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Pharma Investments, Ventures and Law Weekly

Susan Hasty, Publisher

Table of Contents . . . July 18th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Pharma Investments, Ventures and Law Weekly | Other Publications

Advanced Medical Optics, Inc. - Ophthalmic surgical device maker reports preliminary 2005 guidance

BioLineRx - Israeli pharmaceutical firm completes management team

Biophan Technologies, Inc. - Financing option to be discussed at meeting by device firm

Business & Finance - I-trax awarded first health system contract for population health management

Business & Finance - Walgreens purchases Osco patient prescription records

Calypte Biomedical Corporation - Device maker files registration statement for sale of stock

Cellular Genomics, Inc. - Genomics company raises $34.9 million

ChemoCentryx, Inc. - Pharmaceutical company raises $33M in private financing

Chiron Corporation - Biotech company announces proposed $350M offering

Cougar Biotechnology, Inc. - Rights licensed for Emory University's noscapine patent portfolio

Cytokinetics, Inc. - Oncology company reports 119% increase in revenue

Diomed Holdings, Inc. - Medical device firm completes reverse split

Diversa Corporation - Genomics company announces updated financial guidance

Finance - $25M donation to endow UCLA's Neuropsychiatric Institute

Gene-IT - Bioinformatics company launches GenomeQuestLive!

Abiomed, Inc. - Cardiovascular device maker adds three to management team

Acacia Research Corporation - Marketing deal signed with Axon Instruments for microarray platform

Acceleron Pharma - Glenn Batchelder named CEO at pharmaceutical firm

Adelaide University - Methyltransferase coordinates ecdysone-mediated apoptosis in Drosophila

Advanced Magnetics, Inc. - Multicenter phase III hemodialysis study of ferumoxytol initiated

Alara Incorporated - Device manufacturer achieves new international quality certification

Alaris Medical Systems, Inc. - Wireless connectivity introduced for IV medication delivery system

Alberta Children's Hospital - Can dogs anticipate seizures in children with epilepsy?

American Bio Medica Corporation - Diagnostics company elects new board member

Aphton Corporation - Company selects Insegia as trade name for cancer drug G17DT

AstraZeneca - Consumer advocacy group calls for removal of Crestor

Autonomous University of Madrid - HDAC6 deacetylase links tubulin cytoskeleton with immune synapse

Axon Instruments, Inc. - Single-cell electroporator released

Beth Israel Deaconess Medical Center - Epoetin alfa might minimize ribavirin-related blood disorders

BioSante Pharmaceuticals, Inc. - Positive results reported in study of long-acting injectable insulin

Bioniche Life Sciences Inc. - Suplasyn study in osteoarthritis of the knee demonstrates reduced pain, costs

Breast Cancer - Weekly paclitaxel better than standard dosing schedule for metastatic disease

Brookhaven National Laboratory - Scientists study eating behaviors and brain responses to food presentation

Cancer Registry of Norway - Exposures to magnetic fields heighten a woman's risk for breast cancer

CancerVax Corp. - Novel cancer compound targets EGFR pathway; demonstrates positive trial results

Case Management Society of America - National epidemic costs more than 125,000 lives, $100 billion a year

Cell Therapeutics, Inc. - Trisenox, Vitamin C, melphalan combination produces 54% response rate

Cellumen - Company formed to understand cell functions

Centers for Disease Control & Prevention - Epidemiologic trends in shigellosis in U.S. reported

Centers for Disease Control & Prevention - Karenni refugees living in Thai-Burmese border camps experience trauma

Centers for Disease Control & Prevention - Pediatric perspective on West Nile virus infection presented

Central Institute of Animal Disease Control - Infectious bursal disease viral proteins 2 and 3 in vaccines quantified

Central Institute of Mental Health, Mannheim - Brain-derived neurotrophic factor reduced in receptor-deficient mice

Centre National de la Recherche Scientifique - Structure of potassium channel inhibitor from spider venom determined

Cerus Corporation - Initial results reported from analysis of phase III data for Intercept Blood System

Children's Hospital, Boston - Cutaneous immune sensitization is enhanced by antigen-independent IgE effects

Cima Labs, Inc. - Merger agreement with Cephalon approved

Clinical Trials Assistance Corp. - Clinical study patient recruiter company to acquire IT&E

Columbia Univ. College of Physicians and Surgeons - Topical delivery of sRAGE enhances wound healing in diabetic mice

Columbia University - Procedure appears to boost motor skills in patients with PD

