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University of Oxford

Progress in DNA-based immunization strategies for malaria reported

Published in Pharma Investments, Ventures and Law Weekly, July 25th, 2004

Researchers report progress in DNA-based heterologous prime-boost immunization strategies for malaria.

According to a study from England, "An effective vaccine against malaria is urgently required to relieve the immense human suffering and mortality caused by this parasite. A successful subunit vaccine against the liver stage of malaria will require the induction of high levels of protective T cells. Despite success in small animal models, DNA vaccines fail to induce strong cellular immune responses in humans. However, DNA vaccines can induce a T-cell response that can be strongly boosted by recombinant viral vectors."

"We have evaluated this...

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