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Pharma Investments, Ventures and Law Weekly

Susan Hasty, Publisher

Table of Contents . . . July 11th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pharma Investments, Ventures and Law Weekly | Other Publications

Alliance Pharmaceutical Corp. - Pharmaceutical company receives commitments for $11M financing

Alnylam Pharmaceuticals, Inc. - Biopharmaceutical firm exercises underwriters' over-allotment option

BioNumerik Pharmaceuticals, Inc. - Pharmaceutical company files for initial public offering

Biovail Corporation - Pharmaceutical company amends 2004 stock option plan proposal

CV Therapeutics, Inc. - Biopharmaceutical company sells $25M in convertible notes

Depomed, Inc. - Pharmaceutical company acquires remaining interest in subsidiary

Encysive Pharmaceuticals - Pharmaceutical company files $150M universal shelf registration statement

Finance - Affymetrix boosts earnings estimate

Finance - Rite Aid reports a 4.8% increase in same store sales for May

Kos Pharmaceuticals, Inc. - Kos obtains settlement for trademark infringement of Advicor

Labcyte, Inc. - Patents issued for acoustics to manipulate liquids

Lumenis, Ltd. - Laser maker reports preliminary first quarter revenue of $65.1 million

Memory Pharmaceuticals Corp. - Jzaneen A. Lalani named VP legal affairs

Protein Design Labs, Inc. - Therapeutics company announces executive appointments

Repligen Corporation - Biopharmaceutical company reports fourth quarter financial results

Abbott Laboratories - FDA accuses maker of antiretroviral of misleading promotions

Abgenix - Data: Panitumumab has single-agent antitumor activity in colorectal cancer

Academy Ziekenhuis Maastricht - Elective single embryo transfer percentage reflects quality of institution

Advanced Neuromodulation Systems - Neuromodulation company comments on acquisition of Advanced Bionics

Agennix Inc. - Results from phase I/II cancer trials with rhLF presented at ASCO

Allos Therapeutics, Inc. - Data from phase III trial of radiation sensitizer presented at ASCO

Alltracel Pharmaceuticals Plc - Biotech company announces entry into European surgical devices market

Altea Therapeutics - Insulin patch maker expands its capabilities with new directors

American Academy of Allergy, Asthma & Immunology - Prevalence, exposure to mouse allergen may contribute to asthma

American Diabetes Association - Report: Islet cell transplant program for type 1 diabetes successful

American Society of Clinical Oncology - NSABP protocol C-06: Oral chemotherapy equally effective and tolerated

American Society of Neuroradiology - Advancements in imaging enhance diagnosis, treatment of neurological diseases

Antoine Beclere Hospital - Severe infections plague acute alcoholic hepatitis patients given infliximab

Aphton - Regulatory submission of pancreatic cancer therapy begins in Switzerland

Aspect Medical Systems, Inc. - Device maker announces sale of common stock to Boston Scientific

Avanir Pharmaceuticals - Anthrax antibody profiled in medical journal

BBK Healthcare, Inc. - European survey identifies need for more education surrounding clinical trials

Bayer - Diabetic men are at greater risk for developing erectile dysfunction

Baylor College of Medicine - Researchers compare two methods of diagnosing congestive heart failure

Biomol International - Study: Red wine dietary supplement may activate Sirtuin 1 gene

Biophan Technologies, Inc. - Worldwide rights acquired for MRI-safe ceramic motor

Brigham & Women's Hospital - TAMs accumulate at similar rates during ZDV or d4T treatment

California Dept. of Health Services - Fast-food beef tacos blamed for multistate E. coli outbreak

Cancer Research U.K. - Hematopoietic growth factors manage the effects of non-Hodgkin lymphoma therapy

Cancer Treatment - University of Connecticut planning to make cancer center one of nation's elite

CancerVax Corporation - Data released on Canvaxin in treatment of patients with Stage IV melanoma