Cutting Edge Information - Biogenerics set to command more than $12 billion

DOR BioPharma, Inc. - Alliance to advance development of botulinum toxin vaccines

Dana Farber Cancer Institute - Novel DHFR inhibitors active against P. carinii, T. gondii, and M. avium

Debiopharm, SA - Labopharm inks first agreement of polymeric nanodelivery systems technology

Decision Resources, Inc. - Atypical antipsychotics will drive the schizophrenia drug market

DelSite Biotechnologies, Inc. - Development of GelSite drug delivery technology reported

Diagnostic Products Corp. - Immulite 2500 SMS immunoassay system now available

Digirad Corp. - Mobile gamma camera launched

Drug Dependency - Survey reveals which professionals most affected by opiate dependency

Duke University - Xenobiotic SCFAs boost cellular sensitivity to nuclear hormone receptor ligands

Dyax Corp. - Phase II trial to begin for treatment of all forms of hereditary angioedema

EDAP TMS S.A. - Ultrasound treatment offers unique option for radiotherapy failures

Eating Disorders - Report says actress Mary-Kate Olsen being treated for eating disorder

Eli Lilly and Co. - New obesity research highlighted at ENDO 2004

Eli Lilly and Company - Adequate treatment isn't enough for most depressed patients

Emory University - Researchers make promiscuous animals monogamous by manipulating genes

Energex Systems, Inc. - FDA approves study to evaluate non-pharmacological treatment for hepatitis C

Erasmus Medical Center - Pre-B cell receptor checkpoint function reviewed

Erasmus Medical Center - Proteomic analysis of exosomes secreted by mesothelioma cells reported

Express Scripts, Inc. - More than half of COX-2 therapy study patients also take aspirin, study shows

Facilities - eRXSYS, Inc., opens pharmacy in Riverside, California

Free University of Berlin - Coronary artery disease may be an inflammatory disorder

GlaxoSmithKline - Nuclear receptor regulates thyroid hormone metabolism while dieting

H.D. Smith Wholesale Drug Co. - First drug wholesaler to implement Matrics' EPC RFID System

Hiroshima University - Serum sFas/sFasL levels have prognostic value in bile duct cancer patients

Hollis-Eden Pharmaceuticals, Inc. - Jessie Groothuis, MD, named VP, clinical affairs, of San Diego, firm

IMV Medical Information Division, Inc. - Study: Echo labs broaden clinical applications, reach of echo studies

InSite Vision, Inc. - Ophthalmics company completes $16.5 million private placement

Inha University - Delayed genomic responses to murine brain ischemia characterized

Integic Corp. - Collaboration develops end-to-end clinical trials management system

John Innes Center Plant Science Research - Novel gene (VanK) required for vancomycin resistance

Johns Hopkins University - C/EBP-beta, C/EBP-alpha, PPAR-gamma act in sequence during adipogenesis

Johns Hopkins University - PET-CT detection of abdominal recurrence of ovarian cancer needs more study

Johns Hopkins University Hospital - Hepatoma-derived growth factor is a potent regulator of endothelial cells

Kaiser Permanente - Study results published on effects of inhaled, oral steroids in pregnant women

Kanazawa University - Skin eruptions signal vascular complications after bone marrow transplants

Karl-Franzens-University of Graz - Effect of endothelin antagonism on ventricular hypertrophy determined

Karolinska University Hospital - Chromosomal aberrations may occur over time in stem cell lines

Kawatana National Hospital - Thymic cells act as myasthenogenic antigen and present antigen

Keryx Biopharmaceuticals, Inc. - Investigators report encouraging results from phase I trial of KRX-0401

Kimberly-Clark Corp. - One in three American adults lives with loss of bladder control

Kitasato University - Ampicillin-resistant Haemophilus influenzae type b increasing

Kosan Biosciences - Company presents favorable results of third phase I KOS-862 trial

Kumamoto University - Electroporation augments neuronal nitric oxide synthase transfer to the bladder

Kyushu University - Periodontal pockets increase the risk for electrocardiographic abnormalities

Kyushu University, Oita - MTI-MMP plays critical role in esophageal squamous cell carcinoma progression

Ligand Pharmaceuticals, Inc. - Drug tested at OHSU prevents MS-like disease in animals

Ludwig Institute for Cancer Research - Phosphoinositide 3-kinases mediate cell signaling

Lund University - Stability and conformational change of complement inhibitors determined

Lund University, Malmo - Plasma inflammatory biomarker levels increased in active Crohn disease

