College Medical School - Role of therapeutic vaccines for the control of HIV-1 reviewed

Rutgers State University - Body weight and cigarette prices affect adolescent smoking

SRD Pharmaceuticals, Inc. - Pharmaceutical company acquires drug patents for novel AIDS treatment

Santa Maria Clinic, Bari - Levosimendan improves low-output heart failure after cardiac surgery

Slovak Academy of Sciences - Microenvironmental factors encourage carbonic anhydrase IX expression in tumors

Stanford University School of Medicine - Ultraviolet light exposure prevents graft-versus-host disease in animal study

TNO Human Factors Institute - Trial found no impact of Malarone on performance and alertness tasks

Taiho Pharmaceutical Co., Ltd. - Protein kinase C activation by H. pylori limits IL-8 production

Tarpan Therapeutics, Inc. - IGI signs a sublicense agreement related to Novasome delivery technology

Theratechnologies - Positive preliminary phase I results announced for osteoporosis treatment

ThermoGenesis Corp. - CryoSeal FS System receives Japanese patent

Tokyo Institute of Psychiatry - Japanese girls' attitudes to eating disorders vary with age, knowledge

Toyama Medical & Pharmaceutical Univ. - Enhanced iNOS expression associated with progression of CAL in Kawasaki disease

Tulane University - Teens teaching teens about safer sex is African success story

Tyco International Ltd. - Diversified company reports second quarter earnings of $0.37 per share

U.S. Agency for Healthcare Res. & Quality - Screening guidelines for coronary heart disease are updated

U.S. Food & Drug Administration - Gene probes for quantifying Vibrio in crabmeat evaluated

U.S. Food and Drug Administration - FDA to determine health significance of low furan levels in foods

U.S. National Cancer Institute - No link found between IGF or IGF-binding protein and pancreatic cancer

U.S. National Institutes of Health - Antioxidant corrects neurobehavioral defect in ataxia-telangiectasia

U.S. National Institutes of Health - Reference materials program for dietary supplements outlined

Uludag University - Full-thickness skin graft is efficient for vaginal construction

Univ. of California San Francisco - Trypsin IV is a novel agonist of protease-activated receptors 2 and 4

Univ. of California, Los Angeles - CTL ontogeny and viral escape have implications for HIV vaccine design

Univ. of California, Los Angeles - New "designer" steroid discovered in anonymously provided syringe

Univ. of California, San Francisco - Hepatitis C virus may be a diabetes trigger in liver transplant recipients

Univ. of Illinois, Chicago - Clerks control healthcare access for uninsured patients, study finds

Univ. of Pittsburgh - Condition's symptoms adversely affect sexual activity of women

Univ. of Texas Medical Branch - Fc-dependent antibodies protect mice against Rickettsia conorii

Univ. of Wales College of Medicine - Sentinel node biopsy accurately stages axilla in multifocal breast cancer

Universidad Nacional de Colombia -  Plasmodium falciparum peptides bind to human hepatocytes

Universidade Federal do Rio Grande do Norte - Leishmaniasis in Brazil is a disease of urban-rural interface

Universiti Sains Malaysia - Cytokine gene expression in diabetes pathogenesis discussed

University General Hospital, Murcia - New method described to localize nonpalpable lesions with adhesive marker plate

University Hospital Groningen - More stringent infection control measures called for

University of Alabama - L-Arginine inhibits endothelial dysfunction in hypercholesterolemia

University of Amsterdam - A new system shows adenoviruses elicit poor transduction in esophageal cancer

University of Birmingham - MMR vaccine controversy offers insights into health risk communication

University of Buenos Aires - Oxidative stress in hypertensive rat livers decreases after diabetes

University of Catania - The new asbestos amphibole fluoro-edenite is linked to Italian cancer cases

University of Copenhagen - NanoChip SNP typing protocol provides accurate results

University of Edinburgh - Diagnostic value of heart fatty-acid-binding protein reviewed

University of Edinburgh - Major form of MeCP2 has N-terminus generated by alternative splicing

University of Georgia - Method for assigning protein backbone NMR resonances reported

University of Hawaii - Common cancers prevail among first-degree relatives of ovarian cancer patients

University of Illinois, Chicago - Program improves physical fitness in adults with Down syndrome

University of Leeds - Genes to be "flipped" for drug-free treatment

University of Melbourne - Platelet-derived growth factor halts the biomechanics of ischemic eye disease

University of Miami - Neointestinal cysts found after intestinal epithelium organoid implantation

University of Michigan - Aerobic exercise may attenuate age-related decline in protein synthesis

University of Michigan - Chronic respiratory symptoms prevalent among Alaska natives

University of Michigan - Disease management program may improve student grades, decrease absences

University of Michigan - Molecular markers may be able to predict risk of recurrent prostate cancer

University of Michigan - PSA doubling time sheds light on hormone refractory prostate cancer

University of Milan - Doxorubicin engenders paradoxical signals in the heart

University of Milan - Dual HHV8 and HCV infection induced Kaposi sarcoma in a female patient

University of Mississippi - Novel hLAMP-1 clones should facilitate study

University of North Texas - Estrogen receptor beta localized to mitochondria

University of Oslo - Cyclic peptides that bind to meningococcal LPS antibody characterized

University of Otago - Dendritic cell vaccine efficacy quantified using flow cytometry

University of Oulu - Combination BMD + upper femur geometry improves hip fracture prediction

University of Pennsylvania - Gastroenterology residents should receive diagnostic laparoscopy training

University of Pennsylvania - Minimal residual breast cancer detected using CK19 and EGF-R primers in RT-PCR

University of Perugia - GITR costimulates murine T-cell subpopulations

University of Pisa - Innovative tissue engineering structure powerful means to study cell response

University of Regensburg -  E. coli strain Nissle 1917 prevents intestinal inflammation

University of Rome 'La Sapienza' - Origin of lateral costal artery investigated

University of Rostock - Astrocytes have neuroprotective role during inflammation

University of Sao Paulo - Myocardial performance index tracks hypertrophy development

University of Surrey - Young women in U.K. have lower incidence of ischemic stroke than U.S., Europe

University of Tennessee - Phosphorylated proteins in human pituitary characterized

University of Vienna - Safety and efficacy of pimecrolimus reviewed

University of Wales - Vaccination against cervical cancer reviewed

University of Washington - Human herpesvirus-8 oral shedding higher without antiretroviral therapy

University of Wisconsin-Madison - Smokers welcome help in quitting when offered at clinic visits

University of the Basque Country - Blastocyst-derived cell is source of neural derivates for differentiation study

Vanderbilt University School of Medicine - Data: ZOMIG (zolmitriptan) nasal spray provides fast, lasting migraine relief

Vicuron Pharmaceuticals Inc. - Anidulafungin most potent when compared to other antifungal agents, study shows

Warmia-Masuria University -  Anisakis simplex larvae reduce pepsin activity after infection

Yale University - A1 adenosine receptors mediate hypoglycemia-induced neuronal injury

Yale University - Apoptosis of vasopressinergic hypothalamic neurons occurs in diabetes

etrials Worldwide, Inc. - Interactive voice response and clinical trial management technology acquired

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