Caprion Pharmaceuticals - Therapeutic antibody program acquired from Sunol Molecular

CardioTech International, Inc. - DermaPhylyx awarded "Medicare Participating Provider" status

Catholic University of the Sacred Heart, Rome - Priming with rhG-CSF enhances gemtuzumab-ozogamicin efficacy in AML

Cecil Clinic, Lausanne - Sirolimus-eluting coronary stents effective in routine clinical practice

Cel-Sci Corp. - Phase II trial results for Multikine treatment released at ASCO

Cell Genesys, Inc. - Final results of phase I/II trial of CG7870 reported

Center for Environmental Hlth, Dallas - Toxic exposure to molds and mycotoxins yield abnormal neurological functions

Centers for Disease Control & Prevention - Lessons from measles surveillance in the U.S. outlined

Centers for Disease Control & Prevention - Overall population immunity to measles in U.S. is 93%

Centro Inves Estudios Avanzados IPN, Mexico City - La protein binds to NS5 and NS3 and to 5' and 3' ends of Dengue 4 virus RNA

Chelsea & Westminster Hospital, London - HIV-related germ cell tumor not more aggressive than GCT in general population

Chembio Diagnostic Systems, Inc. - Tuberculin-boosted antibodies correlate with immunity in cattle

Complementary and Alternative Medicine - MayoClinic.com adds dietary supplements search tool

Copernicus Therapeutics, Inc. - Progress reported in development of non-viral gene transfer aerosol product

Curtin Univ. of Technology, Perth - New HIV-1 integrase inhibitors developed

Cytokinetics, Inc. - Phase I results for SB-715992 presented at ASCO

Duke University - Researchers introduce noninvasive cineangiography by MRI

Emory University - Hypoxia-inducible factor 1 alpha is expressed early in prostate malignancies

Emory University Hospital - Atrophy sets adenocarcinoma apart from pancreatic intraepithelial neoplasia

European League Against Rheumatism - Deficiencies in healthcare provision exposed

Federal University of Sao Carlos - Alternagin-C is an angiogenesis activator

Fischer Imaging Corporation - Three SenoScan systems to be installed at California-based breast center

Fred Hutchinson Cancer Research Center - Counseling improves women's functioning

Free University of Berlin - Rubral GABAergic inhibition has little effect on paroxysmal dystonia

Free University of Brussels - pH-sensitive toxins find application in vaccines and drug delivery

GTx, Inc. - Positive ACAPODENE data presented at ASCO meeting

Genentech, Inc. - Avastin, Tarceva combination yields initial promising results for cancers

Genentech, Inc. - Rituxan plus chemotherapy improves survival in aggressive NHL study patients

GenoMed, Inc. - West Nile encephalitis patients respond promptly to new treatment

Georgia Institute of Technology - The efficacy of electroporation is divergent in multicellular environments

Geospiza - Companies to offer DNA sequencing instruments, analysis software as a package

GlaxoSmithKline - Positive results released from two Bexxar studies

Global HIV Prevention Working Group - Experts: Integrate AIDS prevention and treatment to fight epidemic

Gynecologic Surgery - End-to-end cervico-cervical anastomosis is feasible if necessary

Harris Interactive - Survey: Most think drugs should be prescribed for FDA-approved uses only

Harvard University - Anal Pap smears inaccurate predictor of high-grade anal dysplasia

Harvard University - Cell surface receptor SLAM controls T-cell and macrophage activity

Harvard University - Methyltestosterone may help fight CHD in surgically postmenopausal women

Hokkaido University - Novel murine model of Hantaan virus infection developed

Hospital 12 de Octubre - Irbesartan benefits diabetic patients at any stage of renal disease

IVAX Corp. - FDA grants approval of generic Ciprofloxacin tablets

ImaRx, Inc. - Ultrasound could be used to get drugs to tumors

Indiana University - Maintenance therapy discontinuation for histoplasmosis safe after HAART response