M.D. Anderson Cancer Center - Gene therapy and chemotherapeutic agents help tumors overcome TRAIL resistance

Massachusetts General Hospital - Leiomyosarcoma of somatic soft tissue described

Mayo Clinic - IL-4 induced by measles virus measured by IL-4 receptor-blocking ELISA

Mayo Clinic Scottsdale - Intravenous morphine improves MR cholangiopancreatography image quality

MedAssets - UNC HCS inks supply chain agreement

Medical Research Council, London - Quality of life is often overlooked in small cell lung cancer randomized trials

Merck & Co., Inc. - 49% of surveyed migraine sufferers delay or avoid taking medication

Molecular Insight Pharmaceuticals - MDS Nordion to manufacture BMIPP

Mylan Laboratories, Inc. - Bertek Pharmaceuticals to change name

NanoBio - Nano-emulsion company adds Jay Birnbaum, PhD, to science advisory board

National Center Cell Science, Maharashtra -  Leishmania modulates CD40-engaged, reciprocally functioning signaling modules

NeoPharm, Inc. - NeoPhectin maker appoints new president/CEO and a new chairman

Nerima Hikarigaoka Nihon University Hospital - GRAP gene may be involved in Sjogren syndrome pathogenesis

New York Medical College - Researcher issues caution on live virus vaccines

Newcastle General Hospital, Tyne & Wear - Microvascular changes arise in the major organ systems of sleep apnea models

Non-Invasive Monitoring Systems, Inc. - Imaging company achieves break-even third-quarter financial results

Obesity and Lung Function - Obese women in study improve lung function after weight loss

OncoGenex Technologies, Inc. - Companies report "compelling data" from phase I prostate cancer study

Pfizer Inc. - In vitro resistance results may not indicate clinical outcomes

Pharmaceutical Research - U.S. Agency to tighten rules on scientists' work with drug industry

Possis Medical, Inc. - CEO of medical device company receives award from Ernst & Young

Premier, Inc. - Premier hires new vice president for Pharmacy Services

Purdue University - Targeting of agents to macrophages in rheumatoid arthritis reviewed

Queen Mary's School of Medicine & Dentistry - New forms and new inhibitors of cyclooxygenases reviewed

Radcliffe Infirmary, Oxford - QOL after treatment for squamous cell carcinoma of the base of tongue is good

Regional Center for Science & Technology Research, - DNA damaged by paclitaxel is repaired over time

Rigel Pharmaceuticals, Inc. - Patents cover methods for identifying, measuring E3 ubiquitin ligase activity

Roche Diagnostics -  Bio-IT World awards technology for identification of insulin sensitivity

Rose Biomedical - NIH-funded study identifies new tool to help individuals with COPD

Royal Free & Univ. College Medical School, London - Hormonal effects on rat urinary bladder may shed light on treatment for women

San Francisco General Hospital - CSF quinolinic acid levels are determined by local HIV infection

Schering-Plough Corporation - Pharmaceutical company announces senior vice president, global medical affairs

Scripps Research Institute - Protein can reverse DNA damage

Scripps Research Institute - Researchers treat cocaine addiction with viruses

Semmelweis University of Medicine - Parasympathetic cardiac nerve stimulation resolves atrial fibrillation

Sheffield Occup. & Environmental Lung Injury Ctr. - Immunologic response to inhaled endotoxins clarified

Society of Nuclear Medicine - Combined PET/CT scanner significantly better than CT and PET in staging tumors

Somanetics Corporation - Medical device manufacturer reports record net revenues in second quarter

Somaxon Pharmaceuticals Inc. - Pharmaceuticals company closes $23 million financing

Southwest Found. for Biomedical Res., San Antonio - Hepadnavirus L proteins contain separate domains that impact infectivity

Spectranetics Corporation - Clinical trial to study excimer laser catheters in heart attack patients

Stanford University - Stochastic model reveals why signaling proteins need to be colocalized

Tata Memorial Hospital, Bombay - New approach to head and neck reconstruction surgery described

Temple University - Angiocidin mediates the antitumor activity of thrombospondin-1

Temple University - Synthetic retinoids induce apoptosis in ovarian carcinoma cells

Texas Children's Cancer Center - Ethanol superior to formalin for mRNA preservation in tissue

Townsend Associates, Pittsburgh - Flow-type spirometer errors that elevate test results described