Inex Pharmaceuticals Corporation - Epicutaneous CpG oligodeoxynucleotides with antigen promotes CTL

Institut Pasteur de Tunis -  Leishmania amastigotes induce transcription factor in macrophages

Institute Clinical & Experimental Med - Intra-abdominal fat during controlled weight reduction quantified

Institute of Human Virology - New strategies detect HIV earlier and more effectively than ever

Johns Hopkins University - Glucose sensors incorporating closed loop insulin delivery reviewed

Johns Hopkins University - Improved nutrition could prevent more than half of the world's child deaths

Juntendo University - Fyn kinase gene polymorphisms not linked to sporadic Alzheimer disease

Kagawa Nutrition University - Phycocyanin plus antigen-entrapped microparticles enhance IgA response

Keryx Biopharmaceuticals, Inc. - Company initiates phase II corporate clinical program for KRX-0401 (Perifosine)

Kos Pharmaceuticals, Inc. - New patent covers biopharmaceutical characteristics of Niaspan and Advicor

Kyoto University - Sphingomyelin synthase 1 plays a critical role in the growth of lymphoid cells

Kyungpook National University Hospital - Early absolute lymphocyte count useful prognostic marker for infection after SCT

Kyushu University of Hospital - Pemirolast is a potent reliever of paclitaxel-induced allergic reactions

M.D. Anderson Cancer Center - Manipulating master molecule disrupts vascular environment for tumors

Mardis, Aibel and Associates, LLC - Study: Common management practices can cost typical biotech company $2B

Mayo Clinic & Mayo Foundation - Rad9 protects cells from topoisomerase-mediated death

Mazor Surgical Technologies - U.S. FDA approves miniature robot for spinal procedures

McGaw Medical Center, Chicago - OC educational program for black women shows short-term success

McGill University - New target to control asthma identified

Mental Health - Communities around Pennsylvania start teen mental health screening

Merck KGaA - Trials show Erbitux provides new options for patients with colorectal cancer

Milestone Scientific, Inc. - CompuMed maker announces appointment of new auditors and election of new CFO

Moll Industries, Inc. - Medrad and plastics company extend partnership

Mount Sinai Hospital, Chicago - Increased HIV testing in underutilized venues may increase HIV status awareness

NASA Ames Research Center - Lower body negative pressure suitable for simulating gravity effects

National Public Health Institute, Finland - Environmental and dietary causes of type 1 diabetes reviewed

National Research Council Canada - Multiring radio-frequency coils suitable for MR microimaging

National Taiwan Univ. Hospital, Taipei - HBV/HIV coinfected patients increased risk for virologic failure after HAART

Netherlands Cancer Institute - BRCA1 germline carriers are at risk for more than ovarian cancer

Netherlands Cancer Institute - Oncogenic marker is a powerful prognostic tool

New York State Department of Health - Huntington disease transgenic mice exhibit early behavior abnormalities

Niigata University - Bio-Oss promotes bone formation in rats

Nuclear Policy Research Institute - Study documents dramatic increase in thyroid cancer in women and children

Nutrition 21, Inc. - Chromium supplementation may improve glucose and insulin metabolism

OSI Pharmaceuticals, Inc. - Company summarizes survival benefits in key patient subsets from BR.21 study

Ohio State University - Abnormal chromosomes forecast leukemia relapse

Osaka Bioscience Institute - ADP-ribosylation factor 6 is an integral component of breast cancer invasion

Peninsula Pharmaceuticals, Inc. - Patient enrollment begins in Doripenem trial for hospital-acquired pneumonia

Pennsylvania State University - Control of alternative sigma factor in E. coli described

Pintex Pharmaceuticals, Inc. - Pin1 enzyme may lead to development of more precise cancer treatments

Poliomyelitis - Health officials say Botswana polio campaign was wake-up call to the world

Quintiles Transnational Corp. - Drug development services provider receives CDISC certification

R2 Technology, Inc. - CAD developer names interim president and chief executive officer

RIKEN - Retinoic acid receptor-alpha-selective agonist prevents allograft rejection

Ranbaxy Pharmaceuticals Inc. - Panixine Disperdose launched for treatment of skin infections

Recom Managed Systems, Inc. - Life sciences company announces new member of medical advisory board

RegeneRx Biopharmaceuticals, Inc. - Biopharmaceutical company adds medical and scientific advisory board member

Regina Elena National Cancer Institute, Rome - Carboplatin and weekly paclitaxel safely manage advanced lung cancer

Roche Pharmaceuticals - Long-term relief from arthritis could evolve from B-cell targeted treatments

Royal Melbourne Hospital - Re-entrant tachycardia reported in patient with normal ventricular function

STAAR Surgical Company - Ophthalmic product manufacturer to sell 2.0 million shares of common stock

Saint Antoine Hospital - GemOx more effective than gemcitabine alone in pancreatic cancer study

Science Institute Casa Sollievo Sofferenza - Female AI patients with hypercortisolism are at risk for low spinal BMD

St. Bartholomew's Hospital - Early therapy start improves exacerbation outcome in COPD

St. George Hospital, Syndey - Questionnaire proves valuable as an outcome measure in USI patients

Stanford University - Research shows hormonal regulation of the immune response

State University of New York - Treatment of insulin resistance in diabetes reviewed

Stony Brook University - MPI classification stability is questionable

Substance Abuse - Sober.com releases Sobersystems to reduce substance abuse relapse

Sunnybrook & Women's College, Toronto - Versican isoform induces neuronal differentiation and promotes neurite outgrowth

Synovis Life Technologies, Inc. - Medical device company expresses sympathy on death of board member

Synteract, Inc. - Successful upgrade of ORACLE Adverse Event Reporting System announced

Taipei Veterans General Hospital - 3D technology pinpoints origins of irregular heart beats

Tapestry Pharmaceuticals, Inc. - Tapestry data highlights potential of NBT-287 in paclitaxel-resistant tumors

Technical University of Munich - Ascorbic acid makes cancer cells insensitive to chemotherapy

Teva Pharmaceutical Industries Ltd. - Pharmaceutical company receives FDA approval of ciprofloxacin tablets

The Immune Response Corporation - New data on Remune suggests HIV-1 specific immune responses

Therion Biologics Corporation - Vaccine shows promise in advanced pancreatic cancer, data shows

Three Rivers Pharmaceuticals, LLC - Generic drug manufacturing company announces dismissal of ICN appeal

Tufts University - Stromal tissue is the key target of mammary gland carcinogens

U.S. Centers for Disease Control and Prevention - Ad campaigns against drunk driving may be effective

U.S. Centers for Disease Control and Prevention - CDC reports latest data on suicide behaviors, risk factors, prevention

U.S. Centers for Disease Control and Prevention - States must maintain or improve antismoking programs for further progress

U.S. National Cancer Institute - U.S. perspective on toxicology approaches for oncology drugs reviewed

U.S. National Institutes of Health -  Brugia malayi immune evasion characterized

U.S. National Institutes of Health - Alcohol abuse up, but alcoholism down

U.S. National Institutes of Health - Interleukin 22 is a liver cell survival factor in murine liver injury models

Ullevaal University Hospital - VALUE study concludes angiotensin-receptor blockers can reduce blood pressure

Uniformed Svcs Univ of the Health Sci., Bethesda -  Shigella flexneri mutant shows no attenuation of virulence

Univ. of California, Berkeley - Hepatitis delta virus ribozymes are controlled by a conformational switch

Univ. of California, Los Angeles - Carrier-added tracers highlight bone lesions during bone scans

Univ. of California, Los Angeles - PCOS more prevalent in Mexican-American women

Univ. of California, San Francisco - Folding of prion protein investigated

Universidad Autonoma de Madrid - Mobility of proteins restricted in polar regions of E. coli