Trudeau Institute - Regulatory CD38 activity clarified

U.K. Association of Cancer Registries - Age gap brings cancer inequality

U.S. Centers for Disease Control & Prevention - Preventing spread of SARS in healthcare facilities outlined

U.S. Food & Drug Administration - Independence of statistician who analyses unblinded data discussed

U.S. National Cancer Institute - A new HPLC assay quantifies the angiogenesis inhibitor SU5416 in plasma

U.S. Naval Medical Research Center - Genetic immunization effective against anthrax

U.S. Naval Medical Research Center - Safety and antibody responses sequential malaria vaccines reported

US Oncology - Abraxane active in taxane-refractory breast cancer patients

USC University Hospital - New technology offers ICD, pacemaker patients monitoring via the Internet

Univ. of California, Davis - Prolonged tenofovir administration results in adverse effects on kidney and bone

Univ. of California, Irvine - Spatial variations reported in properties of healthy breast tissue

Univ. of Texas SW Medical Center - BOLD contrast discerns vascular disruptions after tumor therapy

University Clinic, Munich - Antihypertensives are useful in preventing cerebrovascular events

University Hospital Maastricht - Antiangiogenic treatment could prove to be new treatment approach

University Hospital, Linkoping - Cathepsin D decrease in breast cancer mediated by IGF-II receptor

University of Aachen - High leptin levels predict renewed weight loss in anorexic patients

University of Amsterdam - Lethal damage repair does not depend on TP53 in glioblastoma cells

University of Antwerp - Molecular diagnostic tools aim to identify healthy persons with prion disorders

University of Birmingham - Retinoid-related molecule potently induces apoptosis in prostate cancer cells

University of Birmingham - Study casts doubt over effectiveness of cholinesterase inhibitors for treatment

University of British Columbia - DP-RAPD methodology infers genetic similarity among closely related viruses

University of California, San Francisco - Heightened BAFF dependence reduces survival of autoantigen-engaged B cells

University of Cologne - Utility of auditory brainstem implants reviewed

University of Colorado - VP1N-terminal region not a major determinant of human cell permissiveness

University of Hawaii Manoa - The kava alkaloid pipermethystine produces death in liver cells

University of Mainz - Neurotrophin-3 regulates mast cell functions in neonatal mouse skin

University of Massachusetts - Differentiation-dependent cellular cofactors of RT rate limiting in monocytes

University of Michigan - Transient hallucinogen self-administration indicate weak and/or aversive effects

University of Naples Federico II - Dopamine2 receptor expressed in 80% of corticotroph pituitary tumors

University of North Texas - ApoE-knockout mouse elucidates oxidation influencing Alzheimer disease

University of Pennsylvania - Mutations in Env coreceptor binding site reduces CCR5 binding to various extents

University of Pennsylvania - The 1-cys peroxiredoxin gene protects murine lungs against hyperoxic injury

University of Pittsburgh - Female otolaryngologists earn less than their male counterparts

University of Pittsburgh - Raloxifene doesn't appear to mimic estrogen's cognitive effects in rat study

University of Strasbourg 1 - Interaction between NCp7 and cTAR is characterized

University of Tennessee - Liposomal encapsulation of nisin enhances anti-Listeria efficacy

University of Toronto - Lung disorder now has become women's issue

University of Tsukuba - Overexpressed p53 is involved in the pathogenesis of fatty liver disease

University of Tubingen - Soluble Fas and its ligand associate with hepatitis B virus-related progression

University of Tuebingen, Germany - FMISO-PET can predict tumor recurrence

University of Utrecht - Reduced GRK2 in T cells potentiates chemotaxis and signaling in response to CCL4

University of Washington - Virtual reality significantly reduces pain-related brain activity

Valeant Pharmaceuticals - Second phase III study of Viramidine in hepatitis C commences

VasGene Therapeutics, Inc. - Veglin trial shows potential in fighting angiogenesis and tumor progression

Washington University - Chinese herbs exhibit antitumor effects in mouse lung tumor models

Washington University - CpG DNA redirects class-switching towards Th1-like Ig isotype production

Washington University School of Medicine - Newly grown kidneys can sustain life in rats

Wayne State University - Central nervous system complications in diabetes reviewed

Yale University - Arrhythmias may hold key to gender differences in sudden death

Yonsei University - JNK activation may play role in pathogenesis

Yonsei University - TLR3 isoform cloned and characterized

dj Orthopedics, Inc. - Medical device company completes redemption of senior subordinated notes

eResearchTechnology, Inc. - $1.7M awarded to study cardiac safety monitoring

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