Universite Paul Sabatier - Fission yeast strain expressing human CDC25A phosphatase developed

University Clinic, Essen - Mesohepatectomy is an alternate option to extended hepatectomy for liver tumors

University Hospital of Essen - Dopexamine modulates cellular immune functions during systemic inflammation

University of Aberdeen - Cancer care takes a toll on rural patients in Scotland

University of Alberta - Predictive factors for osteoporosis identified in patients Crohn disease

University of Berlin - Dacarbazine induces phototoxic dermatitis in malignant melanoma patients

University of Birmingham - Different promoter organizations produce different outcomes in bacteria

University of British Columbia - Monocyte recruitment to lungs characterized in pneumococcal pneumonia

University of California, San Francisco - Aortic smooth muscle cell expression of PKG-1 characterized

University of Chieti - Antioxidants decrease in girls who gain weight during valproate therapy

University of Cologne - SV40 DNA sequences are absent in primary central nervous system lymphomas

University of Colorado, Denver - Stem cell research leads to progress in engineering pancreatic islets

University of Connecticut - Kaposi sarcoma is a model for cancer immunotherapy

University of Connecticut - N-acetyl-cysteine promotes antiangiogenesis in orthotopic breast cancer

University of Connecticut - Tiotropium is anticholinergic for once-daily treatment of COPD

University of Dusseldorf - IDO degraded by the proteasome and NO has an effect on IDO protein stability

University of Edinburgh - Inadequate vaccines can help breed more vicious malaria strains

University of Edinburgh - Scottish study of deaths in drug injectors shows early help is critical

University of Essex - Factors affecting efficiency of immunoporation cell transfection identified

University of Florence - Italian-language questionnaire to detect dysfunction due to pain shows promise

University of Freiburg - Low intracortical inhibition shown by transcranial magnetic stimulation

University of Helsinki - IUD versus oral contraception study reveals equal acceptability rates

University of Iowa - Dysferlin involved in plasma membrane repair in muscular dystrophy

University of Miami - Genetics of type 1 diabetes reviewed

University of Michigan - Polarization mapping improves spectral analysis

University of Oregon - Proteins indicate link between G1 progression and mitotic exit

University of Ottawa - apoA-II regulates HDL stability and affects hepatic lipase association

University of Padua - Human T cell leukemia virus type 1 p13II negatively regulates cell growth

University of Saarland - Lipid optimization augments solid lipid nanoparticle-mediated gene transfer

University of Sao Paulo - Dipyridamole makes cisplatin more toxic to human larynx cancer cells

University of Sao Paulo - Immunity and immunosuppression in visceral leishmaniasis reviewed

University of Sao Paulo - No adverse lipid effects found in women 35+ using triphasic combined OCs

University of Sheffield - Age at diagnosis reflects disease stage and subsequent quality of care

University of Stellenbosch - Cyclosporine has limited long-term benefits in developing areas

University of Texas Southwestern - Patients with PD and high homocysteine levels may be more likely to be depressed

University of Tokyo - Microfluidic device developed for gas-liquid-solid hydrogenation reactions

University of Tubingen - Cloned transgenic animals produce high levels of antitumor bispecific antibody

University of Utrecht - Bone tissue engineering is feasible in critical sized defects

University of Virginia - Normalizing hemoglobin aids hemodialysis patients

University of Washington - Octagam is efficacious for treating primary immunodeficiency diseases

Walter & Eliza Hall Institute of Medical Research - Negative selection of semimature thymocytes characterized

Washington University - Diabetes and heart disease risk unchanged after liposuction

West Nile Virus - Bird in Knox County, Tennessee, confirmed to have West Nile virus

World Health Organization - Study highlights burden of environment on child health in Europe

Yale University - MEKK4 helps mediate STAT4-independent IFN-gamma production

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